Innovative Applications of Mxenes in Dialysis: Enhancing Filtration Efficiency Publisher Pubmed



Javaherchi P¹ ; Zarepour A² ; Khosravi A³ ; Heydari P¹ ; Iravani S⁴ ; Zarrabi A^{5, 6} Show Affiliations
Source: Nanoscale Published:2024

Abstract

MXenes, a family of two-dimensional transition metal carbides and nitrides, exhibit exceptional properties such as high electrical conductivity, large surface area, and chemical versatility, making them ideal candidates for various dialysis applications. One prominent application of MXenes lies in the efficient removal of toxic metals and harmful dyes from wastewater. Their unique structure allows for rapid adsorption and selective separation, significantly improving purification processes. MXenes show great promise in the therapeutic management of acute kidney injury, where their biocompatibility and ability to facilitate toxin removal can mitigate damage to renal tissues. In hemodialysis, MXenes can enhance membrane performance through improved permeability and selectivity, leading to more effective clearance of waste products. Despite the potential of MXene-based composites in dialysis applications, several challenges loom large on the horizon. The stability of MXenes in physiological environments is a critical concern, as they can undergo oxidation or degradation, which may compromise their functionality over time. The scalability of synthesis processes remains a significant barrier; producing high-quality MXene materials in sufficient quantities for clinical use is not yet fully realized. Moreover, ensuring biocompatibility is paramount, as any adverse reactions could lead to inflammation or other complications in patients. The integration of MXenes into existing dialysis systems requires meticulous engineering to maintain optimal filtration properties while avoiding clogging or fouling. The future of MXenes and their composites in dialysis presents a promising horizon, teeming with potential innovations. The development of hybrid materials that utilize MXenes alongside other nanomaterials can lead to multifunctional systems, capable of addressing multiple challenges faced in dialysis treatments. Advancements in fabrication techniques may allow for tailored porosity, enabling customized dialysis solutions for individual patients. Research into surface modifications and composites can enhance their stability and functionality, potentially overcoming current limitations. The purpose of this review is to provide a comprehensive understanding of the current landscape of MXenes in dialysis, highlighting their applications, challenges, and future directions. This review explores the diverse applications of MXenes in the field of dialysis, focusing on their roles in the removal of toxic metals and dyes, therapy for acute kidney injury, and hemodialysis enhancement. © 2025 The Royal Society of Chemistry.