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Antibacterial Activity of Curcumin Against Periodontal Pathogens: A Systematic Review Publisher Pubmed



Fakheran O1 ; Khademi A2 ; Bagherniya M3 ; Dehghannejad M4 ; Sathyapalan T5 ; Sahebkar A6, 7, 8, 9
Authors
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Authors Affiliations
  1. 1. Dental Research Center, Department of Periodontics, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Dental Research Center, Department of Endodontics, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom
  6. 6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland
  9. 9. Halal Research Center of IRI, FDA, Tehran, Iran

Source: Advances in Experimental Medicine and Biology Published:2021


Abstract

Periodontitis is a chronic inflammatory disease characterized by destruction of the supporting structures of teeth caused by development of dental plaques and accumulation of microorganism around the gingival tissue. Curcumin has been shown to improve clinical parameters in periodontal diseases. However, the efficacy of curcumin in the elimination of periodontal pathogens is not clearly defined. The purpose of this study was to carry out a systematic review of the antibacterial activity of curcumin against periodontal pathogens. An electronic literature search in Medline, Scopus, Science Direct, Web of Science, Cochrane library, and Google scholar was performed up to February 29, 2020, to identify studies assessing the antibacterial activity of curcumin against periodontal pathogens. From 1238 publications, three clinical trials and five in vitro studies met the eligibility criteria. All three clinical studies reported improvement in restoring gingival health in clinical and microbiological parameters, following adjunctive use of curcumin for treatment of periodontitis. All five in vitro studies showed that curcumin could inhibit the growth of bacterial strains. Three of the five in vitro studies evaluated the effect of curcumin on mixed biofilm of periopathogens, which showed a significant inhibitory effect of curcumin on periodontal biofilms. This systematic review found that curcumin has antibacterial activity against periopathogens. The anti-biofilm activity of curcumin is reported as one of the mechanisms for this phenomenon. Curcumin could improve the clinical parameters of periodontal tissue not only by inhibition of the pathogens but also by modulating the host response. © 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.
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