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8-Year Survival Analysis of Kidney Transplantation and Determining the Factors Affecting It in Kidney-Transplanted Patients in Noor Hospital in Isfahan, Iran



Askarishahi M1 ; Shahidi S2 ; Atapoor A2 ; Hemayati R3 ; Zeynali S1
Authors
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Authors Affiliations
  1. 1. Department of Biostatistics and Epidemiology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Internal Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Journal of Isfahan Medical School Published:2017

Abstract

Background: Kidney transplantation is the preferred treatment for most patients with end-stage renal disease (ESRD) and therefore, kidney transplantation survival analysis is important. The aim of this study was to determine the cumulative survival rate of renal transplantation and the factors affecting it. Methods: This was a historic cohort study including information of 381 patients with end-stage renal disease who underwent kidney transplantation surgery from December 2007 to March 2016 in Noor hospital, Isfahan, Iran. The Kaplan-Meier method, Log Rank test and Cox regression model were used for statistical analysis. Data analysis was carried out with R software, Version 3.1.0, at the significance level of P < 0.05. Findings: According to Kaplan-Mayer method, 1-, 3-, 5- and 8-year survival rates of transplanted kidney were estimated as 98.7, 93.3, 86.9, and 83.9 percent, respectively. The results of Cox regression model indicated that the time duration of dialysis before transplantation (P < 0.05), and the level of creatinine at the time of discharge from hospital (P < 0.05) had significant relationship with survival of transplanted kidney. Conclusion: The survival rate of the transplanted kidney calculated for this center was suitable in comparison with other transplant centers. The level of creatinine at the time of discharge from hospital and the time duration of dialysis prior to transplantation were the factors influencing survival of the graft. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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