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Cholesterol to Saturated Fat Index (Csi), Metabolic Parameters and Inflammatory Factors Among Obese Individuals Publisher Pubmed



Shakarami M1 ; Zaman BA2 ; Sedaghat A3 ; Qassem HMA4 ; Zedann YA5 ; Soud NA7 ; Adil M8 ; Shirvani S9 ; Nikbin N10
Authors
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Authors Affiliations
  1. 1. Department of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Basic Sciences, College of Pharmacy, University of Duhok, Kurdistan Region, Duhok, Iraq
  3. 3. Pedram Ataee Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandag, Iran
  4. 4. College of MLT, Ahl Al Bayt University, Kerbala, Iraq
  5. 5. Department of Radiology & amp
  6. 6. Sonar Techniques, Al-Noor University College, Nineveh, Iraq
  7. 7. Collage of Dentist, National University of Science and Technology, Dhi Qar, 64001, Iraq
  8. 8. Pharmacy College, Al-Farahidi University, Baghdad, Iraq
  9. 9. Department of Medicine, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
  10. 10. Iranian Cardiac Society, Tehran, Iran

Source: BMC Endocrine Disorders Published:2024


Abstract

Background: The role of dietary fat quality in promotion of cardiovascular diseases is studies before. However, the results are inconsistent. Recently, cholesterol to saturated fatty acid index (CSI) is suggested as a novel indicator of the atherogenicity and thrombogenicity potential of a diet. However, due to limited number of studies, in the current cross-sectional study, we aimed to evaluate the role of CSI in metabolic and inflammatory response among obese individuals. Methods: In the current cross-sectional study 488 obese individuals aged 18–50 years old were involved in volunteer based invitation from outpatient obesity clinics. Subjects underwent anthropometric assays including weight, height, waist circumference (WC) and body composition and their fasting blood sample were obtained for biochemical assessments including blood sugar, serum lipids, hs-CRP and IL-6 concentrations by commercial kits. Physical activity was also assessed by short form of international physical activity questionnaire (IPAQ). Results: According to our results, being at the top tetile of CSI was associated with higher anthropometric indices including weight, height, WC, FFM, and basal metabolic rate (BMR) compared with those at the lowest tertile (P < 0.05). Similarly, those at the highest category of CSI had significantly higher levels of serum glucose and hs-CRP both in crude and adjusted models in ANCOVA and in multinomial logistic regression models (P < 0.05). Conclusion: In the current study, for the first time, we identified the possible triggering role of dietary cholesterol to saturated fat index in increasing serum glucose and hs-CRP levels. due to cross-sectional design of the current study, causal inference is impossible. Further studies will help for better scientific justification. © The Author(s) 2024.
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