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Recent Developments in Antibody Derivatives Against Colorectal Cancer; a Review Publisher Pubmed



Ghani S1, 2, 3 ; Bahrami S2 ; Rafiee B4 ; Eyvazi S5 ; Yarian F2, 3 ; Ahangarzadeh S6 ; Khalili S7 ; Shahzamani K8 ; Jafarisani M9 ; Bandehpour M2, 3 ; Kazemi B2, 3
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Department of Medical Biotechnology, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Cellular & Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
  5. 5. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
  8. 8. Isfahan Gastroenterology and Hepatology Research Center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Clinical Biochemistry, Cancer Prevention Research Center, Shahroud university of Medical Sciences, Shahroud, Iran

Source: Life Sciences Published:2021


Abstract

Colorectal cancer (CRC) is the fourth most common cause of cancer and mortality worldwide and is the third most common cancer in men and women. Surgery, radiotherapy, and chemotherapy are conventionally used for the treatment of colorectal cancer. However, these methods are associated with various side effects on normal cells. Thus, new studies are moving towards more effective and non-invasive methods for treatment of colorectal cancer. Targeted therapy of CRC is a promising new approach to enhance the efficiency and decrease the toxicity of the treatment. In targeted therapy of CRC, antibody fragments can directly inhibit tumor cell growth and proliferation. They also can act as an ideal carrier for targeted delivery of anticancer drugs. In the present study, the structure and function of different formats of antibody fragments, immune-targeted therapy of CRC using antibody fragments will be discussed. © 2020 Elsevier Inc.
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