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Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways Publisher Pubmed



Zalpoor H1, 2 ; Bakhtiyari M2, 3 ; Shapourian H4 ; Rostampour P5 ; Tavakol C6 ; Nabiafjadi M7
Authors

Source: Inflammopharmacology Published:2022


Abstract

Hesperetin, an aglycone metabolite of hesperidin with high bioavailability, recently gained attention due to its anti-COVID-19 and anti-cancer properties. Multiple studies revealed that cancer patients are prone to experience a severe form of COVID-19 and higher mortality risk. In addition, studies suggested that COVID-19 can potentially lead to cancer progression through multiple mechanisms. This study proposes that hesperetin not only can be used as an anti-COVID-19 agent but also can reduce the risk of multiple cancer progression by suppressing several intracellular signaling pathways in cancer patients with COVID-19. Therefore, in this review, we attempted to provide evidence demonstrating anti-COVID-19/cancer properties of hesperetin with several mechanisms. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.