Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Magnesium Supplementation on Anthropometric Indices: A Systematic Review and Dose-Response Meta-Analysis of Clinical Trials Publisher Pubmed



Rafiee M1 ; Ghavami A1 ; Rashidian A2 ; Hadi A3 ; Askari G4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Industrial Engineering, Sharif University of Technology, Tehran, Iran
  3. 3. Halal Research Center of Iri, Food and Drug Administration, Tehran, Iran
  4. 4. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: British Journal of Nutrition Published:2021


Abstract

Abstract The aim of this study was to determine the effects of Mg supplementation on anthropometric indices consisting of body weight, waist circumference (WC), BMI and body fat percentage. In this systematic review and dose-response meta-analysis, we searched PubMed, Cochrane Library, Scopus, Web of Science and Google Scholar from databases inception up to February 2020 for relevant randomised controlled trials. Quality of evidence was evaluated using the Cochrane Collaboration Tool. All the outcomes of this meta-analysis were pooled using the random effect model. Analysis of dose-response for Mg dosage was carried out using a fractional polynomial model. The systematic review and meta-analysis include twenty-eight randomised clinical trials, comprising 2013 participants. There were no significant changes in anthropometric indices after Mg supplementation in the overall analysis. However, subgroup analysis revealed that Mg supplementation decreases WC in subjects with BMI > 30 kg/m (obese) (twelve trials, n 997 participants; weighted mean difference = -2·09 cm, 95 % CI -4·12, -0·07, P = 0·040; I = 0 %). Dose-response analysis revealed a non-significant non-linear effect of supplementation dosage on anthropometric indices. The results suggest that Mg supplementation is associated with lower WC only in obese subjects. However, more high-quality studies are needed to clarify the nature of this association. ©
Related Docs
View other Related Docs
1. The Effects of Magnesium Supplementation on Blood Pressure and Obesity Measure Among Type 2 Diabetes Patient: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Biological Trace Element Research (2021)
2. Alpha-Lipoic Acid Supplement in Obesity Treatment: A Systematic Review and Meta-Analysis of Clinical Trials, Clinical Nutrition (2018)
3. The Effect of Oral Magnesium Supplementation on Inflammatory Biomarkers in Adults: A Comprehensive Systematic Review and Dose–Response Meta-Analysis of Randomized Clinical Trials, Biological Trace Element Research (2022)
4. Possible Anti-Obesity Effects of Phytosterols and Phytostanols Supplementation in Humans: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2019)
5. The Effects of Oral Magnesium Supplementation on Glycaemic Control in Patients With Type 2 Diabetes: A Systematic Review and Dose-Response Meta-Analysis of Controlled Clinical Trials, British Journal of Nutrition (2022)
6. The Effects of Magnesium Supplementation on Lipid Profile Among Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Biological Trace Element Research (2021)
7. Magnesium Status and the Metabolic Syndrome: A Systematic Review and Meta-Analysis, Nutrition (2016)
8. Clinical and Metabolic Responses to Magnesium Supplementation in Women With Polycystic Ovary Syndrome, Biological Trace Element Research (2020)
Experts (# of related papers)
View all Related Experts
Abed Ghavami (20)
Gholamreza Askari (18)
Other Related Docs
9. Effect of Oral Magnesium Supplement on Cardiometabolic Markers in People With Prediabetes: A Double Blind Randomized Controlled Clinical Trial, Scientific Reports (2022)
10. Associations Between Serum Magnesium Concentrations and Polycystic Ovary Syndrome Status: A Systematic Review and Meta-Analysis, Biological Trace Element Research (2021)
11. The Effects of Royal Jelly Supplementation on Anthropometric Indices: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Frontiers in Nutrition (2023)
12. The Effects of Green Tea Extract Supplementation on Body Composition, Obesity-Related Hormones and Oxidative Stress Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomised Controlled Trials, British Journal of Nutrition (2024)
13. Oral Magnesium Supplementation Improved Lipid Profile But Increased Insulin Resistance in Patients With Diabetic Nephropathy: A Double-Blind Randomized Controlled Clinical Trial, Biological Trace Element Research (2020)
14. Beneficial Effects of L-Carnitine Supplementation for Weight Management in Overweight and Obese Adults: An Updated Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2020)
15. Magnesium Supplementation Affects Metabolic Status and Pregnancy Outcomes in Gestational Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, American Journal of Clinical Nutrition (2015)
16. The Effects of Nigella Sativa on Anthropometric Indices: A Grade-Assessed Systematic Review and Dose–Response Meta-Analysis of Controlled Trials, Journal of Functional Foods (2023)
17. The Effects of Curcumin Supplementation on Body Weight, Body Mass Index and Waist Circumference: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Critical Reviews in Food Science and Nutrition (2020)
18. Effects of Spirulina Supplementation on Obesity: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Medicine (2019)
19. Total, Dietary, and Supplemental Magnesium Intakes and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Advances in Nutrition (2021)
20. Effect of Sumac Powder Supplementation on Anthropometric Indices: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, Journal of Herbal Medicine (2023)
21. The Effect of Green Coffee Extract Supplementation on Anthropometric Measures in Adults: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Medicine (2020)
22. Efficacy of Synbiotic Supplementation in Obesity Treatment: A Systematic Review and Meta-Analysis of Clinical Trials, Critical Reviews in Food Science and Nutrition (2020)
23. Association of Serum Concentrations of Magnesium and Some Trace Elements With Cardiometabolic Risk Factors and Liver Enzymes in Adolescents: The Caspian-Iii Study, Biological Trace Element Research (2015)
24. Cinnamon Supplementation Positively Affects Obesity: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Clinical Nutrition (2020)
25. Effects of Pro-/Synbiotic Supplementation on Anthropometric and Metabolic Indices in Overweight or Obese Children and Adolescents: A Systematic Review and Meta-Analysis, Complementary Therapies in Medicine (2019)
26. A Systematic Review and Meta-Analysis of Probiotic Consumption and Metabolic Status of Athletes, International Journal of Food Properties (2020)
27. The Effects of Supplementation With Conjugated Linoleic Acid on Anthropometric Indices and Body Composition in Overweight and Obese Subjects: A Systematic Review and Meta-Analysis, Critical Reviews in Food Science and Nutrition (2019)
28. Dose-Dependent Effect of Megestrol Acetate Supplementation in Cancer Patients With Anorexia–Cachexia Syndrome: A Meta-Analysis, Journal of Cachexia, Sarcopenia and Muscle (2024)
29. Impact of Flaxseed Supplementation on Plasma Lipoprotein(A) Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2020)
30. Does Cocoa/Dark Chocolate Supplementation Have Favorable Effect on Body Weight, Body Mass Index and Waist Circumference? a Systematic Review, Meta-Analysis and Dose-Response of Randomized Clinical Trials, Critical Reviews in Food Science and Nutrition (2019)
31. The Association Between Maternal Exposure to Organophosphate Pesticides and Neonatal Anthropometric Measures: A Systematic Review and Meta-Analysis, Journal of Research in Medical Sciences (2020)
32. The Effectiveness of Bright Light Exposure in Shift-Worker Nurses: A Systematic Review and Meta-Analysis, Sleep Science (2020)
33. The Effects of Magnesium and Vitamin E Co-Supplementation on Some Cardiovascular Risk Factors: A Meta-Analysis, Clinical Nutrition ESPEN (2021)
34. Impact of Melatonin Supplementation on Glycemic Parameters in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis, Current Pharmaceutical Design (2025)
35. The Effects of Supplementation With Cynara Scolymus L. on Anthropometric Indices: А Systematic Review and Dose-Response Meta-Analysis of Clinical Trials, Complementary Therapies in Medicine (2021)
36. The Effect of Curcumin Supplemsentation on Anthropometric Indices in Overweight and Obese Individuals: A Systematic Review of Randomized Controlled Trials, Advances in Experimental Medicine and Biology (2021)
37. The Effects of Supplementation With L-Arginine on Anthropometric Indices and Body Composition in Overweight or Obese Subjects: A Systematic Review and Meta-Analysis, Journal of Functional Foods (2020)
38. Efficacy of L-Carnitine Supplementation for Management of Blood Lipids: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2019)
39. Effect of Omega-3 Fatty Acids Supplementation on Anthropometric Indices in Children and Adolescents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
40. The Therapeutic Effects of Magnesium in Insulin Secretion and Insulin Resistance, Advanced Biomedical Research (2022)
41. Garlic Supplementation Reduces Circulating C-Reactive Protein, Tumor Necrosis Factor, and Interleukin-6 in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Nutrition (2019)
42. The Effects of Ginseng Supplementation on Anthropometric Indices and Body Composition: A Systematic Review and Meta-Analysis, Journal of Herbal Medicine (2020)
43. The Effects of Silymarin Consumption on Inflammation and Oxidative Stress in Adults: A Systematic Review and Meta-Analysis, Inflammopharmacology (2024)
44. Dietary Magnesium Intake, Bone Mineral Density and Risk of Fracture: A Systematic Review and Meta-Analysis, Osteoporosis International (2016)
45. The Effect of Vitamin D Supplementation on Body Composition in Nursing Mothers With Overweight or Obesity: A Randomized Double-Blind Placebo-Controlled Clinical Trial, BMC Nutrition (2023)
46. What About My Weight? Insufficient Weight Loss or Weight Regain After Bariatric Metabolic Surgery, International Journal of Endocrinology and Metabolism (2023)
47. The Effect of Soy Products on Circulating Adiponectin and Leptin Concentration in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, International Journal of Clinical Practice (2021)
48. Validation Study of Self-Reported Anthropometric Indices Among the Staff of the Isfahan University of Medical Sciences, Isfahan, Iran, Journal of Isfahan Medical School (2015)
49. The Association Between Vitamin C Dietary Intake and Its Serum Levels With Anthropometric Indices: A Systematic Review and Meta-Analysis, Complementary Therapies in Clinical Practice (2023)
50. Efficacy of Socket-Shield Technique on Tissue Stability of Immediate Implant Placement: A Systematic Review With Meta-Analysis and Trial Sequential Analysis, Dental Hypotheses (2022)