Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Factor Vii R353q (Rs6046), Fga A6534g (Rs6050), and Fgg C10034t (Rs2066865) Gene Polymorphisms and Risk of Recurrent Pregnancy Loss in Iranian Women Publisher



Kavosh Z1 ; Mohammadzadeh Z1 ; Alizadeh S1 ; Sharifi MJ2 ; Hajizadeh S1 ; Choobineh H3 ; Omidkhoda A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Hematology and Transfusion Science Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Immunology Department, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Laboratory Science Department, Allied School of Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

Source: Indian Journal of Hematology and Blood Transfusion Published:2024


Abstract

Recurrent pregnancy loss is a multi factorial and heterogeneous disorder defined as two or more consecutive pregnancy losses before 20 weeks’ gestation. Gene polymorphisms including factor VII R353Q (rs6046), fibrinogen alpha chain A6534G (rs6050) and fibrinogen gamma chain C10034T (rs2066865) have potential role in thrombophilia and the relation between these three polymorphisms and an increased risk of venous thrombosis have been reported. As thrombophilia is associated with a considerable proportion of pregnancy loss and the association between these gene polymorphisms and recurrent pregnancy loss remains controversial, the aim of the present study was to evaluate the relation of these polymorphisms and recurrent pregnancy loss in Iranian women. A total of 144 women with a history of two or more consecutive miscarriages as the patient group and 150 healthy women with two live births and no history of pregnancy loss as the control group were included in the study. Polymerase chain reaction and restriction fragment length polymorphism were used for genotyping. The results were validated by DNA sequencing. The SPSS, SNPStats and Finch TV were used to analyze the results. Factor VII R353Q (rs6046) gene polymorphism showed a significant difference between RPL patients and the control group according to multiple logistic regression models [codominant (OR=0.38; 95% CI=0.23-0.63, P≤0.0001), dominant (OR=0.32; 95% CI=0.20–0.52, P≤0.0001), over dominant (OR=0.46; 95% CI=0.29–0.75, P=0.0017) and log-additive (OR=0.35; 95% CI=0.23–0.53, P≤0.0001)]. Fibrinogen alpha chain A6534G (rs6050) and fibrinogen gamma chain C10034T (rs2066865) gene polymorphisms showed no correlation with recurrent pregnancy loss. Factor VII R353Q (rs6046) gene polymorphism can be considered a risk factor for recurrent pregnancy loss. Further studies in larger populations are needed to confirm the findings. © The Author(s), under exclusive licence to Indian Society of Hematology and Blood Transfusion 2023.
Related Docs
View other Related Docs
1. Determining the Association of Thrombophilic Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women, Gynecological Endocrinology (2020)
2. Association of Factor V Leiden and Prothrombin G20210a Polymorphisms in Women With Recurrent Pregnancy Loss in Isfahan Province, Iran, International Journal of Preventive Medicine (2018)
3. Study of Association Between Factor Xi Polymorphism and Recurrent Miscarriage in Iran Helal Infertility Center (Rouyesh) Patients, Journal of Payavard Salamat (2019)
4. Association Between Thrombophilia and Repeated Assisted Reproductive Technology Failures, Advanced Pharmaceutical Bulletin (2012)
5. The Study of Association Between Polymorphism of Tnf-Α Gene's Promoter Region and Recurrent Pregnancy Loss, Journal of Reproduction and Infertility (2018)
6. Association of Deficiency of Coagulation Factors (Prs, Prc, Atiii) and Fvl Positivity With Preeclampsia And/Or Eclampsia in Pregnant Women, International Journal of Hematology-Oncology and Stem Cell Research (2014)
7. Factor V Leiden, Factor V Cambridge, Factor Ii Ga20210, and Methylenetetrahydrofolate Reductase in Cerebral Venous and Sinus Thrombosis: A Case-Control Study, Journal of Research in Medical Sciences (2015)
8. Analysis of Relationship Between Tumor Necrosis Factor Alpha Gene (G308a Polymorphism) With Preterm Labor, International Journal of Preventive Medicine (2013)
Experts (# of related papers)
View all Related Experts
Mohammad Saadatnia (3)
Majid Hosseinzadeh (2)
Other Related Docs
9. Genotypes of European and Iranian Patients With Type 3 Von Willebrand Disease Enrolled in 3Winters-Ips, Blood Advances (2021)
10. Assessment of Β-Human-Derived Chorionic Gonadotrophic Hormone (Βhcg) and Pregnancy-Associated Plasma Protein a (Papp-A) Levels As Predictive Factors of Preeclampsia in the First Trimester Among Iranian Women: A Cohort Study, BMC Pregnancy and Childbirth (2019)
11. Evaluating the Challenges and Opportunities of Screening for Alpha Thalassemia Within the Beta Thalassemia Screening Program in the Islamic Republic of Iran; [بررسی چالشها و فرص تها ی غربالگری آلفا تالاسم ی در برنامهی غربالگری بتا تالاسمی در جمهور ی اسلامی ایران], Journal of Isfahan Medical School (2025)
12. The First Report of a Patient With Trisomy 4P and Monosomy 10Q, Archives of Iranian Medicine (2019)
13. Interactions of Spontaneous Abortion With Fto Gene and Dietary Carotenoids; a Case-Control Study, Journal of Nutritional Science (2024)
14. Association of Factor V Leiden Deficiency With Preeclampsia, Eclampsia in the Pregnant Women, Journal of Babol University of Medical Sciences (2014)
15. Genetic Thromboembolic Risk Factors Associated With Deep Vein Thrombosis in a Iranian Population, Journal of Isfahan Medical School (2011)
16. Recurrent Miscarriage in a Woman With Congenital Factor V Deficiency: A Case Report, BMC Pregnancy and Childbirth (2022)
17. Chrng Gene Mutations Found by Whole Exome Sequencing Are Related to Recurrent Pregnancy Loss, Human Gene (2023)
18. Family-Based Association Analysis Between Nonsyndromic Cleft Lip With or Without Cleft Palate and Irf6 Polymorphism in an Iranian Population, Clinical Oral Investigations (2015)
19. The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein a and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency, Advanced Biomedical Research (2023)
20. The Impact of Prothrombin (G20210a) Gene Mutation on Stroke in Youths, ARYA Atherosclerosis (2012)
21. Determining Genetic Variants in Children and Adolescents Suffering From Tetralogy of Fallot With a Positive Family History: Methodology, Acta Biomedica (2020)
22. Significant Association Between Nonsyndromic Cleft Lip With or Without Cleft Palate and Irf6rs2235371 Polymorphism in Iranian Familiar Population, Molecular Biology (2015)
23. Relationship of Lipid Regulatory Gene Polymorphisms and Dyslipidemia in a Pediatric Population: The Caspian Iii Study, Hormones (2018)
24. Significant Association Between Nonsyndromic Cleft Lip With or Without Cleft Palate and Irf6rs2235371 Polymorphism in Iranian Familiar Population, Molekuliarnaia biologiia (2015)
25. Chromosomal Abnormalities in Regions 8Q22 and 13Q32 Associated With Different Disorders in an Iranian Family, Journal of Sciences, Islamic Republic of Iran (2012)