Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Calcium-Vitamin D Co-Supplementation Affects Metabolic Profiles, But Not Pregnancy Outcomes, in Healthy Pregnant Women Publisher



Asemi Z1 ; Samimi M2 ; Siavashani MA3 ; Mazloomi M4 ; Tabassi Z2 ; Karamali M4 ; Jamilian M5, 6 ; Esmaillzadeh A7, 8, 9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Gynecology and Obstetrics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  4. 4. Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran
  6. 6. Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
  7. 7. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Preventive Medicine Published:2016


Abstract

Background: Pregnancy is associated with unfavorable metabolic profile, which might in turn result in adverse pregnancy outcomes. The current study was designed to evaluate the effects of calcium plus Vitamin D administration on metabolic status and pregnancy outcomes in healthy pregnant women. Methods: This randomized double-blind placebo-controlled clinical trial was performed among 42 pregnant women aged 18–40 years who were at week 25 of gestation. Subjects were randomly allocated to consume either 500 mg calcium-200 IU cholecalciferol supplements (n = 21) or placebo (n = 21) for 9 weeks. Blood samples were obtained at the onset of the study and after 9-week trial to determine related markers. Post-delivery, the newborn’s weight, length, and head circumference were measured during the first 24 h after birth. Results: Consumption of calcium-Vitamin D co-supplements resulted in a significant reduction of serum high-sensitivity C-reactive protein levels compared with placebo (−1856.8 ± 2657.7 vs.707.1 ± 3139.4 μg/mL, P = 0.006). We also found a significant elevation of plasma total antioxidant capacity (89.3 ± 118.0 vs. −9.4 ± 164.9 mmol/L, P = 0.03), serum 25-hydroxyvitamin D (2.5 ± 3.5 vs. −1.7 ± 1.7 ng/mL, P < 0.0001), and calcium levels (0.6 ± 0.6 vs. −0.1 ± 0.4 mg/dL, P < 0.0001). The supplementation led to a significant decrease in diastolic blood pressure (−1.9 ± 8.3 vs. 3.1 ± 5.2 mmHg, P = 0.02) compared with placebo. No significant effect of calcium-Vitamin D co-supplements was seen on other metabolic profiles. We saw no significant change of the co-supplementation on pregnancy outcomes as well. Conclusions: Although calcium-Vitamin D co-supplementation for 9 weeks in pregnant women resulted in improved metabolic profiles, it did not affect pregnancy outcomes. © 2016 International Journal of Preventive Medicine.
Related Docs
View other Related Docs
1. Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein, Insulin Resistance, and Biomarkers of Oxidative Stress in Pregnant Women, Journal of Nutrition (2013)
2. Effects of Vitamin D Supplementation on Glucose Metabolism, Lipid Concentrations, Inflammation, and Oxidative Stress in Gestational Diabetes: A Double-Blind Randomized Controlled Clinical Trial1-3, American Journal of Clinical Nutrition (2013)
3. Effects of Calcium-Vitamin D Co-Supplementation on Glycaemic Control, Inflammation and Oxidative Stress in Gestational Diabetes: A Randomised Placebo-Controlled Trial, Diabetologia (2014)
4. The Effect of Multi Mineral‑Vitamin D Supplementation on Pregnancy Outcomes in Pregnant Women at Risk for Pre‑Eclampsia, International Journal of Preventive Medicine (2015)
5. Favorable Effects of Vitamin D Supplementation on Pregnancy Outcomes in Gestational Diabetes: A Double Blind Randomized Controlled Clinical Trial, Hormone and Metabolic Research (2014)
6. Calcium Plus Vitamin D Supplementation Affects Pregnancy Outcomes in Gestational Diabetes: Randomized, Double-Blind, Placebo-Controlled Trial, Public Health Nutrition (2016)
7. The Effects of Vitamin D, K and Calcium Co-Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Overweight Type 2 Diabetic Patients With Chd, British Journal of Nutrition (2016)
8. The Effects of Vitamin D Plus Calcium Supplementation on Metabolic Profiles, Biomarkers of Inflammation, Oxidative Stress and Pregnancy Outcomes in Pregnant Women at Risk for Pre-Eclampsia, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association (2016)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (21)
Reza Amani (10)
Other Related Docs
9. Calcium Plus Vitamin D Supplementation Influences Biomarkers of Inflammation and Oxidative Stress in Overweight and Vitamin D-Deficient Women With Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Clinical Endocrinology (2015)
10. The Effect of Vitamin D Supplementation on Oxidative Stress and Inflammatory Biomarkers in Pregnant Women: A Systematic Review and Meta-Analysis of Clinical Trials, BMC Pregnancy and Childbirth (2022)
11. Magnesium Supplementation Affects Metabolic Status and Pregnancy Outcomes in Gestational Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, American Journal of Clinical Nutrition (2015)
12. Effect of Daily Consumption of Probiotic Yogurt on Oxidative Stress in Pregnant Women: A Randomized Controlled Clinical Trial, Annals of Nutrition and Metabolism (2012)
13. Effect of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D and Homeostatic Model of Insulin Resistance Levels in Healthy Pregnancy: A Systematic Review and Meta-Analysis, Iranian Journal of Medical Sciences (2023)
14. Valuation of Vitamin D Level at the End of First Trimester and Its Relation With Anemia, Bacterial Vaginosis, and Toothache in Pregnant Mothers, Journal of Isfahan Medical School (2015)
15. Calcium Plus Vitamin D Supplementation Affects Glucose Metabolism and Lipid Concentrations in Overweight and Obese Vitamin D Deficient Women With Polycystic Ovary Syndrome, Clinical Nutrition (2015)
16. A Systematic Review on the Effects of Maternal Calcium Supplementation on Offspring’S Blood Pressure, Journal of Research in Medical Sciences (2015)
17. Effects of Selenium Supplementation on Glucose Homeostasis, Inflammation, and Oxidative Stress in Gestational Diabetes: Randomized, Double-Blind, Placebo-Controlled Trial, Nutrition (2015)
18. Association Between Maternal Plasma Total Antioxidant Capacity and Dietary Antioxidants Intake With Birth Size Outcomes, Journal of Tropical Pediatrics (2023)
19. Multivitamin Versus Multivitamin-Mineral Supplementation and Pregnancy Outcomes: A Single-Blind Randomized Clinical Trial, International Journal of Preventive Medicine (2014)
20. The a Ssociation of 25-Hydroxy Vitamin D Level in Mothers With Term and Preterm Delivery and Their Neonates, Journal of Research in Medical Sciences (2020)
21. Comparison of Sun Exposure Versus Vitamin D Supplementation for Pregnant Women With Vitamin D Deficiency, Journal of Maternal-Fetal and Neonatal Medicine (2019)
22. Is the Association Between Vitamin D and Metabolic Syndrome Independent of Other Micronutrients?, International Journal for Vitamin and Nutrition Research (2015)
23. Zinc Supplementation and the Effects on Metabolic Status in Gestational Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Diabetes and its Complications (2015)
24. Effect of Vitamin D Supplementation on Weight Loss, Glycemic Indices, and Lipid Profile in Obese and Overweight Women: A Clinical Trial Study, International Journal of Preventive Medicine (2018)
25. Genetic Variations in Vdr Could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity Among Breast Cancer Women: A Randomized Double Blind Controlled Trial, Asian Pacific Journal of Cancer Prevention (2019)
26. Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients With Major Depressive Disorder: A Randomized, Controlled Clinical Trial, Journal of Nutrition (2016)
27. A Randomized Controlled Clinical Trial Investigating the Effect of Dash Diet on Insulin Resistance, Inflammation, and Oxidative Stress in Gestational Diabetes, Nutrition (2013)
28. Effect of Calcium and Vitamin D Co-Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis, Clinical Therapeutics (2020)
29. Effects of Calcium Plus Vitamin D Supplementation on Anthropometric Measurements and Blood Pressure in Vitamin D Insufficient People With Type 2 Diabetes: A Randomized Controlled Clinical Trial, Journal of the American College of Nutrition (2015)
30. Vitamin D and Biomarkers of Inflammation and Oxidative Stress Among Pregnant Women: A Systematic Review of Observational Studies, BMC Immunology (2023)
31. Probiotic Supplementation in Diabetic Hemodialysis Patients Has Beneficial Metabolic Effects, Kidney International (2017)
32. Effect of Daily Consumption of Probiotic Yoghurt on Serum Levels of Calcium, Iron and Liver Enzymes in Pregnant Women, International Journal of Preventive Medicine (2013)
33. The Effect of Vitamin D and Calcium Supplementation on Inflammatory Biomarkers, Estradiol Levels and Severity of Symptoms in Women With Postpartum Depression: A Randomized Double-Blind Clinical Trial, Nutritional Neuroscience (2022)
34. Clinical and Metabolic Response to Probiotic Administration in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial, Nutrition (2016)
35. Maternal Vitamin D Status and Risk of Pre-Eclampsia: A Systematic Review and Meta-Analysis, Journal of Clinical Endocrinology and Metabolism (2013)
36. Maternal Calcium Supplementation and Its Effect on Offspring Blood Pressure: A Systematic Review on the Current Evidence, Journal of Isfahan Medical School (2015)
37. Effects of Dash Diet on Lipid Profiles and Biomarkers of Oxidative Stress in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial, Nutrition (2014)
38. Effects of Long-Term Folate Supplementation on Metabolic Status and Regression of Cervical Intraepithelial Neoplasia: A Randomized, Double-Blind, Placebo-Controlled Trial, Nutrition (2016)
39. Effect of the Cumin Cyminum L. Intake on Weight Loss, Metabolic Profiles and Biomarkers of Oxidative Stress in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Annals of Nutrition and Metabolism (2015)
40. Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients, International Journal of Radiation Oncology Biology Physics (2015)
41. Effects of Folate Supplementation on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2/3 in Overweight and Obese Women: A Randomized Double-Blind Placebo-Controlled Trial, European Journal of Clinical Nutrition (2022)
42. The Relationship Between Maternal Vitamin D Levels and Osteopenia Development in Preterm Infants: A Cross-Sectional Study, International Journal of Reproductive BioMedicine (2024)
43. Impact of Dietary Calcium Supplement on Circulating Lipoprotein Concentrations and Atherogenic Indices in Overweight and Obese Individuals: A Systematic Review, Journal of Dietary Supplements (2019)
44. Effects of Vitamin D Deficiency Treatment on Metabolic Markers in Hashimoto Thyroiditis Patients, Journal of Research in Medical Sciences (2016)
45. Effects of Ramadan Fasting on Glucose Homeostasis, Lipid Profiles, Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome in Kashan, Iran, Archives of Iranian Medicine (2015)
46. Effects of Vitamin D Deficiency Treatment on Metabolic Markers in Hashimoto Thyroiditis Patients, Journal of Research in Medical Sciences (2017)
47. Editorial Expression of Concern: Effects of Calcium–Vitamin D Co-Supplementation on Glycaemic Control, Inflammation and Oxidative Stress in Gestational Diabetes: A Randomised Placebo-Controlled Trial (Diabetologia, 10.1007/S00125-014-3293-X), Diabetologia (2024)
48. The Effect of Vitamin D Supplementation on Body Composition in Nursing Mothers With Overweight or Obesity: A Randomized Double-Blind Placebo-Controlled Clinical Trial, BMC Nutrition (2023)
49. Postpartum Depression and Vitamin D: A Systematic Review, Critical Reviews in Food Science and Nutrition (2019)
50. Associations Between Dietary Energy Density in Mothers and Growth of Breastfeeding Infants During the First 4 Months of Life, Journal of the American College of Nutrition (2018)