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Effect of Polyphenols Against Complications of Covid-19: Current Evidence and Potential Efficacy Publisher Pubmed



Vajdi M1 ; Karimi A2 ; Hassanizadeh S1 ; Farhangi MA3 ; Bagherniya M4, 5 ; Askari G4, 5 ; Roufogalis BD6, 7 ; Davies NM8 ; Sahebkar A9, 10
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  3. 3. Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Discipline of Pharmacology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia
  7. 7. NICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia
  8. 8. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, T6G 2P5, AB, Canada
  9. 9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Pharmacological Reports Published:2024


Abstract

The COVID-19 pandemic that started in 2019 and resulted in significant morbidity and mortality continues to be a significant global health challenge, characterized by inflammation, oxidative stress, and immune system dysfunction. Developing therapies for preventing or treating COVID-19 remains an important goal for pharmacology and drug development research. Polyphenols are effective against various viral infections and can be extracted and isolated from plants without losing their therapeutic potential. Researchers have developed methods for separating and isolating polyphenols from complex matrices. Polyphenols are effective in treating common viral infections, including COVID-19, and can also boost immunity. Polyphenolic-based antiviral medications can mitigate SARS-CoV-2 enzymes vital to virus replication and infection. Individual polyphenolic triterpenoids, flavonoids, anthraquinonoids, and tannins may also inhibit the SARS-CoV-2 protease. Polyphenol pharmacophore structures identified to date can explain their action and lead to the design of novel anti-COVID-19 compounds. Polyphenol-containing mixtures offer the advantages of a well-recognized safety profile with few known severe side effects. However, studies to date are limited, and further animal studies and randomized controlled trials are needed in future studies. The purpose of this study was to review and present the latest findings on the therapeutic impact of plant-derived polyphenols on COVID-19 infection and its complications. Exploring alternative approaches to traditional therapies could aid in developing novel drugs and remedies against coronavirus infection. © The Author(s) under exclusive licence to Maj Institute of Pharmacology Polish Academy of Sciences 2024.
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