Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Inflammation-Induced Atherosclerosis As a Target for Prevention of Cardiovascular Diseases From Early Life Publisher



Kelishadi R1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Preventive Cardiology Department, Isfahan Cardiovascular Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Open Cardiovascular Medicine Journal Published:2010


Abstract

Atherogenesis starts from the fetal life, and its natural course consists of interrelations between traditional risk factors and inflammatory, immune, and endothelial biomarkers. Even the early-stages of atherosclerotic lesions, i.e. fatty streaks present the features of chronic inflammation. Markers of inflammation are associated with insulin resistance and major atherosclerosis risk factors. Several studies have confirmed a relationship between surrogate markers of future cardiovascular disease with childhood obesity, notably abdominal obesity, as well as with the degree of obesity. Moreover, functional and structural changes are documented in arteries of children with a familial predisposition to atherosclerotic diseases; these changes are associated with clusters of inflammatory factors and markers of oxidation. In addition to the development of atheromatous plaques, inflammation also plays an essential role in the destabilization of artery plaques, and in turn in the occurrence of acute thrombo-embolic disorders. Markers of inflammation can provide predictive clinical information about outcomes of patients with acute coronary syndromes, independent of the extent of myocardial damage. Moreover, serum levels of the inflammatory markers might add prognostic information provided by traditional risk factors. Platelets have an important role in vascular inflammation and atherosclerosis and in the formation of mural thrombi. As lifestyle modification trials have been successful in decreasing endothelial dysfunction and the level of markers of inflammation among children and adolescents, it is suggested that in addition to expanding pharmacological therapies considered for secondary prevention of atherosclerotic diseases aiming to control the inflammatory process, the importance of primordial/primary prevention of atherosclerosis should be underscored. © Roya Kelishadi.
Related Docs
View other Related Docs
1. Effects of Adenoidectomy on Markers of Endothelial Function and Inflammation in Normal-Weight and Overweight Prepubescent Children With Sleep Apnea, Journal of Research in Medical Sciences (2011)
2. Effects of a Lifestyle Modification Trial Among Phenotypically Obese Metabolically Normal and Phenotypically Obese Metabolically Abnormal Adolescents in Comparison With Phenotypically Normal Metabolically Obese Adolescents, Maternal and Child Nutrition (2010)
3. Acute and Long Term Effects of Grape and Pomegranate Juice Consumption on Endothelial Dysfunction in Pediatric Metabolic Syndrome, Journal of Research in Medical Sciences (2011)
4. A Review on the Genetic, Environmental, and Lifestyle Aspects of the Early-Life Origins of Cardiovascular Disease, Current Problems in Pediatric and Adolescent Health Care (2014)
5. The Relationship Between Air Pollution and Serum Level of Thrombomodulin and Tissue Factor in a Representative Sample of Adolescents Aged 10-18 Years in Isfahan, Iran, Journal of Isfahan Medical School (2010)
6. Association of Changes in Oxidative and Proinflammatory States With Changes in Vascular Function After a Lifestyle Modification Trial Among Obese Children, Clinical Chemistry (2008)
7. Lifestyle and Environmental Factors Associated With Inflammation, Oxidative Stress and Insulin Resistance in Children, Atherosclerosis (2009)
8. Overweight, Air and Noise Pollution: Universal Risk Factors for Pediatric Pre-Hypertension, Journal of Research in Medical Sciences (2011)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (42)
Masoumeh Sadeghi (19)
Other Related Docs
9. Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10-18 Years Old, Clinical Chemistry (2007)
10. Investigation of the Lipid-Modifying and Antiinflammatory Effects of Cornus Mas L. Supplementation on Dyslipidemic Children and Adolescents, Pediatric Cardiology (2013)
11. The Thickness of the Intimal and Medial Layers of the Carotid Arteries, and the Index of Left Ventricular Mass, in Children of Patients With Premature Coronary Arterial Disease, Cardiology in the Young (2007)
12. Interleukin-6 and E-Selectin in Acute Coronary Syndromes and Stable Angina Pectoris: A Comparative Study, Herz (2012)
13. Factors Associated With Insulin Resistance and Non-Alcoholic Fatty Liver Disease Among Youths, Atherosclerosis (2009)
14. Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation, Acta Cardiologica (2023)
15. Natural Remedies That Offset Alpha-Linolenic Acid (Ala) Deficiency in Cardiovascular Hallmarks and Complications, Properties and Uses of Linolenic Acid (2023)
16. Dietary Patterns and Markers of Systemic Inflammation Among Iranian Women, Journal of Nutrition (2007)
17. Association Between the Platelet-To-Lymphocyte Ratio and the No-Reflow Phenomenon and Thrombolysis in Myocardial Infarction Flow 3 After Primary Percutaneous Coronary Intervention in Patients With St-Segment Elevation Myocardial Infarction, Iranian Heart Journal (2017)
18. The Prevalence of Impaired Fasting Glucose and Type 2 Diabetes in a Population-Based Sample of Overweight/Obese Children in the Middle East, Pediatric Diabetes (2010)
19. The Role of Serum Levels of Microrna-21 and Matrix Metalloproteinase-9 in Patients With Acute Coronary Syndrome, Molecular and Cellular Biochemistry (2016)
20. Prognostic Value of Circulating Macrophage Inhibitory Cytokine 1-Growth Differentiation Factor 15 (Mic-1/Gdf15) in Obesity: Relation With Vascular Endothelial Growth Factor (Vegf) and Markers of Oxidative Stress, Nutrition and Health (2023)
21. Prevalence of Different Metabolic Phenotypes of Obesity in Iranian Children and Adolescents: The Caspian V Study, Journal of Diabetes and Metabolic Disorders (2018)
22. Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts, Current Problems in Cardiology (2024)
23. Is Impaired Fasting Glucose Associated With Increased Risk of Coronary Aterosclerosis?, Acta Medica Iranica (2008)
24. Hematological Inflammatory Markers in Patients With Clinically Confirmed Familial Hypercholesterolemia, BioMed Research International (2022)
25. First Report on the Lipid Profile Late After Kawasaki Disease in Iranian Children, International Journal of Preventive Medicine (2014)
26. Can a Trial of Motivational Lifestyle Counseling Be Effective for Controlling Childhood Obesity and the Associated Cardiometabolic Risk Factors?, Pediatrics and Neonatology (2012)
27. Improvement of Hypertension, Endothelial Function and Systemic Inflammation Following Short-Term Supplementation With Red Beet (Beta Vulgaris L.) Juice: A Randomized Crossover Pilot Study, Journal of Human Hypertension (2016)
28. Association of Cell Blood Counts and Cardiometabolic Risk Factors Among Young Obese Children, Saudi Medical Journal (2010)
29. Trend of Atherosclerosis Risk Factors in Children of Isfahan, Asian Cardiovascular and Thoracic Annals (2001)
30. Epicardial Fat Thickness and Severity of Coronary Heart Disease in Patients With Diabetes Mellitus Type Ii, ARYA Atherosclerosis (2018)
31. Is Lp(A), As Predictor of Severity of Coronary Artery Disease?, Journal of Isfahan Medical School (2009)
32. Ldl Fatty Acids Composition As a Risk Biomarker of Cardiovascular Disease, Artery Research (2017)
33. A Novel Inflammatory Signaling Pathway in Patients With Slow Coronary Flow: Nf-Κb/Il-1Β/Nitric Oxide, Cytokine (2021)
34. Correlation of Echocardiographic Epicardial Fat Thickness With Severity of Coronary Artery Disease-An Observational Study; [Koroner Arter Hastaliginin Siddeti Ile Ekokardiyografik Epikardiyal Yag Kalinliginin Iliskisi-Gozlemsel Bir Calisma], Anadolu Kardiyoloji Dergisi (2012)
35. Comparing Heart Rate Reserve and High-Sensitivity C-Reactive Protein in Patients With and Without Metabolic Syndrome, Journal of Isfahan Medical School (2015)
36. Correlation of Circulating Inflammatory Markers, Ghrelin, Adiponectin With Obesity Indices in Subjects With Metabolic Syndrome, Pakistan Journal of Medical Sciences (2013)
37. Correlation Between Body Fat Distribution, Plasma Lipids and Apolipoproteins With the Severity of Coronary Involvement in Patients With Stable Angina, ARYA Atherosclerosis (2011)
38. Comparison of Epicardial Fat Thickness in Patients With Acute Coronary Syndrome or Chronic Stable Angina and Normal Individuals, Journal of Isfahan Medical School (2012)
39. Genetics of Familial Combined Hyperlipidemia (Fchl) Disorder: An Update, Biochemical Genetics (2022)
40. Evaluation of Fat Cell's Size, Number and Their Mediators in Ischemic Heart Disease Patients, Journal of Isfahan Medical School (2010)
41. Reference Curves of Anthropometric Indices and Serum Lipid Profiles in Representative Samples of Asian and European Children, Archives of Medical Science (2008)
42. Relationship Between Metabolic Syndrome and Angiographic Severity of Coronary Artery Disease, ARYA Atherosclerosis (2016)
43. In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons, Circulation: Cardiovascular Genetics (2015)
44. Association Between Hdl Particles Size and Myeloperoxidase/ Paraoxonase-1 (Mpo/Pon1) Ratio in Patients With Acute Coronary Syndrome, Acta Medica Iranica (2013)
45. Atherosclerosis: Process, Indicators, Risk Factors and New Hopes, International Journal of Preventive Medicine (2014)
46. Association of Serum Ceruloplasmin Level With Obesity: Some Components of Metabolic Syndrome and High-Sensitive C-Reactive Protein in Iran, Journal of Obesity (2012)
47. Can Icam and Vcam Can Predict Severity of Cad in Stable Angina?, Journal of Isfahan Medical School (2009)
48. Association Between Severity of Coronary Disease and Apolipoproteins a and B, Iranian Journal of Endocrinology and Metabolism (2011)
49. Prognostic Value of the High-Mobility Group Box-1 in Young Patients With Chest Pain, ARYA Atherosclerosis (2014)
50. A Systematic Review on the Prevalence of Metabolic Syndrome in Iranian Children and Adolescents, Journal of Research in Medical Sciences (2016)