Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Eplerenone Treatment in Patients With Central Serous Retinopathy: A Double‑Blind Randomized Clinical Trial Publisher



Akhlaghi M1 ; Dehghani A1 ; Kianersi F1 ; Khalili MR2 ; Tohidi M1 ; Jahanbaniardakani H2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Journal of Current Ophthalmology Published:2024


Abstract

Purpose: To evaluate the efficacy of eplerenone in central serous chorioretinopathy (CSCR) patients in a clinical trial design. Methods: In this double‑blind clinical trial, naive acute CSCR patients were divided into two groups: treatment with eplerenone 25 mg daily in the 1st week followed by 50 mg for the next 3 weeks and placebo group. Best‑corrected visual acuity (BCVA), central macular thickness (CMT), macular volume (MV), and choroidal thickness (CT) were measured before and after 1 month of the intervention using the optical coherence tomography technique. Results: Thirty‑one CSCR (male: 23, female: 8) and 25 CSCR patients (male: 18, female: 7) with the mean age of 35.65 ± 5.94 and 37.08 ± 6.41 years were recruited and divided randomly into treatment and placebo groups, respectively. BCVA improved significantly in the treatment group (from 0.28 ± 0.26 to 0.11 ± 0.14, P = 0.002) compared with the placebo group (from 0.31 ± 0.26 to 0.21 ± 0.14, P = 0.052). Although CT, CMT, and MV improved significantly in each group, there were no significant differences between the groups. Conclusion: In this study, we found favorable short‑term clinical effects of eplerenone in acute CSCR patients, showing the pivotal role of mineralocorticoid receptors in the retina. © 2024 Journal of Current Ophthalmology.
Related Docs
View other Related Docs
1. Short-Term Effects of Photodynamic Therapy on Segmentation of Retinal Layers in Central Serous Chorioretinopathy, Advanced Biomedical Research (2021)
2. Effects of Propranolol in Patients With Central Serous Chorioretinopathy, Journal of Research in Medical Sciences (2008)
3. Topical Cyclosporine-A Versus Prednisolone for Herpetic Stromal Keratitis: A Randomized Controlled Trial, Acta Ophthalmologica (2019)
4. The Effect of Hesa-A (Natural Drug) on Visual Acuity in Age Related Macular Degeneration: A Randomized Double Blind Controlled Clinical Trial, African Journal of Traditional, Complementary and Alternative Medicines (2009)
5. Systemic Isotretinoin Therapy and Central Macular and Choroidal Thicknesses in Acne Vulgaris: Is There Any Association?, Cutaneous and Ocular Toxicology (2023)
6. Non-Steroidal Intravitreal Injection for Noninfectious Uveitic Cystoid Macular Edema: Systematic Review and Meta-Analysis, European Journal of Ophthalmology (2024)
7. Peripapillary and Macular Choroidal Thickness in Both Eyes of Patients With Acute Unilateral Retrobulbar Optic Neuritis, Taiwan Journal of Ophthalmology (2020)
8. Parapapillary Choroidal Microvascular Density in Acute Primary Angle-Closure and Primary Open-Angle Glaucoma: An Optical Coherence Tomography Angiography Study, British Journal of Ophthalmology (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Reza Akhlaghi (7)
Alireza Dehghani (5)
Other Related Docs
9. Intravitreal Bevacizumab for Management of Choroidal Osteoma Without Choroidal Neovascularization, Journal of Ophthalmic and Vision Research (2015)
10. Baseline Subfoveal Choroidal Thickness As an Indicator for Bevacizumab Outcomes in Central Retinal Vein Occlusion, Tehran University Medical Journal (2019)
11. Intima-Media Thickness Measurements of the Common Carotid Artery in Patients With Central Serous Chorioretinopathy: A Case-Control Study, Journal of Ophthalmology (2021)
12. Automated Evaluation of Parapapillary Choroidal Microvasculature in Ischemic Optic Neuropathy and Open Angle Glaucoma, Investigative Ophthalmology and Visual Science (2020)
13. Evaluating the Efficacy and Safety of Aflibercept Biosimilar (P041) Compared With Originator Product in Patients With Neovascular Age-Related Macular Degeneration, Ophthalmology Retina (2024)
14. Automated Evaluation of Parapapillary Choroidal Microvasculature in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma, American Journal of Ophthalmology (2021)
15. The Effect of Laser Diode Micropulse Laser in Patients With Acute Central Serous Retinopathy in Comparison With Control Group: A Clinical Trial Study, Journal of Isfahan Medical School (2019)
16. Central Serous Chorioretinopathy Risk Factors in an Iranian Cohort: A Case-Control Study, Journal of Ophthalmic and Vision Research (2023)
17. Effect of Different Treatments on Retinal Thickness Changes in Patients With Multiple Sclerosis: A Review, CNS Neuroscience and Therapeutics (2025)
18. Corneal Cross-Linking for Keratoconus: Evaluation of the Retina and Choroid, European Journal of Ophthalmology (2022)
19. Comparison of Indocyanine Green Angiography and Fluorescein Angiography for Imaging of Central Serous Chorioretinopathy Patients As Candidates for Photodynamic Therapy; [Comparaison De L'angiographie Au Vert D'indocyanine Et De L'angiographie a La Fluoresceine Pour L'imagerie Des Patients Atteints De Chorioretinopathie Sereuse Centrale Candidats a La Therapie Photodynamique], Journal Francais d'Ophtalmologie (2022)