Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Comparison of the Effects of Fentanyl and Dexmedetomidine on Hemodynamic Stability in Patients Undergoing Stereotactic Surgery Publisher



Masoudifar M1 ; Foroughi M2 ; Hashemi T1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2022


Abstract

Background: In patients undergoing surgery, hemodynamic disorders are common. Therefore, we decided to compare the effects of fentanyl and dexmedetomidine on hemodynamic changes in patients undergoing Stereotactic surgery. Methods: In this double blinded clinical trial, 68 candidates for Stereotactic Surgery in Alzahra Hospital in 2017 enrolled in the study. Patients were randomly divided into two groups; the first group was given bolus of 2 μg / kg fentanyl, and in the second group a loading dose of 1 μgr / kg / 10 min, followed by maintenance dose of: 0.5 μg / kg / h of dexmedetomidine was admininstered intravenously. The Dexmedetomidine was infused immediately following anesthesia induction. The hemodynamic variables in the two groups were evaluated. Findings: There was no significant difference between the two groups based on systolic and diastolic blood pressure and oxygen saturation at different times. The heart rate in the dexmedetomidine group at 30, 60 and 90 minutes was significantly lower than fentanyl. On the other hand, there was no significant difference between the two groups with regards to pH, Pco2 and HCO3 before and after operation and recovery time. Conclusion: Both dexmedetomidine and fentanyl are two effective drugs for controlling hemodynamics parameters in patients undergoing stereotactic surgery, but dexmedetomidine drug reduces heart rate significantly compared with fentanyl. © 2022 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Oral Clonidine Premedication Decreases Intraoperative Bleeding in Patients Undergoing Endoscopic Sinus Surgery, Journal of Research in Medical Sciences (2005)
2. The Effect of Remifentanil on Hemodynamic Response to Laryngeal Mask Airway Insertion in Induction of Anesthesia With Propofol Fentanyl or Propofol Ketamine in Cataract Surgery, Medical Journal of Tabriz University of Medical Sciences (2022)
3. Assessing the Effects of Dexmedetomidine and Labetalol on Changes in Heart Rate and Blood Pressure After Laryngoscopy Compared to a Control Group, Journal of Cellular and Molecular Anesthesia (2020)
4. The Effect of Dexmedetomidine Infusion Vs. Morphine on Duration of Mechanical Ventilation in Cabg: A Clinical Trial, Journal of Cellular and Molecular Anesthesia (2021)
5. Comparing the Hemodynamic Effects of Nebulized Dexmedetomidine and Nebulized Lidocaine in Children Undergoing Fiberoptic Bronchoscopy, Journal of Advances in Medical and Biomedical Research (2019)
6. Efficacy of Two Doses of Dexmedetomidine on Attenuating Cardiovascular Response and Safety of Respiratory Tract to Extubation, Journal of Cardiovascular and Thoracic Research (2023)
7. Effect of Sufentanil Plus Propofol Versus Fentanyl Plus Propofol on the Cardiovascular Response to Laryngoscopy and Endotracheal Intubation; [تأثیر فنتانیل و سوفنتانیل در ترکیب با پروپوفول بر تغییرات ضربان قلب و فشارخون بعد از لارنگوسکوپی و لولهگذاری تراشه], Journal of Isfahan Medical School (2025)
8. The Effect of Adding Dexmedetomidine to Fentanyl for Pain Management After Spinal Fusion Surgery Using Intravenous Patient-Controlled Analgesia Pumps; a Clinical Trial Study, Journal of Isfahan Medical School (2017)
Experts (# of related papers)
View all Related Experts
Azim Honarmand (33)
Mohammad Reza Safavi (29)
Other Related Docs
9. Comparison of the Hemodynamic Indices During Skull-Pin Head-Holder Insertion in Neurosurgeries in Two Groups Receiving Dexmedetomidine and Midazolam, Journal of Isfahan Medical School (2021)
10. A Comparison of Sedative Effect of Dexmedetomidine-Fentanyl Versus Midazolam-Fentanyl During Cataract Surgery With Phacoemulsification Technique, Journal of Isfahan Medical School (2018)
11. Comparison of the Efficacy of Two-Drug Combination, Ketofol and Fenofol, on Sedation and Analgesia in Patients Under the Surgery of Port Catheter Placement and Removal, Journal of Isfahan Medical School (2019)
12. Comparison of the Premedication Effect of Propofol and Dexamethasone on Reducing Fentanyl-Induced Cough, Journal of Isfahan Medical School (2018)
13. The Effects of Three Different Doses of Sufentanil on Changes in Blood Pressure and Heart Rate After Laryngoscopy and Intubation, and Comparison With the Control Group, Journal of Isfahan Medical School (2017)
14. Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Undergoing Tracheal Intubation for General Anesthesia, Journal of Research in Medical Sciences (2011)
15. The Effect of Ketamine and Dexamethasone on Frequency and Intensity of Fentanyl-Induced Cough, Journal of Isfahan Medical School (2018)
16. Comparing the Effects of Fentanyl and Sufentanil on Hemodynamic Parameters and Acute Pain Intensity After Deep Vitrectomy Surgery, Journal of Isfahan Medical School (2018)
17. Remifentanil-Ketamine Versus Fentanyl-Ketamine Sedation in Patients Undergoing Phacoemulsification With Topical Anesthesia: Comparison of Intraocular Pressure Changes and Sedation Quality, Journal of Research in Medical Sciences (2008)
18. Assessment of the Effects of Ketamine-Fentanyl Combination Versus Propofol-Remifentanil Combination for Sedation During Endoscopic Retrograde Cholangiopancreatography, Journal of Research in Medical Sciences (2014)
19. Sedation Quality of Low–Dose Ketamine Combined With Dexmedetomidine Versus Propofol in Phacoemulsification Under Local Anesthesia, Pakistan Journal of Ophthalmology (2023)
20. Comparing the Effect of Dexmedetomidine and Remifentanil on Hemodynamic Indices in Children Undergoing Endotracheal Intubation: A Randomized Clinical Trial, Journal of Mazandaran University of Medical Sciences (2019)
21. Comparison of the Effects of Morphine and Diltiazem on Blood Pressure and Heart Rate During Craniotomy Surgeries, Journal of Isfahan Medical School (2016)
22. The Effect of Intravenous Propofol or Pentazocine in Preventing Pruritus Due to Intrathecal Fentanyl in Lower Limb Surgery Compared With Control Group, Journal of Isfahan Medical School (2018)
23. Comparison Between the Effects of Propofol-Ketamine and Propofol-Fentanyl for Sedation in Cataract Surgery, Scientific Journal of Kurdistan University of Medical Sciences (2019)
24. The Comparability of Second Dose Thiopental With Lidocaine in the Attenuation of Cardiovascular Response to Endotracheal Intubation, Iranian Cardiovascular Research Journal (2009)
25. The Comparison of the Efficacy and Safety of Sedation With Etomidate- Fentanyl Versus Ketamine-Midazolam Combinations in Cataract Surgery, Journal of Isfahan Medical School (2012)
26. Evaluation of the Effect of Nasal Fentanyl in Comparison With Intravenous Fentanyl in Cataract Surgery by Phacoemulsification Method, Tehran University Medical Journal (2021)
27. Premedication With Oral Dextromethorphan Reduces Intra-Operative Morphine Requirement, Journal of Research in Medical Sciences (2005)
28. Investigating Sevoflurane, Remifentanil, and Propofol Effects on Recovery of Patients With Movement Disorders Under General Anesthesia, Journal of Advanced Pharmacy Education and Research (2024)
29. Comparison Study of Preemptive Effect of Intratechal Fentanyl With Intravenous Ondansetron, Dexamethasone, and Dexamethasone Plus Ondansetron on Shivering During Surgeries Under Spinal Anesthesia With Bupivacaine, Journal of Isfahan Medical School (2017)
30. Comparison of the Effects of Remifentanyl-Propofol and Remifentasnyl-Isoflurane on Hemodynamic Variables, Blood Gases, and Blood Glucose Among Patients Under General Anesthesia, Journal of Isfahan Medical School (2017)
31. Prophylactic Effects of Intravenous Dexamethasone and Lidocaine on Attenuating Hemodynamic-Respiratory and Pain Complications in Children Undergoing Cleft Palate Repair Surgery With General Anesthesia, Journal of Pain and Palliative Care Pharmacotherapy (2020)
32. Comparison of the Sedation Quality of Etomidate, Propofol, and Midazolam in Combination With Fentanyl During Phacoemulsification Cataract Surgery: A Double-Blind, Randomized, Controlled, Clinical Trial, Anesthesiology and Pain Medicine (2019)
33. Effect of Low-Dose Ketamine Versus Lidocaine on Hemodynamic Response to Endotracheal Intubation in General Anesthesia: A Prospective, Triple-Blinded, Randomized Controlled Trial, Tehran University Medical Journal (2023)
34. Comparing the Effects of Magnesium Sulfate and Nitroglycerin on the Control of Hypertension During and After Cataract Surgery Under Local Anesthesia and Intravenous Sedation, Journal of Isfahan Medical School (2016)
35. Effects of the Two Doses of Dexmedetomidine on Sedation, Agitation, and Bleeding During Pediatric Adenotonsillectomy, Anesthesiology and Pain Medicine (2021)
36. Comparison the Effects of Etomidate Infusion Versus Ketamine-Midazolam-Fentanyl Combination in Sedation for Cataract Surgery, Journal of Isfahan Medical School (2013)
37. Comparison of Dexmedetomidine Versus Midazolam on Hemodynamic Parameters, Bleeding, Satisfaction of Surgeons and Patients Who Underwent Laminectomy Surgery by Spinal Anesthesia, Tehran University Medical Journal (2021)
38. Comparison of the Efficacy of Midazolam and Dexmedetomidine in Quality of Sedation in Mechanically-Ventilated Patients Admitted to Intensive Care Unit, Journal of Isfahan Medical School (2018)
39. Preoperative Oral Dextromethorphan Vs. Clonidine to Prevent Tourniquet-Induced Cardiovascular Responses in Orthopaedic Patients Under General Anaesthesia, European Journal of Anaesthesiology (2007)
40. Comparative Study of Preemptive Ketorolac and Tetracaine Eye Drops on the Need for Sedatives and Analgesics During and After Cataract Surgery, Koomesh (2022)
41. Attenuation of the Pressor Response to Direct Laryngoscopy and Tracheal Intubation: Oral Clonidine Vs. Oral Gabapentin Premedication, Journal of Research in Medical Sciences (2011)
42. The Effect of Zolpidem or Promethazine Premedication on Agitation, Sedation and Cognitive Disorders Before and After Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2015)
43. A Comparative Study on the Prophylactic Effects of Ketamine, Dexamethasone, and Pethidine in Preventing Postoperative Shivering, Journal of Research in Medical Sciences (2012)
44. Premedication Propofol Dose to Prevent Emergency Delirium, Iranian Journal of Psychiatry (2022)
45. Effects of Lidocaine on Reducing the Need for Anesthetic Drugs During Ophthalmologic Surgeries, Journal of Isfahan Medical School (2013)
46. The Comparison of Spinal Anesthesia With General Anesthesia on the Postoperative Pain Scores and Analgesic Requirements After Elective Lower Abdominal Surgery: A Randomized, Double-Blinded Study, Journal of Research in Medical Sciences (2013)
47. Comparison of the Effect of Two Doses of Remifentanil Infusion on the Amount of Bleeding, Intraoperative Hemodynamic Changes and Complications After Rhinoplasty Surgery With General Anesthesia; [مقایسه تاثير انفوزیون دو دوز رميفنتانيل بر ميزان خونریزی، تغييرات همودیناميک حين عمل و عوارض پساز عمل جراحی رینوپلاستی پساز بيهوشی عمومی], Tehran University Medical Journal (2023)
48. Evaluation of the Efficacy of the Valsalva Maneuver and Fentanyl Administration for Attenuating Etomidate Injection Pain: A Double-Blind Clinical Trial, Journal of Emergency Practice and Trauma (2024)
49. Comparison of the Incidence and Severity of Delirium and Biochemical Factors After Coronary Artery Bypass Grafting With Dexmedetomidine: A Randomized Double-Blind Placebo-Controlled Clinical Trial Study, ARYA Atherosclerosis (2019)
50. Evaluating the Effect of Various Doses of Magnesium Sulfate on Cardiovascular Changing and Stimulating Due to Laryngoscopes and Intubation, Journal of Isfahan Medical School (2015)