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The Effectiveness of Phytosomal Curcumin on Inflammation in Patients With Multiple Trauma Admitted to the Intensive Care Unit: A Double-Blind Randomized Placebo-Controlled Trial; [بررسی اثر مکمل کورکومین فیتوزومال بر التهاب در بیماران مولتیپل ترومای بستری در بخشمراقبتهای ویژه] Publisher

Summary: New study finds phytosomal curcumin reduces CRP levels in ICU patients with multiple traumas, potentially improving outcomes. #CurcuminResearch #TraumaCare

Abbasi S1 ; Mirjalili M1 ; Alikiaii B1 ; Bagherniya M2
Authors
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Authors Affiliations
  1. 1. Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2025


Abstract

Background: Multiple trauma has serious complications, which increases the risk of morbidity and mortality in the patients. This study aimed to evaluate the impact of supplementation with phytosomal curcumin on CRP in critically ill patients with multiple traumas. Methods: In this double-blind trial, 53 patients with multiple trauma who were admitted to the intensive care unit (ICU) were randomized to receive either two capsules, each capsule containing 250 mg phytosomal (a total of 500 mg daily) as an intervention group or two identical capsules (placebo capsules), each containing 250 mg maltodextrin for 7 days. Clinical and laboratory parameters were assessed before and after the intervention. Findings: After seven days of intervention, quantitative C-reactive protein (CRP) (P = 0.044) levels significantly decreased in the curcumin compared with the placebo group. Conclusion: Phytosomal curcumin had a beneficial effect on laboratory factor (CRP) in ICU-admitted patients with multiple trauma. © 2025 Isfahan University of Medical Sciences(IUMS). All rights reserved.
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