Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Flaxseed Powder on Cardiovascular Risk Factor in Dyslipidemic and Hypertensive Patients Publisher



Haghighatsiar N1 ; Askari G1 ; Sarafbank S1 ; Feizi A2 ; Keshmiri H3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Epidemiology and Biostatistics, Isfahan Endocrine and Metabolism Research Center, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. University of Medical Sciences, Shiraz, Iran

Source: International Journal of Preventive Medicine Published:2019


Abstract

Background: Hyperlipidemia and hypertension are the most important causes of ischemic heart disease. There is evidence that flaxseed powder can improve lipid profile and blood pressure. In this study, we want to investigate the effects of flaxseed powder consumption on patients with hyperlipidemia and hypertension. Methods: This randomized double-blind placebo-controlled clinical trial was performed on 80 hyperlipidemic and hypertensive patients (men and women between 20 and 60 years old). In this study, participants were recruited from Imam Khomeini hospital clinics of Shiraz University of Medical Sciences in 2017 randomly allocated to flaxseed powder group and placebo group. The intervention group received 36 g of flaxseed sachet (n = 40), and control group received 12 g placebo sachet (n = 40) for 8 weeks. Serum lipid profiles, blood pressure, fasting blood sugar, and anthropometric indices were measured. Data were analyzed by using SPSS. Results: We found significant reduction (P < 0.001) in anthropometric indices (waist circumference and waist-to-hip ratio) and lipid profiles (triglycerides [P = 0.015], total cholesterol [P = 0.018], and low-density lipoprotein [P < 0.001]) within flaxseed group in comparison with placebo group. Conclusions: Based on beneficial effects of flaxseed on cardiovascular risk factors, it seems that flaxseed consumption can be considered as a useful therapeutic approach for reducing lipid profile and anthropometric indices. © 2019 International Journal of Preventive Medicine.
Related Docs
View other Related Docs
1. Effect of Flaxseed on Blood Lipid Level in Hyperlipidemic Patients, Reviews on Recent Clinical Trials (2015)
2. Effects of Breads Containing Flaxseeds on Serum Levels of Apelin and Lipids in Hyperlipidemic Patients, Iranian Journal of Nutrition Sciences and Food Technology (2021)
3. Impact of Flaxseed Supplementation on Plasma Lipoprotein(A) Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2020)
4. Effects of Flaxseed on Blood Lipids in Healthy and Dyslipidemic Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Problems in Cardiology (2022)
5. Can Flaxseed Supplementation Affect Circulating Adipokines in Adults? an Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, Frontiers in Nutrition (2023)
6. Effect of Flaxseed Supplementation on Markers of Inflammation and Endothelial Function: A Systematic Review and Meta-Analysis, Cytokine (2020)
7. Effects of Flaxseed Supplementation on Inflammatory Biomarkers: A Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials, Prostaglandins and Other Lipid Mediators (2024)
8. Effect of Flaxseed Oil on Glycemic Control and Inflammatory Markers in Overweight Adults With Pre-Diabetes: A Double-Blind Randomized Controlled Clinical Trial, Journal of Herbal Medicine (2020)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (33)
Noushin Mohammadifard (31)
Other Related Docs
9. The Effects of Phytochemicals and Herbal Bio-Active Compounds on Tumour Necrosis Factor-Α in Overweight and Obese Individuals: A Clinical Review, Inflammopharmacology (2022)
10. The Effects of Cashew Nut Intake on Lipid Profile and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
11. The Effect of Herbal Medicine and Natural Bioactive Compounds on Plasma Adiponectin: A Clinical Review, Advances in Experimental Medicine and Biology (2021)
12. Regulation of Apolipoprotein B by Natural Products and Nutraceuti-Cals: A Comprehensive Review, Current Medicinal Chemistry (2021)
13. The Efficacy of Sour Tea (Hibiscus Sabdariffa L.) on Selected Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Phytotherapy Research (2020)
14. What Is the Impact of Cinnamon Supplementation on Blood Pressure? a Systematic Review and Meta-Analysis, Endocrine, Metabolic and Immune Disorders - Drug Targets (2021)
15. Evaluating the Effects of Acarbose on Anthropometry Indexes and Metabolic Markers in Patients With Metabolic Syndrome in Comparison to Placebo, in Isfahan City, Iran, Journal of Isfahan Medical School (2018)
16. Soy Inclusion in the Diet Improves Features of the Metabolic Syndrome: A Randomized Cross-Over Study in Postmenopausal Women, Iranian Journal of Diabetes and Lipid Disorders (2007)
17. Effect of Sour Tea Supplementation on Liver Enzymes, Lipid Profile, Blood Pressure, and Antioxidant Status in Patients With Non-Alcoholic Fatty Liver Disease: A Double-Blind Randomized Controlled Clinical Trial, Phytotherapy Research (2021)
18. The Effect of Glucomannan Supplementation on Lipid Profile in Adults: A Grade-Assessed Systematic Review and Meta-Analysis, BMC Cardiovascular Disorders (2024)
19. Allium Hirtifolium Boiss: Radical Scavenging Property and the Lowering Effects on Blood Fibrinogen and Factor Vii, Life Science Journal (2012)
20. Effect of Fenugreek Seeds on Blood Glucose and Lipid Profiles in Type 2 Diabetic Patients, International Journal for Vitamin and Nutrition Research (2009)
21. The Effect of Quercetin Supplementation on the Components of Metabolic Syndrome in Adults: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Journal of Functional Foods (2024)
22. The Association Between Non Soy Legume Consumption and Cardiovascular Risk Factors, Journal of Babol University of Medical Sciences (2015)
23. Folic Acid Supplementation and Blood Pressure: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of 41,633 Participants, Critical Reviews in Food Science and Nutrition (2023)
24. Does Alpha-Lipoic Acid Affect Lipid Profile? a Meta-Analysis and Systematic Review on Randomized Controlled Trials, European Journal of Pharmacology (2019)
25. Longitudinal Association of Dietary Carbohydrate and the Risk Cardiovascular Disease: A Dose-Response Meta-Analysis, Critical Reviews in Food Science and Nutrition (2022)
26. Evaluation of the Effects of Roselle (Hibiscus Sabdariffa L.) on Oxidative Stress and Serum Levels of Lipids, Insulin and Hs-Crp in Adult Patients With Metabolic Syndrome: A Double-Blind Placebo-Controlled Clinical Trial, Journal of Complementary and Integrative Medicine (2016)
27. The Effect of Green Coffee Extract Supplementation on Anthropometric Measures in Adults: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Medicine (2020)
28. Antihyperlipidemic Effects of Sesamum Indicum L. in Rabbits Fed a High-Fat Diet, The Scientific World Journal (2013)
29. The Effects of Selenium Supplementation on Blood Lipids and Blood Pressure in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Control Trials, Journal of Trace Elements in Medicine and Biology (2022)
30. The Effects of Cranberry on Cardiovascular Metabolic Risk Factors: A Systematic Review and Meta-Analysis, Clinical Nutrition (2020)
31. Medicinal Plants and Bioactive Natural Compounds As Inhibitors of Hmg-Coa Reductase: A Literature Review, BioFactors (2020)
32. Effects of Daily Consumption of Cashews on Oxidative Stress and Atherogenic Indices in Patients With Type 2 Diabetes: A Randomized, Controlled-Feeding Trial, International Journal of Endocrinology and Metabolism (2019)
33. Effects of Shrimp Oil on Cardio-Metabolic Risk Factors in Children and Adolescents, International Journal for Vitamin and Nutrition Research (2023)
34. Intake of Legumes and the Risk of Cardiovascular Disease: Frailty Modeling of a Prospective Cohort Study in the Iranian Middle-Aged and Older Population, European Journal of Clinical Nutrition (2016)
35. Clinical Effects of Rhus Coriaria Fruits on Dyslipidemia308 in Adolescents: A Triple-Blinded Randomized Placebo-Controlled Trial, Medical archives (Sarajevo, Bosnia and Herzegovina) (2014)
36. Effect of Garlic Powder Supplementation on Blood Pressure and Hs-C-Reactive Protein Among Nonalcoholic Fatty Liver Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Trial, Food Science and Nutrition (2021)
37. Effects of Ferulago Angulata Extract on Serum Lipids and Lipid Peroxidation, Evidence-based Complementary and Alternative Medicine (2014)
38. L-Arginine Supplementation and Risk Factors of Cardiovascular Diseases in Healthy Men: A Double-Blind Randomized Clinical Trial, F1000Research (2017)
39. Inverse Association of Legume Consumption and Dyslipidemia: Isfahan Healthy Heart Program, Journal of Clinical Lipidology (2014)
40. Effect of Sesame Supplementation on Body Composition and Lipid Profile in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2024)
41. Effects of Dietary Whole Grain, Fruit, and Vegetables on Weight and Inflammatory Biomarkers in Overweight and Obese Women, Eating and Weight Disorders (2020)
42. Effects of Stevia Consumption on Appetite in Adults: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Obesity Reviews (2025)
43. Effects of Cigarette Smoking on Postprandial Triglyceride in Healthy Smokers, Iranian Journal of Diabetes and Lipid Disorders (2010)
44. Does Supplementation With Pine Bark Extract Improve Cardiometabolic Risk Factors? a Systematic Review and Meta-Analysis, BMC Complementary Medicine and Therapies (2025)
45. Therapeutic Effect of Fenugreek Supplementation on Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Clinical Trials, Heliyon (2024)
46. Herbs With Anti-Lipid Effects and Their Interactions With Statins As a Chemical Antihyperlipidemia Group Drugs: A Systematic Review, ARYA Atherosclerosis (2015)
47. Nutraceuticals in Hyperlipidemic Children: A Systematic Review and Meta-Analysis, International Journal of Pediatrics (2016)
48. The Effect of Soy Products on Circulating Adiponectin and Leptin Concentration in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, International Journal of Clinical Practice (2021)
49. Association of the Elderly Dietary Index With Cardiovascular Disease Risk Factors in Elderly Men: A Cross-Sectional Study, Nutrition and Dietetics (2019)
50. A Systematic Review on Safety and Drug Interaction of Herbal Therapy in Hyperlipidemia: A Guide for Internist, Acta Biomedica (2015)