Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways

Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways Publisher Pubmed

Zalpoor H^{1, 2} ; Bakhtiyari M^{2, 3} ; Shapourian H⁴ ; Rostampour P⁵ ; Tavakol C⁶ ; Nabiafjadi M⁷

Show Affiliations

1. Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN), Tehran, Iran
3. Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
4. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5. Department of Medical Biotechnology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
6. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Source: Inflammopharmacology Published:2022

Abstract

Hesperetin, an aglycone metabolite of hesperidin with high bioavailability, recently gained attention due to its anti-COVID-19 and anti-cancer properties. Multiple studies revealed that cancer patients are prone to experience a severe form of COVID-19 and higher mortality risk. In addition, studies suggested that COVID-19 can potentially lead to cancer progression through multiple mechanisms. This study proposes that hesperetin not only can be used as an anti-COVID-19 agent but also can reduce the risk of multiple cancer progression by suppressing several intracellular signaling pathways in cancer patients with COVID-19. Therefore, in this review, we attempted to provide evidence demonstrating anti-COVID-19/cancer properties of hesperetin with several mechanisms. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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Style	Citing Format
MLA	Zalpoor H, et al.. "Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways." Inflammopharmacology, vol. 30, no. 5, 2022, pp. 1533-1539.
APA	Zalpoor H, Bakhtiyari M, Shapourian H, Rostampour P, Tavakol C, Nabiafjadi M (2022). Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways. Inflammopharmacology, 30(5), 1533-1539.
Chicago	Zalpoor H, Bakhtiyari M, Shapourian H, Rostampour P, Tavakol C, Nabiafjadi M. "Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways." Inflammopharmacology 30, no. 5 (2022): 1533-1539.
Harvard	Zalpoor H et al. (2022) 'Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways', Inflammopharmacology, 30(5), pp. 1533-1539.
Vancouver	Zalpoor H, Bakhtiyari M, Shapourian H, Rostampour P, Tavakol C, Nabiafjadi M. Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways. Inflammopharmacology. 2022;30(5):1533-1539.
BibTex	@article{ author = {Zalpoor H and Bakhtiyari M and Shapourian H and Rostampour P and Tavakol C and Nabiafjadi M}, title = {Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways}, journal = {Inflammopharmacology}, volume = {30}, number = {5}, pages = {1533-1539}, year = {2022} }
RIS	TY - JOUR AU - Zalpoor H AU - Bakhtiyari M AU - Shapourian H AU - Rostampour P AU - Tavakol C AU - Nabiafjadi M TI - Hesperetin As an Anti-Sars-Cov-2 Agent Can Inhibit Covid-19-Associated Cancer Progression by Suppressing Intracellular Signaling Pathways JO - Inflammopharmacology VL - 30 IS - 5 SP - 1533 EP - 1539 PY - 2022 ER -

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