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Covid-19 in Parkinson's Disease Treated by Drugs or Brain Stimulation; [Covid-19 En La Enfermedad De Parkinson Tratada Con Farmacos O Estimulacion Cerebral] Publisher Pubmed



Salari M1 ; Etemadifar M2 ; Zali A1, 3 ; Aminzade Z1, 4 ; Navalpotrogomez I5 ; Tehrani Fateh S1, 4
Authors
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Authors Affiliations
  1. 1. Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Functional Neurosurgery, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Chancellery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Servicio de Neurologia, Hospital del Mar-Parc de Salut Mar, IMIM, Barcelona, Spain

Source: Neurologia Published:2024


Abstract

Purpose: Covid-19 has affected all people, especially those with chronic diseases, including Parkinson's Disease (PD). Covid-19 may affect both motor and neuropsychiatric symptoms of PD patients. We intend to evaluate different aspects of Covid-19 impact on PD patients. Methods: 647 PD patients were evaluated in terms of PD-related and Covid-19-related clinical presentations in addition to past medical history during the pandemic through an online questioner. They were compared with an age-matched control group consist of 673 individuals and a sample of the normal population consist of 1215 individuals. Results: The prevalence of Covid-19 in PD patients was 11.28%. The mortality was 1.23% among PD patients. The prevalence of Covid-19 in PD patients who undergone Deep Brain Stimulation (DBS) was 18.18%. No significant association was found between the duration of disease and the prevalence of Covid-19. A statistically significant higher prevalence of Covid-19 in PD patients who had direct contact with SARS-CoV-19 infected individuals was found. No statistically significant association has been found between the worsening of motor symptoms and Covid-19. PD patients and the normal population may differ in the prevalence of some psychological disorders, including anxiety and sleeping disorders, and Covid-19 may affect the psychological status. Conclusion: PD patients possibly follow tighter preventive protocols, which lead to lower prevalence and severity of Covid-19 and its consequences in these patients. Although it seems Covid-19 does not affect motor and psychological aspects of PD as much as it was expected, more accurate evaluations are suggested in order to clarify such effects. © 2021
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