Outcome of Renal Transplantation in Children: A Multi-Center National Report From Iran Publisher Pubmed



Otukesh H¹ ; Hoseini R¹ ; Rahimzadeh N¹ ; Fereshtehnejad SM² ; Simfroosh N¹ ; Basiri A¹ ; Sharifian M¹ ; Hashemi GH³ ; Falahzadeh H³ ; Derakhshan A³ ; Fazel M³ ; Reiesee D⁴ ; Sayedzadeh A⁴ ; Vazirian S⁴ Show All Authors Show Affiliations
Source: Pediatric Transplantation Published:2011

Abstract

The outcome of pediatric renal transplantation was previously reported by a single-center study at the year 2006. Therefore, we aimed to evaluate and report the characteristics and outcome of renal pediatric renal transplantation in a multi-center nationwide study. In this nationwide report, medical records of 907 children (≤18 yr) with renal transplantation in eight major pediatric transplant centers of Iran were recorded. These 907 patients received a total of 922 transplants. All children who failed to follow-up were excluded. Rather than baseline characteristics, graft and patient outcomes were considered for survival analysis. For further analysis, they were divided into two groups: patients who had graft survival time more than 10 yr (n = 91) and the ones with graft survival time of equal or less than 10 yr (n = 831). Of 922 recipients, 515 (55.8%) were boys and 407 (44.2%) were girls with the mean age of 13.10 (s.d. = 3.54) yr. DGF and AR were occurred in 10% and 39.5% of the transplanted children, respectively. Transplantation year, dialyzing status before transplantation, DGF, and AR were significant enough to predict graft survival in cox regression model (overall model: p < 0.001). Nowadays, there is a successful live donor pediatric renal transplantation in Iran. Graft survival has improved in our recipients and now the graft survival rates are near to international standards. © 2011 John Wiley & Sons A/S.