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A Label-Free Electrochemical Biosensor Based on 3D Cubic Eu3+/Cu2o Nanostructures With Clover-Like Faces for the Determination of Anticancer Drug Cytarabine Publisher



Foroughi MM1 ; Jahani S2 ; Arameshbroujeni Z3 ; Rostaminasab Dolatabad M4
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Authors Affiliations
  1. 1. Department of Chemistry, Islamic Azad University, Kerman Branch, Kerman, Iran
  2. 2. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  3. 3. Department of Clinical Laboratory, AlZahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Medical Science, Islamic Azad University, Kerman Branch, Kerman, Iran

Source: RSC Advances Published:2021


Abstract

The present research utilized a simplified procedure for developing a novel electro-chemical DNA biosensor based on a carbon paste electrode (CPE) modified with three-dimensional (3D) cubic Eu3+/Cu2O nanostructures with clover-like faces (Eu3+/Cu2O CLFNs). The modified electrode was applied to monitor electro-chemical interactions between dsDNA and cytarabine for the first time. Then, the decreased oxidation signal of guanine following the interactions between cytarabine and dsDNA was utilized as an indicator for selectively determining cytarabine using differential pulse voltammetry (DPV). According to the findings, the oxidation peak current of guanine was linearly proportionate with the cytarabine concentration in the range between 0.01 and 90 μM. Additionally, the limit of quantification (LOQ) and the limit of detection (LOD) respectively equaled 9.4 nM and 2.8 nM. In addition, the repeatability, applicability and reproducibility of this analysis to drug dosage forms and human serum samples were investigated. Furthermore, UV-vis spectroscopy, DPV, docking and viscosity measurements were applied to elucidate the interaction mechanism of dsDNA with cytarabine. It was found that this DNA biosensor may be utilized to sensitively, accurately and rapidly determine cytarabine. © The Royal Society of Chemistry 2021.
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