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Prevalence and Antibiotic Susceptibility Patterns of Extended-Spectrum ß-Lactamase and Metallo-ß-Lactamase-Producing Uropathogenic Escherichia Coli Isolates Publisher Pubmed



Ghadiri H1 ; Vaez H2 ; Razaviazarkhiavi K3 ; Rezaee R3 ; Hajinoormohammadi M4 ; Rahimi AA5 ; Vaez V6 ; Kalantar E7
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, Faculty of Sciences, University of Tehran, Tehran, Iran
  2. 2. Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Microbiology, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
  5. 5. Department of Biology, Faculty of Sciences, Imam Hosein University, Tehran, Iran
  6. 6. Veterinary School, Islamic Azad University, Karaj, Iran
  7. 7. Department of Pathobiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Source: Laboratory Medicine Published:2014


Abstract

Healthcare professionals worldwide have expressed concern over infections by extended-spectrum ß-lactamase (ESBL) and metallo-ßlactamase (MBL)-producing bacteria. We evaluated the prevalence of ESBL-and MBL-producing Escherichia coli (E. coli) isolated from community-acquired urinary tract infections (UTIs) and their antibioticresistance profiles at 3 private laboratories in Tehran, Iran. E. coli isolates were mostly susceptible to meropenem (90.4%) and imipenem (90.0%), followed by amikacin (89.0%) and gentamicin (84.7%). Moreover, we detected that, of the E. coli isolates, 67 (22.3%) were ESBL producers and 21 (7.0%) of E. coli isolates were MBL positive via the imipenem-ethylenediaminetetraacetic acid (EDTA) combined disc test. This report is the first, to our knowledge, on the prevalence of MBL-producing uropathogenic E. coli (UPEC) strains in Iran. The antibiotic resistance of E. coli isolates revealed that 122 (40.7%) were multidrug resistant. The high number of antibiotic-resistant and ß-lactamase-producing UPEC strains necessitates further attention and consideration, particularly MBL-producing strains.
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