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Application of Chitosan/Pva Nano Fiber As a Potential Wound Dressing for Streptozotocin-Induced Diabetic Rats Publisher Pubmed



Ahmadi Majd S1 ; Rabbani Khorasgani M1 ; Moshtaghian SJ1 ; Talebi A2 ; Khezri M1
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Authors Affiliations
  1. 1. University of Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Biological Macromolecules Published:2016


Abstract

Diabetes mellitus is a worldwide health problem affecting 1–2% of the population of world with noticeable morbidity and mortality. Vascular events such as hypertension, nephropathy, neuropathy and retinopathy are happened in diabetic patients. Decline in tissue blood circulation may causes hypoxia and finally may leads to slow wound healing and amputation. PVA/Chitosan Nano fiber wound dressings have high moisture vapor transmission rate and good antimicrobial activity1 PCNWD substrate does not have any recognized cytotoxicity effects and has excellent odor absorbing capability. In the present study, Streptozotocin (STZ) is used to induce diabetes in rats, Skin ulcers are produced experimentally in the experimentally induced diabetic and non-diabetic rats. Then PCNWD used as wound dressing for 2 weeks period to evaluate its macroscopic and microscopic effects on wound healing in comparison with untreated diabetic and non-diabetic rats experimental ulcers. The findings of current study indicate significant acceleration in diabetes wound healing on the rats treated by PVA/Chitosan Nano fiber. © 2016 Elsevier B.V.
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