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Effect of Vasopressin on Electrocardiographic Changes Produced by Ischemia-Reperfusion in Rats Publisher Pubmed



Nazari A1 ; Mohamadi A1 ; Imani AR2 ; Faghihi M2 ; Tarahi MJ3 ; Moghimian M4 ; Cheraghi M5
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Authors Affiliations
  1. 1. Razi Herbal Medicines Research Center, Department of Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Physiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
  5. 5. Department of Cardiology, Lorestan University of Medical Sciences, Khoramabad, Iran

Source: Pakistan Journal of Pharmaceutical Sciences Published:2021


Abstract

The present study was conducted to identify the effect of vasopressin (AVP) on electrocardiographic changes produced by ischemia-reperfusion. Male rats were divided into seven groups (n=8-13) subjected to 30min ischemia and 120 min reperfusion. In protocol I (control group), saline was administered before ischemia. In protocol II, different doses of AVP (0.015, 0.03, 0.06 and 0.12μg/rat) were infused 10 min before ischemia. In protocol III SR49059 (1 mg/kg), was injected 20 min prior to ischemia with and without the effective dose of AVP (0.03 g/rat). Ischemia-induced arrhythmia and myocardial infarct size (IS) were measured. Different doses of vasopressin decreased IS. There were no significant differences in PR, QRS duration and ΔT/ΔST ratio between control and intervention groups in ischemia. ST elevation was significantly increased in control and AVP 0.015, 0.03, 0.06 groups during ischemia. In AVP 0.12 group there was no significant difference in ST deviation between the baseline and ischemia phase. JT interval was significantly increased in control and antagonist group during ischemia. AVP 0.12μg/rat prevented the increase of JT interval in ischemia compared to the baseline. In summary, AVP mediated preconditioning improved ST resolution, prevented prolongation of JT interval and decreased the likelihood of subsequently ventricular arrhythmia. © 2021 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.
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