Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparison of the Effects of Morphine and Diltiazem on Blood Pressure and Heart Rate During Craniotomy Surgeries



Attari M1 ; Talakoub R1 ; Rahimzadeh B2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Anesthesiology and Critical Care Research center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2016

Abstract

Background: Getting out of the anesthesia occurs with stimulation of sympathetic system and increasing in patient's pulse and blood pressure. Various methods are used to control the blood pressure and heart rate, but there is no single method, so far. This study aimed to compare the effects of morphine and diltiazem of blood pressure and pulse rate in recovery time among the patients underwent craniotomy. Methods: In a double-blind clinical trial study during 2012-2013, 60 patients who were candidates for craniotomy were selected and divided in two groups of 30. The first group received 60 mg diltiazem and the second group received 0.1 mg/kg morphine. During 4 hours after the surgery, the hemodynamic variables were checked and compared between the two groups. Findings: Before the operation, the mean systolic blood pressure was 120.6 ± 12.5 and 126.8 ± 18.7 mmHg in morphine and diltiazem groups, respectively (P = 0.560). 4 hours after the drug consumption, mean systolic blood pressure was 130.6 ± 13.2 and 100.4 ± 16.2 mmHg in morphine and diltiazem groups, respectively (P < 0.001). During the follow-up period in recovery room, there was no significant difference between the blood pressure and heart rate between the two groups; but 4 hours after the drug consumption, systolic and diastolic blood pressure was significantly lower in the diltiazem group. During the study, there was no significant difference in heart rates between the two groups. Conclusion: According to the results of the study, using diltiazem led to better control of blood pressure during craniotomy with little side effects. So, it can be used safely in patients under craniotomy. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Comparative Study of the Effect of Two Different Doses of Remifentanil on Bleeding Control in Lumbar Fusion Surgery: A Randomized Clinical Trial, Annals of Medicine and Surgery (2022)
2. Comparison of the Hemodynamic Indices During Skull-Pin Head-Holder Insertion in Neurosurgeries in Two Groups Receiving Dexmedetomidine and Midazolam, Journal of Isfahan Medical School (2021)
3. The Effect of Intravenous Midazolam on Duration of Spinal Anesthesia, Shiraz E Medical Journal (2015)
4. Comparing 'Remifentanil-Propofol' and 'Fentanyl-Propofol' in Patients Undergoing Craniotomy for Supratentorial Space-Occupying Lesions, Tehran University Medical Journal (2012)
5. Comparision of Hemodynamic Changes, Movement, Duration of Surgery and Pain Between Lateral and Supine Posision After Spinal Anesthesia in Transurethral Lithotrips, Journal of Renal Injury Prevention (2019)
6. The Comparison of the Efficacy and Safety of Sedation With Etomidate- Fentanyl Versus Ketamine-Midazolam Combinations in Cataract Surgery, Journal of Isfahan Medical School (2012)
7. Premedication With Oral Dextromethorphan Reduces Intra-Operative Morphine Requirement, Journal of Research in Medical Sciences (2005)
8. Cotimparave Evaluation of Oral Alprazolam, As Premedication, on Controlling Blood Pressure in Hypertensive Patients During Surgery, Journal of Isfahan Medical School (2015)
Experts (# of related papers)
View all Related Experts
Azim Honarmand (23)
Mohammad Reza Safavi (19)
Other Related Docs
9. A Comparison of Sedation Quality With Midazolam-Ketamine Versus Propofol-Ketamine During Phacoemulsification Surgery, Tehran University Medical Journal (2021)
10. The Effect of Tranexamic Acid and Controlled Hypotension on Perioperative Blood Loss in Craniosynostosis Surgery, Anesthesiology and Pain Medicine (2023)
11. Comparison the Effects of Etomidate Infusion Versus Ketamine-Midazolam-Fentanyl Combination in Sedation for Cataract Surgery, Journal of Isfahan Medical School (2013)
12. Evaluating the Effect of Adding Furosemide to Hypertonic Saline 5% on the Intracranial Pressure in Candidates of Craniotomy for Resection of Supratentorial Brain Tumors, Journal of Isfahan Medical School (2018)
13. The Comparison of the Effects of Fentanyl and Dexmedetomidine on Hemodynamic Stability in Patients Undergoing Stereotactic Surgery, Journal of Isfahan Medical School (2022)
14. Comparison of the Effect of Thiopental Sodium Supplementation and Hypertonic Saline 5% Alone or Their Combination on Intracranial Pressure Changes During Craniotomy Surgeries, Journal of Isfahan Medical School (2019)
15. The Effect of Labetalol or Remifentanil on Blood Pressure and Heart Rate After Laryngoscopy and Intubation, Journal of Isfahan Medical School (2017)
16. Comparison of the Efficacy of Midazolam and Dexmedetomidine in Quality of Sedation in Mechanically-Ventilated Patients Admitted to Intensive Care Unit, Journal of Isfahan Medical School (2018)
17. Bispectral Index Response to Cricoid Pressure During Induction of General Anesthesia, Journal of Research in Medical Sciences (2011)
18. Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia, Journal of Ophthalmic and Vision Research (2011)
19. A Comparison of Bispectral Index Between Spinal and Epidural Anesthesia During Cesarean Section, Journal of Isfahan Medical School (2012)
20. Effect of Intravenous Infusion of Lidocaine on Pain Reduction After Cesarean Section Under General Anesthesia, Journal of Cellular and Molecular Anesthesia (2018)
21. Attenuation of Cardiovascular Responses to Laryngoscopy and Tracheal Intubation-Intravenous Sufentanil Vs Pethidine, Middle East Journal of Anesthesiology (2008)
22. Postoperative Residual Block in Postanesthesia Care Unit More Than Two Hours After the Administration of a Single Intubating Dose of Atracurium, Journal of Research in Medical Sciences (2011)
23. Comparative Evaluation of Bispectral Index System After Sedation With Midazolam and Propofol Combined With Remifentanil Versus Ketamine in Uncooperative During Dental Procedures, Dental Research Journal (2016)
24. Clinical Trial of Nitroglycerin-Induced Controlled Hypotension With or Without Acupoint Electrical Stimulation in Microscopic Middle Ear Surgery Under General Anesthesia With Halothane, Acta Anaesthesiologica Taiwanica (2005)
25. The Efficacy of Prophylactic Intravenous Aminophylline, Paracetamol or Aminophylline and Paracetamol in Prevention of Post Spinal Headache in Lower Extremity Surgeries Compared to the Control Group, Tehran University Medical Journal (2019)
26. The Effect of Early Ambulation on the Incidence of Neurological Complication After Spinal Anesthesia With Lidocaine, Journal of Research in Medical Sciences (2015)
27. The Effect of Intravenous Therapy With Hypertonic Saline 5% (Hts) in Patients With High Intracranial Pressure, 24 and 48 Hours After the Surgery, Journal of Isfahan Medical School (2016)
28. Comparative Study of the Effect of Two Different Doses of Intravenous Labetalol on the Cardiovascular Response to Endotracheal Extubation, Journal of Cardiovascular and Thoracic Research (2023)
29. Comparison of Dexmedetomidine Versus Midazolam on Hemodynamic Parameters, Bleeding, Satisfaction of Surgeons and Patients Who Underwent Laminectomy Surgery by Spinal Anesthesia, Tehran University Medical Journal (2021)
30. Comparing the Effects of Ketamine Alone and in Combination With Metoclopramide on Postoperative Pain, Journal of Isfahan Medical School (2013)
31. Oral Clonidine Premedication Decreases Intraoperative Bleeding in Patients Undergoing Endoscopic Sinus Surgery, Journal of Research in Medical Sciences (2005)
32. Comparison of the Effect of Hematoma Block and Injection of Lidocaine With and Without Ketamine on Reduction of Pain in Patients With Distal Radius Fracture, Journal of Isfahan Medical School (2021)
33. Postoperative Analgesia After Caesarean Section: Intermittent Intramuscular Versus Subcutaneous Morphine Boluses, Acute Pain (2007)
34. Comparing an Endoscopy-Guided Removal Method of Nontrumatic Intracerebral Hemorrhage With Open Craniotomy, Journal of Isfahan Medical School (2011)
35. Effects of the Two Doses of Dexmedetomidine on Sedation, Agitation, and Bleeding During Pediatric Adenotonsillectomy, Anesthesiology and Pain Medicine (2021)
36. Mini-Dose Bier's Block Vs Systemic Analgesia in Distal Radius Fractures: A Promising Reduction in Emergency Department Throughput Time, Pain Management (2023)
37. Comparison of the Effect of Adding Ketamine to Sodium Thiopental and Propofol on the Quality of Sedation in Cataract Surgery With Phacoemulsification Under Local Anesthesia and Intravenous Sedation; [مقایسه‌ی اثر افزودن کتامین به سدیم تیوپنتال و پروپوفول بر کیفیت آرام‌بخشی در جراحی آب مروارید با فیکوامولسیفیکاسیون تحت بی‌حسی موضعی و آرام‌بخشی داخل وریدی], Journal of Isfahan Medical School (2024)
38. Comparing the Effects of Magnesium Sulfate and Nitroglycerin on the Control of Hypertension During and After Cataract Surgery Under Local Anesthesia and Intravenous Sedation, Journal of Isfahan Medical School (2016)
39. Supplementing Epidural Lidocaine With Midazolam: Effect on Sensorymotor Block Level, Acta Anaesthesiologica Taiwanica (2004)
40. Outcome of Decompressive Craniectomy in Patients With Severe Head Injury: A Pilot Randomized Clinical Trial, Neurosurgery Quarterly (2012)
41. Attenuation of the Pressor Response to Direct Laryngoscopy and Tracheal Intubation: Oral Clonidine Vs. Oral Gabapentin Premedication, Journal of Research in Medical Sciences (2011)
42. Effect of Low-Dose Ketamine Versus Lidocaine on Hemodynamic Response to Endotracheal Intubation in General Anesthesia: A Prospective, Triple-Blinded, Randomized Controlled Trial, Tehran University Medical Journal (2023)
43. Effects of Lidocaine on Reducing the Need for Anesthetic Drugs During Ophthalmologic Surgeries, Journal of Isfahan Medical School (2013)
44. Comparison of Success Rate and Onset Time of Two Different Anesthesia Techniques, Medicina Oral, Patologia Oral y Cirugia Bucal (2015)
45. The Comparison of Spinal Anesthesia With General Anesthesia on the Postoperative Pain Scores and Analgesic Requirements After Elective Lower Abdominal Surgery: A Randomized, Double-Blinded Study, Journal of Research in Medical Sciences (2013)
46. Comparison of the Effect of Two Doses of Remifentanil Infusion on the Amount of Bleeding, Intraoperative Hemodynamic Changes and Complications After Rhinoplasty Surgery With General Anesthesia; [مقایسه تاثير انفوزیون دو دوز رميفنتانيل بر ميزان خونریزی، تغييرات همودیناميک حين عمل و عوارض پساز عمل جراحی رینوپلاستی پساز بيهوشی عمومی], Tehran University Medical Journal (2023)
47. Evaluation of the Efficacy of the Valsalva Maneuver and Fentanyl Administration for Attenuating Etomidate Injection Pain: A Double-Blind Clinical Trial, Journal of Emergency Practice and Trauma (2024)
48. Comparison of the Sedation Quality of Etomidate, Propofol, and Midazolam in Combination With Fentanyl During Phacoemulsification Cataract Surgery: A Double-Blind, Randomized, Controlled, Clinical Trial, Anesthesiology and Pain Medicine (2019)
49. The Effect of Intranasal Administration of Remifentanil at Different Doses on Electroconvulsive Therapy-Induced Hemodynamic Changes in Adults, Journal of Kerman University of Medical Sciences (2025)
50. Bispectral Index Values During Spinal Anesthesia Using Hyperbaric Bupivacaine With Intrathecal or Intravenous Fentanyl for Cesarean Section, Journal of Research in Medical Sciences (2012)