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Cardioprotective Effects of Total and Anthocyanin-Rich Extracts of Opuntia Ficus-Indica Fruit on Epinephrine-Induced Cardiac Injury in Rats Publisher



Safaeian L1 ; Sadeghidinani M2 ; Haghighatian Z3 ; Fatahian MB1 ; Khademizadeh M4
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pathology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  4. 4. Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Asian Pacific Journal of Tropical Biomedicine Published:2024


Abstract

Objective: To examine the effect of fruit extracts of Opuntia ficus-indica on epinephrine-induced myocardial injury in rats. Methods: Rats were pre-treated with hydroalcoholic and anthocyanin-rich extracts (250, 500, and 1 000 mg/kg) orally for 16 days. Epinephrine (2 mg/kg) was injected subcutaneously on days 15 and 16. Then ECG, heart rate, RR interval, cardiac histopathology, and serum parameters of cardiac damage and oxidative stress were evaluated. Results: Pretreatment with the hydroalcoholic and anthocyanin-rich extracts of Opuntia ficus-indica at doses of 500 and 1 000 mg/kg reversed epinephrine-induced changes in ECG, heart rate, RR interval, and cardiac histopathology, and attenuated creatine phosphokinase-MB activity and malondialdehyde level. The extracts at all doses diminished heart weight, lactate dehydrogenase, and aspartate aminotransferase, and also elevated total antioxidant capacity. However, 1 000 mg/kg of the anthocyanin-rich extract was more effective than the hydroalcoholic extract. Conclusions: Supplementation with fruit extracts of Opuntia ficus-indica, especially anthocyanin-rich extract, could protect against epinephrine-induced cardiac injury in rats by alleviating electrocardiographic, biochemical, histopathological, and oxidative stress parameters, and may be used in the treatment of cardiovascular diseases. © 2024 Asian Pacific Journal of Tropical Biomedicine.
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