Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Combination Therapy With Hydrocortisone+ Ascorbic Acid+ Neurobion on the Prognosis of Multiple Trauma Patients; [تأثیر درمان ترکیبی با هیدروکورتیزون+آسکوربیک اسید+ نوروبیون در پیش آگهی بیماران مالتیپل تروما] Publisher



Hashemi ST1 ; Abbasi S1 ; Masoudpour A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2023


Abstract

Background: Inflammatory responses are one the factors influencing the prognosis of multiple trauma patients. Hydrocortisone, with an appropriate dose, diminishes the inflammatory responses without immunosuppression, improving the patients’ immune system. Administering vitamins specifically vitamin B and C to multiple trauma patients, by eliminating free radicals, could decrease the mortality of these patients. This study was done to evaluate the efficacy of treatment with a combination of Hydrocortisone+ Ascorbic acid+ Neurobion (vitB1+B6+B12) on the prognosis of multiple trauma patients hospitalized in Intensive Care Units. Methods: In a three-blind clinical trial study, 60 multiple trauma patients randomly allocated to two groups of intervention and control. In the intervention group, the patients received 1.5g vitamin C every 6 hours for a period of 4 days, Hydrocortisone 50 mg every 6 hours for a period of 7 days, two Neurobion every 12 hours for 4 days. In the control group, the patients received placebo. The patients in both groups were followed for ninety days and eventually, length of ICU stay, the need for mechanical ventilation and duration of mechanical ventilation were determined and compared between the two groups. Findings: The mean duration of mechanical ventilation in the intervention and control group were 8.96 ± 6.03 and 14.8 ± 8.11 respectively which was statistically significant. There were no significant differences between the two groups in other outcome measures. Conclusion: Our study shows administration of combination of Hydrocortisone+ Ascorbic acid+ Neurobion (vitB1+B6+B12) could decrease the duration of mechanical ventilation in multiple trauma patients. © 2023 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Is It Time to Reconsider the Administration Of Thiamine Alone or in Combination With Vitamin C in Critically Ill Patients? a Meta-Analysis of Clinical Trial Studies, Journal of Intensive Care (2022)
2. The Effect of Low Dietary Inflammatory Index Score Formula on Inflammatory, Metabolic, and Clinical Outcomes in Critically Ill Traumatic Brain Injury Patients: A Single-Blind Randomized Controlled Pilot Study, Food Science and Nutrition (2023)
3. The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients With Severe Sepsis: A Randomized Control Clinical Trial Study, Journal of Isfahan Medical School (2022)
4. The Effects of L-Carnitine Supplementation on Inflammatory Markers, Clinical Status, and 28 Days Mortality in Critically Ill Patients: A Double-Blind, Randomized, Placebo-Controlled Trial, Clinical Nutrition ESPEN (2022)
5. Reactive Oxygen Metabolites and Anti-Oxidative Defenses in Aspirin-Induced Gastric Damage in Rats: Gastroprotection by Vitamin E, Pathophysiology (2006)
6. The Role of Cobalamin in Multiple Sclerosis: An Update, Inflammation (2024)
7. Potential Immune Indicators for Predicting the Prognosis of Covid-19 and Trauma: Similarities and Disparities, Frontiers in Immunology (2022)
8. Effects of Progesterone and Vitamin D on Outcome of Patients With Acute Traumatic Spinal Cord Injury; a Randomized, Double-Blind, Placebo Controlled Study, Journal of Spinal Cord Medicine (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Bagherniya (8)
Babak Alikiaii (6)
Other Related Docs
9. Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats, International Journal of Preventive Medicine (2024)
10. The Effects of L-Carnitine Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Critically Ill Patients With Sepsis: A Randomized, Double-Blind, Controlled Trial, Nutrition Journal (2024)
11. Evaluation of Curcumin-Piperine Supplementation in Covid-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial, Advances in Experimental Medicine and Biology (2023)
12. The Effect of Vitamin D Supplement on Outcomes in Patients With Traumatic Injuries Hospitalized in Intensive Care Unit: A Clinical Trial Study, Journal of Isfahan Medical School (2020)
13. Preventive Use of Ascorbic Acid for Atrial Fibrillation After Coronary Artery Bypass Graft Surgery, Heart Surgery Forum (2018)
14. The Relationship Between Vitamin D, Clinical Outcomes and Mortality Rate in Icu Patients: A Prospective Observational Study, Journal of Research in Medical Sciences (2016)
15. Deficient Vitamin B12 Levels Are Associated With Increased Delirium Incidence in Critically Ill Patients, Clinical Nutrition ESPEN (2023)
16. The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study, Immunity, Inflammation and Disease (2023)
17. Low Plasma Vitamin D Is Associated With Increased 28-Day Mortality and Worse Clinical Outcomes in Critically Ill Patients, BMC Nutrition (2024)
18. The Effectiveness of Phytosomal Curcumin on Clinical and Laboratory Parameters of Patients With Multiple Trauma Admitted to the Intensive Care Unit: A Double-Blind Randomized Placebo-Controlled Trial, BMC Complementary Medicine and Therapies (2024)
19. The Effectiveness of Phytosomal Curcumin on Inflammation in Patients With Multiple Trauma Admitted to the Intensive Care Unit: A Double-Blind Randomized Placebo-Controlled Trial; [بررسی اثر مکمل کورکومین فیتوزومال بر التهاب در بیماران مولتیپل ترومای بستری در بخشمراقبتهای ویژه], Journal of Isfahan Medical School (2025)
20. The Effects of L-Carnitine Supplementation on Inflammatory Factors, Oxidative Stress, and Clinical Outcomes in Patients With Sepsis Admitted to the Intensive Care Unit (Icu): Study Protocol for a Double Blind, Randomized, Placebo-Controlled Clinical Trial, Trials (2022)
21. The Effect of Boswellia Serrata on Neurorecovery Following Diffuse Axonal Injury, Brain Injury (2013)
22. Serum Procalcitonin Levels of Patients With Candidemia Hospitalized in Intensive Care Units, Journal of Medical Sciences (Taiwan) (2018)