Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women

Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women Publisher Pubmed

Khorshidi F¹ ; Hajizadeh S² ; Choobineh H³ ; Alizadeh S² ; Sharifi MJ⁴ ; Kavosh Z² ; Omidkhoda A²

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1. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2. Hematology and Blood Banking Department, Allied School of Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
3. Laboratory Science Department, Allied School of Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Gynecological Endocrinology Published:2020

Abstract

Objective: Thrombophilia is known to be associated with poor pregnancy outcomes. In this study, three thrombophilic gene polymorphisms, including EPCR (Ser219Gly), F11 (rs4253417) and F7 (323 Ins10) were investigated in an Iranian population of women in order to determine the correlation between thrombophilia and recurrent pregnancy loss (RPL). Methods: Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to evaluate the frequency of three candidate thrombophilic risk factors for recurrent pregnancy loss. The frequencies of the polymorphisms were compared between the case (144 patients with a history of at least two miscarriages) and the control (150 healthy women with no abortion) group. Results: Our results show that EPCR and FVII polymorphisms of the patient and control group have the same genotype frequency, and the difference is not statistically significant (p-value >.05). Regarding FXI polymorphism, TT genotype frequency was higher in the patient group than the control group (p-value <.05); however, CT heterozygote form was higher in the control group compared to the patient group (p-value <.05). Conclusion: In FXI polymorphism, T allele is possibly an RPL risk factor and C allele has a protective role. Thus, wild type FXI could be related to RPL, but EPCR and FVII polymorphism have no such correlation. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Khorshidi F, et al.. "Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women." Gynecological Endocrinology, vol. 36, no. 12, 2020, pp. 1082-1085.
APA	Khorshidi F, Hajizadeh S, Choobineh H, Alizadeh S, Sharifi MJ, Kavosh Z, Omidkhoda A (2020). Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women. Gynecological Endocrinology, 36(12), 1082-1085.
Chicago	Khorshidi F, Hajizadeh S, Choobineh H, Alizadeh S, Sharifi MJ, Kavosh Z, Omidkhoda A. "Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women." Gynecological Endocrinology 36, no. 12 (2020): 1082-1085.
Harvard	Khorshidi F et al. (2020) 'Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women', Gynecological Endocrinology, 36(12), pp. 1082-1085.
Vancouver	Khorshidi F, Hajizadeh S, Choobineh H, Alizadeh S, Sharifi MJ, Kavosh Z, et al.. Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women. Gynecological Endocrinology. 2020;36(12):1082-1085.
BibTex	@article{ author = {Khorshidi F and Hajizadeh S and Choobineh H and Alizadeh S and Sharifi MJ and Kavosh Z and Omidkhoda A}, title = {Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women}, journal = {Gynecological Endocrinology}, volume = {36}, number = {12}, pages = {1082-1085}, year = {2020} }
RIS	TY - JOUR AU - Khorshidi F AU - Hajizadeh S AU - Choobineh H AU - Alizadeh S AU - Sharifi MJ AU - Kavosh Z AU - Omidkhoda A TI - Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women JO - Gynecological Endocrinology VL - 36 IS - 12 SP - 1082 EP - 1085 PY - 2020 ER -

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