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Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite Publisher



Baniahmad B1 ; Hassani Nadiki H2 ; Jahani S3 ; Nezamabadipour N4 ; Toolabi A5 ; Foroughi MM2
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran
  3. 3. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  4. 4. Bam University of Medical Sciences, Bam, Iran
  5. 5. Department of Environmental Health Engineering, School of Public Health, Bam University of Medical Sciences, Bam, Iran

Source: Frontiers in Chemistry Published:2022


Abstract

This study synthesized a La2O3@snowflake-like Cu2S composite to fabricate an electrochemical sensor for sensitively simultaneous detection of diclofenac and chlorzoxazone exploiting an easy hydrothermal approach, followed by analysis with XRD, FE-SEM, and EDX methods. According to voltammetric studies, the electrocatalytic diclofenac and chlorzoxazone oxidations on the electrode modified with La2O3@SF-L Cu2S composites were increased, with greater oxidation currents, as well as the oxidation potential was significantly decreased due to synergetic impact of La2O3@SF-L Cu2S composites when compared with the pure SF-L Cu2S NS-modified electrode. The differential pulse voltammetry findings showed wide straight lines (0.01–900.0 μM) for La2O3 NP@SF-L Cu2S NS-modified electrode with a limit of detection (LOD) of 1.7 and 2.3 nM for the detection of diclofenac and chlorzoxazone, respectively. In addition, the limit of quantification was calculated to be 5.7 and 7.6 nM for diclofenac and chlorzoxazone, respectively. The diffusion coefficient was calculated to be 1.16 × 10−5and 8.4 × 10−6 cm2/s for diclofenac and chlorzoxazone oxidation on the modified electrode, respectively. Our proposed electrode was examined for applicability by detecting diclofenac and chlorzoxazone in real specimens. Copyright © 2022 Baniahmad, Hassani Nadiki, Jahani, Nezamabadi-Pour, Toolabi and Foroughi.
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