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Association Between Proton Pump Inhibitor Use and the Severity of Periodontal Disease and Peri-Implantitis: A Systematic Review Publisher Pubmed



Vedaei A1 ; Salimi Y2 ; Iranshahi Z3 ; Sadighnia N4 ; Taheri H5 ; Eyvani M2 ; Bagherianlemraski M6 ; Taheri Z7 ; Khanmohammadi MM8 ; Bina S9 ; Kavousi A7 ; Bagherihosseini S10 ; Mosaddad SA11, 12 ; Azimi N8 Show All Authors
Authors
  1. Vedaei A1
  2. Salimi Y2
  3. Iranshahi Z3
  4. Sadighnia N4
  5. Taheri H5
  6. Eyvani M2
  7. Bagherianlemraski M6
  8. Taheri Z7
  9. Khanmohammadi MM8
  10. Bina S9
  11. Kavousi A7
  12. Bagherihosseini S10
  13. Mosaddad SA11, 12
  14. Azimi N8
  15. Valipour R13
  16. Atarodi SM14
  17. Deravi N15
Show Affiliations
Authors Affiliations
  1. 1. Dental Material Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Student Research Committee, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Dental School, Kazan Federal University, Kazan, Russian Federation
  6. 6. Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada
  7. 7. Student Research Committee, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
  8. 8. Student Research Committee, Dental Branch, Islamic Azad University of Medical Sciences, Tehran, Iran
  9. 9. Department of Life Science Engineering, Faculty of New Science and Technology, Tehran, Iran
  10. 10. Student Research Committee, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
  12. 12. Department of Conservative Dentistry and Bucofacial Prosthesis, Faculty of Odontology, Complutense University of Madrid, Madrid, Spain
  13. 13. Faculty of Dentistry, Semmelweis University, Budapest, Hungary
  14. 14. School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  15. 15. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran

Source: The Journal of oral implantology Published:2024


Abstract

This systematic review investigates the probable effect of proton pump inhibitor (PPI) use on the severity of periodontal disease and peri-implantitis and implant survival. We conducted a literature search in PubMed, Scopus, and Cochrane Central Library up to April 2024. Two review authors independently screened the title and abstracts and then the full texts of retrieved studies. Observational and clinical trial studies that assessed the association between PPI use and periodontal disease severity and peri-implantitis or implant survival were included. Data extraction from the included studies was done by 2 reviewers independently. Of 940 studies initially retrieved from online searching, 7 met the inclusion criteria. Three studies examined periodontitis, whereas 4 focused on peri-implantitis and implant longevity. On the contrary, evidence regarding the impact of PPI use on peri-implantitis and implant survival is conflicting. Therefore, more well-designed randomized controlled trials are warranted to come to a definite conclusion. Because PPIs alter the gut microbiome and affect bone, plus that the pathogenesis and etiology of periodontal disease are affected by bacteria within the periodontal pocket, it is hypothesized that they may affect periodontal pathogenesis.
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