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Asian Pacific Journal of Tropical Biomedicine Cardioprotective Effects of Pinus Eldarica Bark Extract on Adrenaline-Induced Myocardial Infarction in Rats Publisher



Safaeian L1 ; Haghighatian Z2 ; Zolfaghari B3 ; Amindeldar M1
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pathology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. 3. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Asian Pacific Journal of Tropical Biomedicine Published:2023


Abstract

Objective: To investigate the effect of Pinus eldarica bark extract on adrenaline-induced myocardial infarction. Methods: Hydroalcoholic extract was prepared using maceration method and its total phenolic content was determined using the Folin-ciocalteu method. Pretreatment was done by oral administration of 100, 200, and 400 mg/kg Pinus eldarica bark extract for 16 days in male Wistar rats. Injection of adrenaline (2 mg/kg, s.c.) was performed on the 15th and 16th days for induction of myocardial infarction. Lead II EEG was recorded. Serum cardiac marker enzymes and antioxidative parameters were evaluated and a histopathological examination of heart tissues was performed. Results: Pretreatment with Pinus eldarica bark extract especially at its high doses significantly lowered the ST-segment elevation, improved heart rate, and decreased RR interval in ECG pattern of rats with adrenaline-induced myocardial infarction. It declined serum markers of heart damage including aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase-MB, and also decreased lipid peroxidation marker, and heart weight while raising total antioxidant capacity and considerably improved histopathological alterations of the heart induced by adrenaline. Conclusions: Pinus eldarica bark extract shows beneficial cardioprotective and antioxidant effects against adrenaline-induced myocardial infarction. It can be further explored as a potential treatment for myocardial infarction. © 2023 Asian Pacific Journal of Tropical Medicine.
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