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T-Cell Molecular Modulation Responses in Atherosclerosis Anergy Publisher Pubmed



Pakzad B1 ; Rajae E2 ; Shahrabi S3 ; Mansournezhad S4 ; Davari N4 ; Azizidoost S4 ; Saki N4
Authors
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Authors Affiliations
  1. 1. Internal Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Rheumatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  4. 4. Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Lab Medicine Published:2021


Abstract

Atherosclerosis continues to be a major cause of death in patients with cardiovascular diseases. The cooperative role of immunity has been recently considered in atherosclerotic plaque inflammation, especially adaptive immune response by T cells. In this review, we examine the possible role of T cells in atherosclerosis-mediated inflammation and conceivable therapeutic strategies that can ameliorate complications of atherosclerosis. The cytokines secreted by T-lymphocyte subsets, different pathophysiological profiles of microRNAs (miRs), and the growth factor/receptor axis have diverse effects on the inflammatory cycle of atherosclerosis. Manipulation of miRNA expression and prominent growth factor receptors involved in inflammatory cytokine secretion in atherosclerosis can be considered diagnostic biomarkers in the induction of anergy and blockade of atherosclerotic development. This manuscript reviews immunomodulation of T cells responses in atherosclerosis anergy. © American Society for Clinical Pathology 2020
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