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The +4259A>C Polymorphism of Tim-3 But Not -1637C>T Polymorphism of Tim-1 Is Associated With Multiple Sclerosis in Isfahan Population Publisher Pubmed



Pouladian M1 ; Ganjalikhanihakemi M1 ; Alsahebfosul F1 ; Homayouni V1 ; Khosravi S2 ; Etemadifar M3 ; Mazrouei F1 ; Salehi R2
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Department of Cellular & Molecular Biology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Department of Neurosciences, Al-Zahra Hospital, Isfahan University of Medical Science, Isfahan, Iran

Source: Multiple Sclerosis and Related Disorders Published:2017


Abstract

Background Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) which initiated and mediated by autoreactive T helper1 cells directed against myelin antigens. One of T cell surface receptors is T cell immunoglobulin and mucin domain (TIM) family which its importance in immunology is recently discovered. These molecules have important immunological function by regulation of T effector cells. Methods In the present study, we analyzed the frequency of +4259 A>C polymorphism in TIM-3 and −1637C>T polymorphism in TIM-1 gene in MS patients and healthy controls using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. Results We found that the polymorphism +4259 A>C in exon 3 of the TIM-3 gene is associated with susceptibility to the MS (P = 0.029, OR (95%CI) = 1.841) but the other polymorphism, −1637T>C, in the promoter region of TIM-1 is not (p= 0.064). Conclusion Our findings suggest that +4259 A>C polymorphism in TIM-3 gene may be one of the important genetic factors associated with the MS susceptibility among Iranian populations. © 2017
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