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Consanguinity and Multiple Sclerosis Susceptibility: A Case Control Study Publisher Pubmed



Maghzi H1 ; Shaygannejad V1 ; Minagar A2 ; Hassanzadeh A3 ; Maghzi AH4
Authors
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Authors Affiliations
  1. 1. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, United States
  3. 3. Department of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Source: Multiple Sclerosis and Related Disorders Published:2016


Abstract

Background Several lines of evidence point towards the importance of genetic risk factors in the susceptibility to multiple sclerosis (MS). We aimed to compare the rates of consanguineous marriages between first cousins among parents of MS patients and a healthy unrelated control group. Method This study is a cross-sectional hospital registry based study, which was performed by analyzing the clinical records of patients registered with the Kashani hospital database, and also a control group of randomly selected healthy individuals. Result MS patients were significantly less an offspring of a consanguineous union than the control group (MS patients=26.1%, vs Control=32.7%, p=0.03; OR=0.730 95%CI: 0.55–0.97) Conclusion Offspring of consanguineous unions seems to have a lower risk of MS compared to offspring of unrelated parents. This may have implications for inheritance mode of protective alleles in MS. © 2016 Elsevier B.V.
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