Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Ghrelin Does Not Alter Aortic Intima-Media Thickness and Adipose Tissue Characteristics in Control and Obese Mice



Tahergorabi Z1 ; Rashidi B2 ; Khazaei M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Anatomy, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Basic Medical Sciences Published:2013

Abstract

Objective(s): Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice.Materials and Methods: This study was conducted on 24 male C57BL/6 mice. The animals were divided into four groups: control, obese (received high fat diet), control+ghrelin (injected with 100 μg/Kg subcutaneously, bid) and obese+ghrelin (n=6 each). After 10 days, animals were sacrificed and epididymal adipose tissue and thoracic aortae were removed. Adipocyte cell number, size and aortic intima-media thickness were evaluated. Results: Ghrelin did not change adipocyte cell number and size and aortic intima-media thickness in obese and control mice. In this study, high fat diet significantly decreased the number of adipocyte cells while increased their size (P<0.05). Ghrelin administration had no significant effect on adipocyte cell number and size in obese and control groups (P >0.05). In addition, it could not alter aortic intima-media thickness in both groups. Conclusion: Although ghrelin has several cardiovascular effects, it seems that it could not alter the size and number of adipocyte cells and aortic intima-media thickness in diet-induced obese mice.
Related Docs
View other Related Docs
1. Ghrelin Does Not Modulate Angiogenesis in Matrigel Plug in Normal and Diet-Induced Obese Mice, Journal of Research in Medical Sciences (2013)
2. Systemic Administration of Ghrelin Did Not Restore Angiogenesis in Hindlimb Ischemia in Control and Diet-Induced Obese Mice, Bratislava Medical Journal (2015)
3. Effect of Blockade of Neuropeptide Y Receptor on Aortic Intima-Media Thickness and Adipose Tissue Characteristics in Normal and Obese Mice, Iranian Journal of Basic Medical Sciences (2015)
4. Systemic Ghrelin Administration Alters Serum Biomarkers of Angiogenesis in Diet-Induced Obese Mice, International Journal of Peptides (2013)
5. Association of the Serum Apelin, But Not Ghrelin, With the Presence and Severity of Coronary Artery Disease, Indian Heart Journal (2021)
6. Effect of Low-Energy-Dense Diet Rich in Multiple Functional Foods on Weight-Loss Maintenance, Inflammation, and Cardiovascular Risk Factors: A Randomized Controlled Trial, Journal of the American College of Nutrition (2018)
7. Hyperinsulinemia May Have a Protective Role in the Early Stages of Atherosclerosis in Rabbit Model of Hypercholesterolemia, Journal of Diabetes and Metabolic Disorders (2012)
8. The Effect of Omega-3 on the Serum Visfatin Concentration in Patients With Type Ii Diabetes, Journal of Research in Medical Sciences (2011)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (4)
Shaghayegh Haghjooy Javanmard (4)
Other Related Docs
9. Prognostic Value of Circulating Macrophage Inhibitory Cytokine 1-Growth Differentiation Factor 15 (Mic-1/Gdf15) in Obesity: Relation With Vascular Endothelial Growth Factor (Vegf) and Markers of Oxidative Stress, Nutrition and Health (2023)
10. Effects of Chronic Scheduled–Caloric Dietary on Ghrelin Secretion and Food Intake in Adult Male Rats, Physiology and Pharmacology (Iran) (2019)
11. Visceral Obesity and Its Shared Role in Cancer and Cardiovascular Disease: A Scoping Review of the Pathophysiology and Pharmacological Treatments, International Journal of Molecular Sciences (2020)
12. Can Flaxseed Supplementation Affect Circulating Adipokines in Adults? an Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, Frontiers in Nutrition (2023)
13. Protective and Curative Effects of Unconjugated Bilirubin on Gene Expression of Lox-1 and Inos in the Heart of Rats Receiving High-Fat Diet and Low Dose Streptozotocin: A Histomorphometric Approach, Journal of Inflammation (United Kingdom) (2024)
14. Correlation of Circulating Inflammatory Markers, Ghrelin, Adiponectin With Obesity Indices in Subjects With Metabolic Syndrome, Pakistan Journal of Medical Sciences (2013)
15. Evaluation of Fat Cell's Size, Number and Their Mediators in Ischemic Heart Disease Patients, Journal of Isfahan Medical School (2010)
16. Association of Serum Ceruloplasmin Level With Obesity: Some Components of Metabolic Syndrome and High-Sensitive C-Reactive Protein in Iran, Journal of Obesity (2012)
17. The Effect of L-Arginine on Serum Lipids and Nitrite Levels, and the Number of Apoptotic Cells, Inos and Enos Expressions of Aorta After the Formation of Fatty Streaks in Rabbit, Journal of Applied Biomedicine (2008)
18. Von Willebrand Factor, C-Reactive Protein, Nitric Oxide, and Vascular Endothelial Growth Factor in a Dietary Reversal Model of Hypercholesterolemia in Rabbit., Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia (2008)
19. Effect of Chronic L-Arginine Supplementation on Aortic Fatty Streak Formation and Serum Nitric Oxide Concentration in Normal and High-Cholesterol Fed Rabbits, Acta Physiologica Hungarica (2012)
20. Obesity and Inflammation: Role of Adipokines, Journal of Isfahan Medical School (2016)
21. Effects of Dietary Patterns, Weight Loss Diets, and Dietary Components on Serum Adiponectin Levels, Journal of Isfahan Medical School (2012)
22. The Effects of Omega-3 on Blood Pressure and the Relationship Between Serum Visfatin Level and Blood Pressure in Patients With Type Ii Diabetes, ARYA Atherosclerosis (2012)
23. Association Between Adipokine and Myeloperoxidase Levels in Patients With Coronary Artery Disease, Acta Medica Iranica (2015)
24. Correlations Between Serum Leptin and Nitric Oxide Concentrations in Obese and Control Balb/C Mice, Journal of Isfahan Medical School (2013)
25. Alpha-Lipoic Acid Effect on Leptin and Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, European Journal of Clinical Pharmacology (2020)
26. Short- and Long-Term Relationships of Serum Ghrelin With Changes in Body Composition and the Metabolic Syndrome in Prepubescent Obese Children Following Two Different Weight Loss Programmes, Clinical Endocrinology (2008)
27. Effects of Dietary Supplementation With Ghee, Hydrogenated Oil, or Olive Oil on Lipid Profile and Fatty Streak Formation in Rabbits, ARYA Atherosclerosis (2012)
28. Comparative Effects of Carbohydrate Versus Fat Restriction on Serum Levels of Adipocytokines, Markers of Inflammation, and Endothelial Function Among Women With the Metabolic Syndrome: A Randomized Cross-Over Clinical Trial, Annals of Nutrition and Metabolism (2013)
29. Lipid Profiles and Serum Visfatin Concentrations in Patients With Type Ii Diabetes in Comparison With Healthy Controls, International Journal of Preventive Medicine (2012)
30. Fatty Acid Composition of Epicardial and Subcutaneous Human Adipose Tissue, Metabolic Syndrome and Related Disorders (2009)
31. Effect of Substituting Saturated With Monounsaturated Fatty Acids on Serum Visfatin Levels and Insulin Resistance in Overweight Women: A Randomized Cross-Over Clinical Trial, International Journal of Food Sciences and Nutrition (2012)
32. The Dietary Inflammatory Index Is Positively Associated With Cardiometabolic Risk Parameters in Atherosclerosis Patients, Nutrition Research (2022)
33. The Effect of Moderate Substitution of Dietary Carbohydrates by Fats on Serum Levels of Adipocytokines, Inflammatory Indices, and Biomarkers of Endothelial Function Amongwomen With Metabolic Syndrome, Journal of Zanjan University of Medical Sciences and Health Services (2012)
34. Vitamin C Protects Against Chronic Social Isolation Stress-Induced Weight Gain and Depressive-Like Behavior in Adult Male Rats, Endocrine Regulations (2020)
35. Association of Changes in Oxidative and Proinflammatory States With Changes in Vascular Function After a Lifestyle Modification Trial Among Obese Children, Clinical Chemistry (2008)
36. The Relationship Between Inflammatory Markers, Angiogenesis, and Obesity, ARYA Atherosclerosis (2013)