Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Chemical Composition of the Essential Oil From Kelussia Odoratissima Mozaff. and the Evaluation of Its Sedative and Anxiolytic Effects in Mice Publisher Pubmed



Rabbani M1 ; Sajjadi SE1 ; Sadeghi M2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Clinics Published:2011


Abstract

OBJECTIVE: The present study aimed to evaluate the sedative and anxiolytic effects of the essential oils and hydroalcoholic extract of Kelussia odoratissima Mozaff. (K. odoratissima) in mice by utilizing an elevated plus maze. The chemical composition of its essential oil was also determined. METHODS: The hydroalcoholic extract or essential oil fraction from this plant were administered intraperitoneally to male mice at various doses 30 min before testing. The anxiolytic and sedative effects were determined by an elevated plus maze and locomotor activity tests, respectively. RESULTS: According to the results, none of the administered doses of hydroalcoholic extract or essential oil fraction of K. odoratissima changed the percentage of the time spent or number of entries into the open arms of the elevated plus maze. In contrast, the cumulative spontaneous locomotor activity of mice treated with the essential oil or hydroalcoholic extract was significantly decreased. Chemical analysis of the essential oil by Gas chromatography- mass spectromentry (GC-MS) showed that 3-butylidene-4,5-dihydrophthalide (85.9%) was the major component. CONCLUSION: These data confirm the sedative properties of K. odoratissima, yet there were no profound anxiolytic effects observed. © 2011 CLINICS.
Related Docs
View other Related Docs
1. Anti-Inflammatory Effect of Kelussia Odoratissima Mozaff. Hydroalcoholicextract on Acetic Acid- Induced Acute Colitis in Rats, Journal of Reports in Pharmaceutical Sciences (2014)
2. Hydroalcohol Extract and Fractions of Stachys Lavandulifolia Vahl: Effects on Spontaneous Motor Activity and Elevated Plus-Maze Behaviour, Phytotherapy Research (2005)
3. Phytochemical Analysis and Cytotoxicity Evaluation of Kelussia Odoratissima Mozaff., JAMS Journal of Acupuncture and Meridian Studies (2017)
4. Evaluation of Anxiolytic and Sedative Effect of Essential Oil and Hydroalcoholic Extract of Ocimum Basilicum L. and Chemical Composition of Its Essential Oil, Research in Pharmaceutical Sciences (2015)
5. Anxiolytic Effects of Stachys Lavandulifolia Vahl on the Elevated Plus-Maze Model of Anxiety in Mice, Journal of Ethnopharmacology (2003)
6. Evaluation of the Anxiolytic Effect of Nepeta Persica Boiss. in Mice, Evidence-based Complementary and Alternative Medicine (2008)
7. Isolation and Identification of Ferulic Acid From Aerial Parts of Kelussia Odoratissima Mozaff, Jundishapur Journal of Natural Pharmaceutical Products (2012)
8. Evaluation of Antianxiety and Sedative Effects of Essential Oil of Ducrosia Anethifolia in Mice, Clinics (2010)
Experts (# of related papers)
View all Related Experts
Hassan Sadraei (11)
Mohammad Rabbani (10)
Other Related Docs
9. Alleviation of Morphine Withdrawal Signs But Not Tolerance by the Essential Oil of Kelussia Odoratissima Mozaff., Evidence-based Complementary and Alternative Medicine (2012)
10. Effect of Kelussia Odoratissima Mozaffarian on Lipid and Glucose Profile, Shiraz E Medical Journal (2015)
11. Comparison of Antispasmodic Effects of Dracocephalum Kotschyi Essential Oil, Limonene and Α-Terpineol, Research in Pharmaceutical Sciences (2015)
12. Anti-Inflammatory and Analgesic Properties of Heracleum Persicum Essential Oil and Hydroalcoholic Extract in Animal Models, Journal of Ethnopharmacology (2009)
13. Antidiarrheal Action of Hydroalcoholic Extract of Pycnocycla Spinosa in Comparison With Loperamide and Dicyclomine, Iranian Journal of Pharmaceutical Research (2011)
14. Cytotoxic Evaluation of Volatile Oil From Descurainia Sophia Seeds on Mcf-7 and Hela Cell Lines, Research in Pharmaceutical Sciences (2015)
15. Antinociceptive Effect of Artemisia Dracunculus Essential Oil in Formalin Test and Possible Involvement of Serotoninergic Receptors and Nitric Oxide Pathway, Research Journal of Pharmacognosy (2024)
16. Antinociceptive Effects of Hydroalcoholic Extract and Essential Oil of Zataria Multiflora, Fitoterapia (2004)
17. Inhibitory Effect of Hydroalcoholic and Flavonoids Extracts of Dracocephalum Kotschyi, and Its Components Luteolin, Apigenin and Apigenin-4'-Galactoside on Intestinal Transit in Mice, Journal of HerbMed Pharmacology (2019)
18. Anti-Nociceptive and Anti-Inflammatory Effects of Hydroalcoholic Extract and Essential Oil of Pinus Eldarica in Animal Models, Avicenna Journal of Phytomedicine (2021)
19. Anxiolytic Effects of Salvia Reuterana Boiss. on the Elevated Plus-Maze Model of Anxiety in Mice, Journal of Ethnopharmacology (2005)
20. A Lack of Tolerance to the Anxiolytic Action of Echium Amoenum, Research in Pharmaceutical Sciences (2011)
21. Anxiolytic Effects of Lippia Citriodora in a Mouce Model of Anxiety, Research in Pharmaceutical Sciences (2018)
22. Antidiarrhoeal Assessment of Hydroalcoholic and Hexane Extracts of Dracocephalum Kotschyi Boiss. and Apigenin in Mice, Research in Pharmaceutical Sciences (2016)
23. Analgesic and Anti-Infammatory Effects of Rosa Damascena Hydroalcoholic Extract and Its Essential Oil in Animal Models, Iranian Journal of Pharmaceutical Research (2010)
24. Antimicrobial Activities and Phytochemical Composition of Echinophora Platyloba Dc. Essential Oils From Isfahan, Journal of Essential Oil-Bearing Plants (2007)
25. The Effect of Essential Oil and Hydroalcoholic Extract of Dracocephalum Kotschyi on Isolated Heart and Blood Vessel Contractions, Journal of Isfahan Medical School (2024)
26. A Possible Mechanism for the Anxiolytic-Like Effect of Gallic Acid in the Rat Elevated Plus Maze, Pharmacology Biochemistry and Behavior (2014)
27. Effects of Carum Carvi L. (Caraway) Extract and Essential Oil on Tnbs-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2013)
28. Black Cumin Seed Essential Oil, As a Potent Analgesic and Antiinflammatory Drug, Phytotherapy Research (2004)
29. Isolation and Characterization of Steroids, Phthalide and Essential Oil of the Fruits of Kelussia Odoratissima Mozaff., an Endemic Mountain Celery, Research in Pharmaceutical Sciences (2013)
30. The Effect of Dracocephalum Kotschyi Hydroalcoholic Extract on Biochemical and Hematological Parameters in Rat; [تأثیر عصارهی هیدروالکلی Kotschyi Dracocephalum روی پارامترهای بیوشیمیایی و هماتولوژیک رات], Journal of Isfahan Medical School (2022)
31. Effects of Zataria Multiflora and Carum Carvi Essential Oils and Hydroalcoholic Extracts of Passiflora Incarnata, Berberis Integerrima and Crocus Sativus on Rat Isolated Uterus, International Journal of Aromatherapy (2003)
32. Induction of Apoptosis by Essential Oil of Dracocephalum Kotschyi on Trichomonas Vaginalis, Veterinary Medicine and Science (2023)
33. Antinociceptive and Anti-Inflammatory Effects of Satureja Hortensis L. Extracts and Essential Oil, Journal of Ethnopharmacology (2002)
34. Antigenotoxic Effects of Methanolic and Aqueous Extracts of Kelussia Odoratissima Mozaffarian Against Damage Induced by Methyl Methanesulfonate, Journal of Isfahan Medical School (2013)
35. Study of Antispasmodic Action of Lavandula Angustifolia Mill Hydroalcoholic Extract on Rat Ileum, Journal of HerbMed Pharmacology (2019)
36. Phytochemical, Antioxidant and Antimicrobial Activity of the Essential Oil From Flowers and Leaves of Achillea Millefolium Subsp. Millefolium, Journal of Essential Oil-Bearing Plants (2017)
37. Antispasmodic Activity of Apigenin and Luteolin, Two Components of Dracocephalum Kotschyi Extract, on Rat Ileum Contractions, Journal of HerbMed Pharmacology (2018)
38. Volatile Constituents of Nepeta Glomerulosa Boiss. Subsp. Carmanica, Flavour and Fragrance Journal (1999)
39. Anxiolytic Effect of Flowers of Salix Aegyptiaca L. in Mouse Model of Anxiety, Journal of Complementary and Integrative Medicine (2010)
40. Anti-Spasmodic Assessment of Hydroalcoholic Extract and Essential Oil of Aerial Part of Pycnocycla Caespitosa Boiss. & Hausskn on Rat Ileum Contractions, Research in Pharmaceutical Sciences (2016)
41. Fibrinolytic Activity of Amirkabiria Odoratissima Mozaffarian, Journal of Medicinal Plants (2005)
42. Antispasmodic Effect of Dracocephalum Kotschyi Hydroalcoholic Extract on Rat Ileum Contraction, Research in Pharmaceutical Sciences (2015)
43. 3,7,10,14,15-Pentaacetyl-5-Butanoyl-13,17-Epoxy-8-Myrsinene a Novel Compound Isolated From Pycnocycla Spinosa Extract With Potent Antispasmodic and Antidiarrheal Properties, Research in Pharmaceutical Sciences (2015)