Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Cytotoxic Effects of the Extracts of Iranian Taxus Baccata and Cupressus Horizentalis on Cancer Cells Publisher



Sadeghialiabadi H1 ; Emami SA2 ; Saeidi M1 ; Jafarian A3
Authors

Source: Iranian Journal of Pharmaceutical Research Published:2003


Abstract

It has been reported that several conifers possess cytotoxic activities on some human tumor cell lines. Taxol as a natural cytotoxic compound has been extracted from this family. In a program to screen the cytotoxic effects of natural resources, male and female branchlets, fruit or bark of two different species of Iranian conifers were collected, identified and the cytotoxic effects of their hydroalcoholic extracts on three human tumor cell lines were determined. Different concentrations of extracts were added to cultured cells and incubated for 72 h. Cell survival was evaluated using MTT assay. Extracts from bark of female Taxus baccata showed inhibitory activities against Hela cells. The extracts of the branchlets of male and female T. baccata and branchlets of Cupressus horizentalis showed inhibitory activities against MDA-MB-468 cells, whereas the extracts of branchlets of female T. baccata showed inhibitory activities against KB cells. In conclusion, extract obtained from the bark of Iranian T. baccata showed a comparable cytotoxic effect to doxorubicin against Hela cells. © 2003, Iranian Journal of Pharmaceutical Research. All rights reserved.
Related Docs
View other Related Docs
1. Cytotoxic Evaluations of Iranian Conifers on Cancer Ells, Pharmaceutical Biology (2005)
2. Evaluation of in Vitro Cytotoxic Effects of Juniperus Foetidissima and Juniperus Sabina Extracts Against a Panel of Cancer Cells, Iranian Journal of Pharmaceutical Research (2009)
3. Cytotoxic Evaluation of Different Extracts of Taxus Baccata Against Mda-Mb-468, Hela and K562 Cancer Cell Lines, Journal of Isfahan Medical School (2013)
Experts (# of related papers)
View all Related Experts
Hojjat Sadeghi-Aliabadi (7)
Abbas Jafarian (5)
Other Related Docs
4. Cytotoxic Effects of Essential Oils of Some Iranian Citrus Peels, Iranian Journal of Pharmaceutical Research (2005)
5. Cytotoxicity and Antitumor Properties of a Marine Compound, Hesa-A, on Cancer Cells, Daru (2003)
6. Evalution of Cytotoxic Effect of Some Extracts of Avicennia Marina Against Mda-Mb 231 Human Breast Cancer Cell Line, Pharmaceutical Sciences (2011)
7. Cytotoxic Effects of Pinus Eldarica Essential Oil and Extracts on Hela and Mcf-7 Cell Lines, Research in Pharmaceutical Sciences (2016)
8. Cytotoxic Effects of Different Extracts and Latex of Ficus Carica L. on Hela Cell Line, Iranian Journal of Pharmaceutical Research (2011)
9. Optimization of the Basal Medium for Improving Production and Secretion of Taxanes From Suspension Cell Culture of Taxus Baccata L, DARU, Journal of Pharmaceutical Sciences (2012)
10. The Cytotoxic and Pro-Apoptotic Effects of Various Extracts of Allium Giganteum on Mcf-7 and Hela Cell Lines, Journal of Isfahan Medical School (2021)
11. Cytotoxic Effects of Chloroform and Hydroalcoholic Extracts of Aerial Parts of Cuscuta Chinensis and Cuscuta Epithymum on Hela, Ht29 and Mda-Mb-468 Tumor Cells, Research in Pharmaceutical Sciences (2014)
12. Effect of Salicylic Acid and Silver Nitrate on Taxol Production in Taxus Baccata, Journal of Medicinal Plants (2012)
13. Cytotoxic Evaluation of Volatile Oil From Descurainia Sophia Seeds on Mcf-7 and Hela Cell Lines, Research in Pharmaceutical Sciences (2015)
14. A Comparison of Thiazolyl Blue (Mtt) Versus Sulforhodamine B (Srb) Assay in Assessment of Antiproliferative Effect of Bromelain on 4T1, Ags, and Pc3 Cancer Cell Lines, Journal of Isfahan Medical School (2017)
15. Phytochemical Analysis and Cytotoxicity Evaluation of Kelussia Odoratissima Mozaff., JAMS Journal of Acupuncture and Meridian Studies (2017)
16. Investigating the Effects of Bark Extract and Volatile Oil of Pinus Eldarica Against Cisplatin-Induced Genotoxicity on Huvecs Cell Line, Toxicology Research (2021)
17. Dihydroartemisinin Induces Apoptosis in Human Bladder Cancer Cell Lines Through Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cytochrome C Pathway, International Journal of Preventive Medicine (2017)
18. In Vitro Evaluation the Anti-Melanogenic Effects of Various Extracts of Oat Seeds, Iranian Journal of Pharmaceutical Sciences (2022)
19. Cytotoxic Sulfoquinovosyl Glycerols From the Seaweed Sargassum Angustifolium From Persian Gulf, Advanced Biomedical Research (2025)
20. Centaurea Cyanus Extracted 13-O-Acetylsolstitialin a Decrease Bax/Bcl-2 Ratio and Expression of Cyclin D1/Cdk-4 to Induce Apoptosis and Cell Cycle Arrest in Mcf-7 and Mda-Mb-231 Breast Cancer Cell Lines, Journal of Cellular Biochemistry (2019)