Assessment of Gated Single Photon Emission Computerized Tomography Cardiac Wall Motion by Using Different Reconstruction Methods and Filters in Comparison With Quantitative Coronary Angiography Publisher



Shahbazigahrouei D¹ ; Arabpour A¹ ; Kermani S¹ ; Rastgoo F² Show Affiliations
Source: Journal of Medical Sciences Published:2008

Abstract

The aim of this study was to check which of reconstruction (FBP and OSEM) methods and which of (Butterworth, Metz and Ramp) filters with which frequency and order for filtration manner in ECG Gated SPECT (single photon emission computerized tomography) is more coincident with Wall Motion in quantitative coronary angiography methods. In this study, cardiac wall motion of 25 patients (16 males, 9 females, mean ages, 54.08 y) who had an angiography five days before the scanning refened for evaluation of coronary artery disease underwent 99 mTc-tetrofosmin gated SPECT in comparison with quantitative coronary angiography. LV ejection fraction (LVEF), end-systolic volume (ESV) and end-diastolic volume (EDV) from EGS were compared with QCA. Then quantitative regional wall motion was assessed in these patients with both methods. The sampling is continuous and the study was experimental. Motion disorders are classified in four categories: normal = 0, mild = 1, moderate = 2 and severe = 3. For defining the cardiac wall motion, using FBP and OSEM methods in ECG Gated SPECT and by changing the frequency cut-off and order in Butterworth, Metz and ramp filters, found 42 different states that checked them with quantitative coronary angiography findings. LV end-diastolic, LV end-systolic volumes and LV ejection fraction were analyzed with dedicated software. Correlations were excellent between QCA and EGS (r∼0.8). FBP with ramp filter before the reconstruction, with Metz filter and Order = 9 and FWHM = 5 after the construction in Gated SPECT method have a coincidence with quantitative coronary angiography. By using both physical methods, reconstruction and filtration in Gated SPECT and comparing the cardiac wall motion parameters in Gated SPECT with quantitative coronary angiography, usage of non-invasive Gated SPECT method instead of invasive coronary angiography in some cases is recommended. EGS was in proper agreement with QCA for quantification of cardiac WM. Global and regional LV function and LV volumes can be adequately assessed with EGS. EGS has a robust evidence base, including the support of numerous clinical guidelines and is considered a clinically acceptable method to evaluate cardiac wall motion. Gated SPECT studies allow simultaneous assessment of perfusion and function in a single-injection, single-acquisition sequence.