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Temporal Patterns of Cancer Burden in Asia, 1990–2019: A Systematic Examination for the Global Burden of Disease 2019 Study Publisher



Sharma R1 ; Abbastabar H2 ; Abdulah DM17 ; Abidi H18 ; Abolhassani H20 ; Abrehdaritafreshi Z22 ; Absalan A23, 24 ; Ali HA25 ; Abugharbieh E27 ; Acuna JM33, 34 ; Adib N35 ; Adnani QES36 ; Aghaei A37, 38 ; Ahmad A41 Show All Authors
Authors
  1. Sharma R1
  2. Abbastabar H2
  3. Abdulah DM17
  4. Abidi H18
  5. Abolhassani H20
  6. Abrehdaritafreshi Z22
  7. Absalan A23, 24
  8. Ali HA25
  9. Abugharbieh E27
  10. Acuna JM33, 34
  11. Adib N35
  12. Adnani QES36
  13. Aghaei A37, 38
  14. Ahmad A41
  15. Ahmad S43, 44
  16. Ahmadi A45
  17. Ahmadi S49
  18. Ahmed LA69
  19. Ajami M50, 72
  20. Al Hamad H73, 74
  21. Al Hasan SM75
  22. Alanezi FM77
  23. Algheethi AAS78, 79
  24. Alhanawi MK80, 81
  25. Ali A86
  26. Ali BA87, 88
  27. Alimohamadi Y89
  28. Aljunid SM99, 100
  29. Almaweri SAA101
  30. Alqahatni SA102, 103
  31. Alqudah M104, 106
  32. Alraddadi RM82
  33. Altammemi AB108, 109
  34. Ansarimoghaddam A110
  35. Anwar SL113
  36. Anwer R114
  37. Aqeel M115
  38. Arabloo J90
  39. Arabzozani M116
  40. Ariffin H118, 119
  41. Arulappan J121
  42. Ashraf T122
  43. Askari E124
  44. Athar M126, 127
  45. Atout MMW128
  46. Azadnajafabad S4
  47. Badar M129
  48. Badiye AD130
  49. Baghcheghi N131
  50. Bagherieh S133
  51. Bai R135
  52. Bajbouj K28
  53. Baliga S136
  54. Bardhan M142
  55. Bashiri A143
  56. Baskaran P150
  57. Basu S155
  58. Belgaumi UI156
  59. Bermudez ANC157, 158
  60. Bhandari B159
  61. Bhardwaj N151
  62. Bhat AN137
  63. Bitaraf S160
  64. Boloor A138
  65. Hashemi MB51
  66. Butt ZA161, 163
  67. Chadwick J164
  68. Chan JSK166
  69. Chattu VK167, 168
  70. Chaturvedi P170, 171
  71. Cho WCS172
  72. Darwesh AM26
  73. Dash NR27
  74. Dehghan A133
  75. Dhali A173
  76. Dianatinasab M174, 175
  77. Dibas M176
  78. Dixit A152
  79. Dixit SG151
  80. Dorostkar F91
  81. Dsouza HL139, 177
  82. Elbarazi I69
  83. Elemam NM29
  84. Elhuneidi W28
  85. Elkord E178, 179
  86. Elmeligy OAA83, 180
  87. Emamian MH182
  88. Erkhembayar R183
  89. Ezzeddini R184
  90. Fadoo Z187
  91. Faiz R188
  92. Fakhradiyev IR189
  93. Fallahzadeh A5, 190
  94. Faris MEM30
  95. Farrokhpour H5, 191
  96. Fatehizadeh A134
  97. Fattahi H194
  98. Fekadu G195, 197
  99. Fukumoto T198
  100. Gaidhane AM199
  101. Galehdar N124
  102. Garg P200
  103. Ghadirian F52
  104. Ghafourifard M202
  105. Ghasemi M53, 54
  106. Nour MG207
  107. Ghassemi F6
  108. Gholamalizadeh M55
  109. Gholamian A212, 213
  110. Ghotbi E56
  111. Golechha M215
  112. Goleij P216, 217
  113. Goyal S219
  114. Gubari MIM220
  115. Gunasekera DS221
  116. Gunawardane DA222
  117. Gupta S223
  118. Habibzadeh P224
  119. Boroojeni HSH57
  120. Halboub ES225, 228
  121. Hamadeh RR229
  122. Hamoudi R31, 231
  123. Harorani M233
  124. Hasanian M234
  125. Hassan TS21, 236
  126. Hay SI238, 239
  127. Heidari M46, 58
  128. Heidariforoozan M192
  129. Hessami K144, 240
  130. Hezam K242, 243
  131. Hiraike Y244
  132. Holla R249
  133. Hoseini M145, 146
  134. Hossain MM250, 251
  135. Hossain S232, 252
  136. Hsieh VCR253
  137. Huang J196
  138. Hussein NR255
  139. Hwang BF254, 256
  140. Iravanpour F147
  141. Ismail NE257, 258
  142. Iwagami M259, 260
  143. Merin LJ261
  144. Jadidiniaragh F203
  145. Jafarinia M147
  146. Jahani MA263
  147. Jahrami H230, 267
  148. Jaiswal A268
  149. Jakovljevic M270, 271
  150. Jalili M272
  151. Jamshidi E59, 274
  152. Jayarajah U275, 277
  153. Jayaram S278
  154. Jha SS279
  155. Jokar M280, 281
  156. Joseph N140
  157. Kabir A92
  158. Awal Kabir M282
  159. Kadir DH237
  160. Kakodkar PV283
  161. Kalankesh LR204
  162. Kalankesh LR204
  163. Kalhor R285, 286
  164. Kaliyadan F287
  165. Kamal VK165, 288
  166. Kamal Z289, 290
  167. Kamath A245, 249
  168. Kar SS291
  169. Karimi H5
  170. Kaur N292
  171. Keikavoosiarani L293
  172. Keykhaei M4, 7
  173. Khader YS105
  174. Khajuria H295
  175. Khan EA297
  176. Khan MN226, 299
  177. Khan M298
  178. Khan MAB70, 300
  179. Khan YH301
  180. Khanmohammadi S5, 48
  181. Khatatbeh MM303
  182. Khateri S39
  183. Khayamzadeh M68, 304
  184. Kashani HRK60
  185. Kim MS305
  186. Kompani F8
  187. Koohestani HR132
  188. Laxminarayana SLK306
  189. Krishan K307
  190. Kumar N308
  191. Kumar N308
  192. Kutluk T310
  193. Kuttikkattu A311
  194. Lai DTC312, 313
  195. Lal DK315
  196. Lami FH316
  197. Lasrado S317
  198. Lee SW318
  199. Lee SW318
  200. Lee YY320, 321, 322
  201. Leong E323
  202. Li MC324
  203. Liu J325
  204. Madadizadeh F326
  205. Mafi AR61
  206. Mahjoub S264, 265
  207. Malekzadeh R9, 148
  208. Malik AA84, 123
  209. Malik I327
  210. Mallhi TH302
  211. Mansournia MA10
  212. Martini S328, 329
  213. Mathews E330
  214. Mathur MR314, 331
  215. Meena JK269
  216. Menezes RG76
  217. Mirfakhraie R62
  218. Mirinezhad SK205
  219. Mirzaaghazadehattari M206, 332
  220. Mithra P140
  221. Mohamadkhani A9
  222. Mohammadi S5
  223. Mohammadzadeh M11
  224. Mohan S227, 334
  225. Mokdad AH238, 239
  226. Al Montasir A335, 336
  227. Montazeri F4, 63
  228. Moradi M98
  229. Sarabi MM125
  230. Moradpour F40
  231. Moradzadeh M337
  232. Moraga P340
  233. Mosapour A185, 266
  234. Motaghinejad M64
  235. Mubarik S341
  236. Muhammad JS28
  237. Murray CJL238, 239
  238. Nagarajan AJ343, 344
  239. Naghavi M238, 239
  240. Nargus S123
  241. Natto ZS85, 241
  242. Nayak BP295
  243. Nejadghaderi SA48, 63
  244. Nguyen PT345, 346
  245. Niazi RK347
  246. Noroozi N12
  247. Okatialiabad H111
  248. Okekunle AP348, 349
  249. Ong S350, 351
  250. Oommen AM352
  251. Padubidri JR354
  252. Pandey A355, 357
  253. Park EK358
  254. Park S359
  255. Pati S360
  256. Patil S169, 361
  257. Paudel R362
  258. Paudel U356, 363
  259. Pirestani M186
  260. Podder I364
  261. Pourali G208, 209
  262. Pourjafar M273
  263. Pourshams A9
  264. Syed ZQ199
  265. Radhakrishnan RA246
  266. Radhakrishnan V365
  267. Rahman M366
  268. Rahmani S4, 63
  269. Rahmanian V367
  270. Ramesh PS368
  271. Rana J369, 370
  272. Rao IR247
  273. Rao SJ371
  274. Rashedi S13, 48
  275. Rashidi MM4, 65
  276. Rezaei N3, 14
  277. Rezaei N3, 14
  278. Rezaei N3, 14
  279. Rezaei S93, 373
  280. Rezaeian M374
  281. Roshandel G338
  282. Chandan SN375
  283. Saberayad MM27, 376
  284. Sabour S48
  285. Sabzmakan L294
  286. Saddik B29
  287. Saeed U377, 378
  288. Safi SZ379, 380
  289. Sharifaskari FS32
  290. Sahebkar A210, 211
  291. Sahoo H381
  292. Sajedi SA339
  293. Sajid MR382
  294. Salehi MA15
  295. Farrokhi AS383
  296. Sarasmita MA384, 385
  297. Sargazi S112
  298. Sarode GS262
  299. Sarode SC262
  300. Sathian B73, 386
  301. Satpathy M387, 388
  302. Semwal P389
  303. Senthilkumaran S390
  304. Sepanlou SG9, 148
  305. Shafeghat M5
  306. Shahabi S149
  307. Shahbandi A15
  308. Shahrakisanavi F111
  309. Shaikh MA391
  310. Shannawaz M296
  311. Sheikhi RA47
  312. Shobeiri P16, 193
  313. Shorofi SA392, 393
  314. Shrestha S394
  315. Siabani S218, 395
  316. Singh G153, 396
  317. Singh P201
  318. Singh S154
  319. Sinha DN397, 398
  320. Siwal SS399
  321. Sreeram S248
  322. Suleman M400, 401
  323. Abdulkader RS402
  324. Sultan I107, 403
  325. Sultana A404, 405
  326. Tabish M42
  327. Tabuchi T406
  328. Taheri M66, 94
  329. Talaat IM27, 181
  330. Tehranibanihashemi A95, 96
  331. Temsah MH407
  332. Thangaraju P408
  333. Thomas N353
  334. Thomas NK409
  335. Tiyuri A97, 117
  336. Tobegai R410
  337. Toghroli R411
  338. Tovanipalone MR412, 413
  339. Ullah S414, 415
  340. Unnikrishnan B141
  341. Upadhyay E309
  342. Tahbaz SV214, 416
  343. Valizadeh R333
  344. Varthya SB154
  345. Waheed Y417, 418
  346. Wang S419
  347. Wickramasinghe DP276
  348. Wickramasinghe ND420
  349. Xiao H421, 422
  350. Yonemoto N423, 424
  351. Younis MZ425, 426
  352. Yu C341
  353. Zahir M67
  354. Zaki N71
  355. Zamanian M235
  356. Zhang ZJ342
  357. Zhao H427
  358. Zitoun OA162, 428
  359. Zoladl M19

Source: The Lancet Regional Health - Southeast Asia Published:2024


Abstract

Background: Cancers represent a challenging public health threat in Asia. This study examines the temporal patterns of incidence, mortality, disability and risk factors of 29 cancers in Asia in the last three decades. Methods: The age, sex and year-wise estimates of incidence, mortality, and disability-adjusted life years (DALYs) of 29 cancers for 49 Asian countries from 1990 through 2019 were generated as a part of the Global Burden of Disease, Injuries and Risk Factors 2019 study. Besides incidence, mortality and DALYs, we also examined the cancer burden measured in terms of DALYs and deaths attributable to risk factors, which had evidence of causation with different cancers. The development status of countries was measured using the socio-demographic index. Decomposition analysis was performed to gauge the change in cancer incidence between 1990 and 2019 due to population growth, aging and age-specific incidence rates. Findings: All cancers combined claimed an estimated 5.6 million [95% uncertainty interval, 5.1–6.0 million] lives in Asia with 9.4 million [8.6–10.2 million] incident cases and 144.7 million [132.7–156.5 million] DALYs in 2019. The age-standardized incidence rate (ASIR) of all cancers combined in Asia was 197.6/100,000 [181.0–214.4] in 2019, varying from 99.2/100,000 [76.1–126.0] in Bangladesh to 330.5/100,000 [298.5–365.8] in Cyprus. The age-standardized mortality rate (ASMR) was 120.6/100,000 [110.1–130.7] in 2019, varying 4-folds across countries from 71.0/100,000 [59.9–83.5] in Kuwait to 284.2/100,000 [229.2–352.3] in Mongolia. The age-standardized DALYs rate was 2970.5/100,000 [2722.6–3206.5] in 2019, varying from 1578.0/100,000 [1341.2–1847.0] in Kuwait to 6574.4/100,000 [5141.7–8333.0] in Mongolia. Between 1990 and 2019, deaths due to 17 of the 29 cancers either doubled or more, and 20 of the 29 cancers underwent an increase of 150% or more in terms of new cases. Tracheal, bronchus, and lung cancer (both sexes), breast cancer (among females), colon and rectum cancer (both sexes), stomach cancer (both sexes) and prostate cancer (among males) were among top-5 cancers in most Asian countries in terms of ASIR and ASMR in 2019 and cancers of liver, stomach, hodgkin lymphoma and esophageal cancer posted the most significant decreases in age-standardized rates between 1990 and 2019. Among the modifiable risk factors, smoking, alcohol use, ambient particulate matter (PM) pollution and unsafe sex remained the dominant risk factors between 1990 and 2019. Cancer DALYs due to ambient PM pollution, high body mass index and fasting plasma glucose has increased most notably between 1990 and 2019. Interpretation: With growing incidence, cancer has become more significant public health threat in Asia, demanding urgent policy attention and guidance. Its heightened risk calls for increased cancer awareness, preventive measures, affordable early-stage detection, and cost-effective therapeutics in Asia. The current study can serve as a useful resource for policymakers and researchers in Asia for devising interventions for cancer management and control. Funding: The GBD study is funded by the Bill and Melinda Gates Foundation. © 2023 The Author
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