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Evaluation of the Anti-Tuberculosis and Cytotoxic Potential of the Seaweed Padina Australis



Vaseghi G1 ; Zakeri N2 ; Mazloumfard F2 ; Dana N3 ; Yegdaneh A2
Authors
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Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical sciences, Isfahan, Iran
  2. 2. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, and Isfahan Pharmaceutical Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Applied Physiology Research Center, Cardiovascular research institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Pharmaceutical Sciences Published:2020

Abstract

Marine seaweeds synthesize different types of compounds with various biological activities, including anti-tuberculosis and anticancer effects. The aim of this study was to evaluate anti tuberculosis of Padina australis and cytotoxicity of different fractions of this seaweed. Padinaaustralis was collected from Persian Gulf, identified and extracted by maceration with methanol-ethyl acetate. The extract was evaporated and partitioned by Kupchan method to yield Hexane, dichloromethane, Butanol and water partitions. The anti-tuberculosis activity of the crude extract and cytotoxicity of fractions were investigated using GFPMA and MTT methods. The cell survivals of HeLa cell were decreased by increasing the concentration of extracts. The IC50 value of hexane, dichloromethane, butanol and water partitions were 2.0, 20, 19.7, and 182.7μg/ml, respectively. The crude extract was not active against tuberculosis. This study reveals that different partitions of Padina australis have cytotoxic activity against cancer cell lines. © 2020, Iranian Association of Pharmaceutical Scientists. All rights reserved.
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