Isfahan University of Medical Sciences

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Association of Tim-1 5383-5397Ins/Del and Tim-3 -1541C>T Polymorphisms With Multiple Sclerosis in Isfahan Population Publisher Pubmed



Mazrouei F1 ; Ganjalikhanihakemi M1 ; Salehi R2 ; Alesahebfosoul F1 ; Etemadifar M3 ; Pouladian M1 ; Meshkat R4 ; Nekoueian S5 ; Zarkeshesfahani H6 ; Ziyaeeghahnaviyeh M1
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Source: International Journal of Immunogenetics Published:2016


Abstract

Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in autoimmune diseases. In this study, for the first time, the association of TIM-1 5383-5397ins/del and TIM-3 -1541C>T polymorphisms with MS in an Iranian population was considered. The results of our study showed that there is no significant association between TIM-1 5383-5397ins/del and MS (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS (P = 0.009, OR = 4.08). © 2016 John Wiley & Sons Ltd.
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