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Association of Cardiac Autonomic Neuropathy With Arterial Stiffness in Type 2 Diabetes Mellitus Patients Publisher



Bagherzadeh A1 ; Nejatiafkham A2 ; Tajallizadekhoob Y3 ; Shafiee A4 ; Sharifi F3 ; Esfahani MA5 ; Badamchizade Z3 ; Alatab S3 ; Fakhrzadeh H3, 6
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Cardiology and Cardiac Electrophysiology, Dr Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cardiology, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Elderly Health Research Center, Endocrinology and Metabolism population Sciences Institute, Tehran University of Medical Sciences, Dr Shariati Hospital, North Karegar Avenue, 5th floor, Tehran, 1411413137, Iran
  4. 4. Department of Cardiovascular Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Cardiology Department, St alzahr hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2013


Abstract

Background: Diabetic patients are at the risk of cardiac autonomic neuropathy (CAN) and arterial stiffness. This study aimed to investigate the association of heart rate variability (HRV) as an index for CAN and pulse wave velocity (PWV) as an index for arterial stiffness.Methods: Uncomplicated diabetes type-2 patients who had no apparent history of cardiovascular condition underwent HRV and PWV measurements and the results were compared with the control group consisting of non-diabetic peers. Also, the findings were adjusted for the cardiovascular risk factors and other confounding factors.Results: A total of 64 diabetic patients (age= 52.08±8.50 years; males=33 [51.6%]) were compared with 57 controls (age= 48.74±6.18 years; males=25 [43.9%]) in this study. Hypertension, dyslipidemia, and thereby systolic blood pressure and statin use were significantly more frequent in the diabetic group, while the serum levels of cholesterol, HDL-C and LDL-C were significantly higher in the controls. Pulse wave was significantly increased in the diabetic patients (p<0.001). Main HRV parameters were significantly lower in diabetics than in controls. After adjustment for the confounders, PWV and HRV remained significantly different between the groups (p=0.01 and p=0.004, respectively). Multiple logistic regression of the association between pulse wave velocity and HRV index was independently significant both in diabetics and controls.Conclusions: There exists a significant relationship between heart rate variability and arterial stiffness as a measure for atherosclerosis in diabetic patients, although the role of the confounding factors is noteworthy. © 2013 Bagherzadeh et al.; licensee BioMed Central Ltd.
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