Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of Tim-1 5383-5397Ins/Del and Tim-3 -1541C>T Polymorphisms With Multiple Sclerosis in Isfahan Population Publisher Pubmed



Mazrouei F1 ; Ganjalikhanihakemi M1 ; Salehi R2 ; Alesahebfosoul F1 ; Etemadifar M3 ; Pouladian M1 ; Meshkat R4 ; Nekoueian S5 ; Zarkeshesfahani H6 ; Ziyaeeghahnaviyeh M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Department of Cellular and Molecular Biology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Department of Neurosciences, Al-Zahra Hospital, Isfahan University of Medical Science, Isfahan, Iran
  4. 4. Department of Immunology, School of Medicine, Shahrekord University of Medical Science, Sharekord, Iran
  5. 5. Department of Molecular Diagnosis, Provincial Health Center, Isfahan University of Medical Science, Isfahan, Iran
  6. 6. Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran

Source: International Journal of Immunogenetics Published:2016


Abstract

Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in autoimmune diseases. In this study, for the first time, the association of TIM-1 5383-5397ins/del and TIM-3 -1541C>T polymorphisms with MS in an Iranian population was considered. The results of our study showed that there is no significant association between TIM-1 5383-5397ins/del and MS (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS (P = 0.009, OR = 4.08). © 2016 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. The Frequency of Tim-3-1541C>T Polymorphisms and Its Association With Multiple Sclerosis, Journal of Isfahan Medical School (2015)
2. Comparing the Frequency of Tim-3 Polymorphism in Multiple Sclerosis Patients With Healthy Controls, Journal of Isfahan Medical School (2015)
3. The +4259A>C Polymorphism of Tim-3 But Not -1637C>T Polymorphism of Tim-1 Is Associated With Multiple Sclerosis in Isfahan Population, Multiple Sclerosis and Related Disorders (2017)
4. High-Resolution Melting Curve Analysis of Polymorphisms Within Cd58, Cd226, Hla-G Genes and Association With Multiple Sclerosis Susceptibility in a Subset of Iranian Population: A Case–Control Study, Acta Neurologica Belgica (2020)
5. Association of Interleukin-1 Gene Cluster Polymorphisms and Haplotypes With Multiple Sclerosis in an Iranian Population, Journal of Neuroimmunology (2015)
6. Genetic Variation in Intergenic and Exonic Mirna Sequence and Risk of Multiple Sclerosis in the Isfahan Patients, Iranian Journal of Allergy, Asthma and Immunology (2018)
7. Association Analysis of T-Cell Immunoglobulin and Mucin 1 Gene 5383-5397 Insertion/Deletion Polymorphism With Asthma and Total Serum Immunoglobulin E Levels in Patients With Asthma and Controls, Journal of Isfahan Medical School (2014)
8. Producing Recombinant Hek293 T-Cells With High Expression of T-Cell Immunoglobulin and Mucin Domain-3 (Tim3) Protein, Journal of Isfahan Medical School (2015)
Experts (# of related papers)
View all Related Experts
Masoud Etemadifar (41)
Vahid Shaygannejad (17)
Other Related Docs
9. The Role of Non-Hla Single Nucleotide Polymorphisms in Multiple Sclerosis Susceptibility, Journal of Neuroimmunology (2010)
10. Risk Factor Effect of Rs1044165 and Rs3745453 As Neighboring Variants of Mir-223, Mir-24, Mir-23A and Mir-27A on the Onset of Ms Disease in Isfahan/Iran, Gene Reports (2018)
11. Association of Cd24v/V Genotype With Susceptibility and Progression of Multiple Sclerosis in Iranian Population, Iranian Journal of Biotechnology (2008)
12. Serum Level of Interleukin 36 in Patients With Multiple Sclerosis, Journal of Immunoassay and Immunochemistry (2018)
13. Cd24 Gene Allele Variation Is Not Associated With Oligoclonal Igg Bands and Igg Index of Multiple Sclerosis Patients, NeuroImmunoModulation (2012)
14. The Relationship Between the Genetic Polymorphisms of Interleukin-33 (Il-33) and Interleukin-1 Receptor-Like 1 (Il1r1) With the Levels of Interleukin-33 in Patients With Asthma and Multiple Sclerosis, Journal of Isfahan Medical School (2016)
15. Association of Aire Polymorphism and the Susceptibility to Multiple Sclerosis in Iranian Population, Avicenna Journal of Medical Biotechnology (2018)
16. Association Study Between Functional Polymorphisms of Mmp9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population, Iranian Journal of Public Health (2019)
17. Evaluation of the Frequency of Osteopontin Gene Polymorphism (Rs28357094 T>G) and Its Receptor Gene (Itga4- Rs1449263 A>G) in Multiple Sclerosis Patients in Comparison to Healthy Controls in Isfahan, Iran, Population, Journal of Isfahan Medical School (2016)
18. Male Microchimerism in Peripheral Blood From Women With Multiple Sclerosis in Isfahan Province, International Journal of Immunogenetics (2020)
19. Can Plasma Exchange Therapy Induce Regulatory T Lymphocytes in Multiple Sclerosis Patients?, Clinical and Experimental Immunology (2012)
20. Investigation of Erg Gene Expression in Iranian Patients With Multiple Sclerosis, Immunological Investigations (2018)
21. Lncrnas Associated With Multiple Sclerosis Expressed in the Th1 Cell Lineage, Journal of Cellular Physiology (2019)
22. An Investigation Into the Association Between Hla-G 14Bp Insertion/Deletion Polymorphism and Multiple Sclerosis Susceptibility, Journal of Neuroimmunology (2016)
23. The Comparative Analysis of Serum Levels of Midkine in Patients With Multiple Sclerosis and Control Group, Journal of Isfahan Medical School (2013)
24. Therapeutic Targeting of Chemokines and Chemokine Receptors in Multiple Sclerosis: Opportunities and Challenges, CNS and Neurological Disorders - Drug Targets (2018)
25. Prognostic Value of Intrathecal Igg Synthesis in Multiple Sclerosis: A Study in 54 Patients, Tehran University Medical Journal (2008)
26. Prevalence of Familial Multiple Sclerosis in Isfahan, Iran, Journal of Isfahan Medical School (2011)
27. Multiple Sclerosis: Pathophysiology, Clinical Features, Diagnosis, and Management, Neuroinflammation (2011)
28. High Prevalence of Mmp9 −1562C/T Gene Polymorphism in an Iranian Population of Neuromyelitis Optica, a Pilot Study, Gene Reports (2021)
29. The Global Prevalence of Familial Multiple Sclerosis: An Updated Systematic Review and Meta-Analysis, BMC Neurology (2021)
30. Association Between +4259 T>G and -574 G>T Polymorphisms of Tim-3 With Asthma in an Iranian Population, Iranian Journal of Allergy, Asthma and Immunology (2017)
31. Evaluation of the Expressed Mir‑129 and Mir‑549A in Patients With Multiple Sclerosis, Advanced Biomedical Research (2021)
32. Co-Occurrence of Multiple Sclerosis and Thomsen’S Myotonia: A Report of Two Cases, Functional Neurology (2014)
33. An Integrated Bioinformatics Analysis of the Potential Regulatory Effects of Mir-21 on T-Cell Related Target Genes in Multiple Sclerosis, Avicenna Journal of Medical Biotechnology (2021)
34. Elevated Serum Level of Il-4 in Neuromyelitis Optica and Multiple Sclerosis Patients, Journal of Immunoassay and Immunochemistry (2019)
35. Cytokine Gene Expression in Newly Diagnosed Multiple Sclerosis Patients, Iranian Journal of Allergy, Asthma and Immunology (2015)
36. Cytomegalovirus Seroposivity in Iranian Multiple Sclerosis: A Randomized Case-Control Study, Pakistan Journal of Medical Sciences (2012)
37. Neutralizing Antibodies in Multiple Sclerosis Patients on Weekly Intramuscular Avonex and Biosimilar Interferon Beta-1A (Cinnovex): Comparing Results of Measurements in Two Different Laboratories, Journal of Immunological Methods (2013)
38. Chlamydia Pneumoniae Seropositivity in Iranian Patients With Multiple Sclerosis: A Pilot Study; [Obecnosc Przeciwcial Przeciw Chlamydia Pneumoniae Wsrod Iranskich Chorych Na Stwardnienie Rozsiane: Badanie Pilotazowe], Neurologia i Neurochirurgia Polska (2011)
39. Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms, Journal of Neuroimmunology (2013)
40. Association of Helicobacter Pylori With Multiple Sclerosis: Protective or Risk Factor?, Current Journal of Neurology (2020)
41. Increased Serum Level of Il-37 in Patients With Multiple Sclerosis and Neuromyelitis Optica, Acta Neurologica Belgica (2015)
42. Frequency of Myasthenia Gravis in Multiple Sclerosis: Report of Five Cases From Isfahan, Iran, Neurology India (2009)
43. The Association of Multiple Sclerosis With Thyroid Disease: A Meta-Analysis, Multiple Sclerosis and Related Disorders (2023)
44. Epidemiology of Familial Multiple Sclerosis in Iran: A National Registry-Based Study, BMC Neurology (2022)
45. Multiple Sclerosis: Clinical Features, Pathophysiology, Neuroimaging and Future Therapies, Future Neurology (2009)
46. Cerebrospinal Fluid and Serum Markers of Inflammation in Patients With Multiple Sclerosis, Advances in Neuroimmune Biology (2017)
47. Interleukin-33 Plasma Levels in Patients With Relapsing-Remitting Multiple Sclerosis, Biomolecular Concepts (2017)
48. Increased Expression of Lymphocyte Activation Gene-3 by Regulatory T Cells in Multiple Sclerosis Patients With Fingolimod Treatment; [Multiple Sikleroz Hastalarinda Fingolimod Tedavisi Sonucu Duzenleyici T Hucrelerinde Lenfosit Aktivasyon Gen-3 Ekspresyonunda Artis], Turkish Journal of Immunology (2019)
49. Prevalence of Tim-3 Gene Polymorphisms in Patients With Asthma and Its Correlation With Serum Levels of Immunoglobulin-E of These Patients in Isfahan, Iran, Journal of Isfahan Medical School (2015)
50. Estimated Incidence Rate of Multiple Sclerosis and Its Relationship With Geographical Factors in Isfahan Province Between the Years 2001 and 2014, International Journal of Preventive Medicine (2018)