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Injection of Lidocaine Alone Versus Lidocaine Plus Dexmedetomidine in Impacted Third Molar Extraction Surgery, a Double-Blind Randomized Control Trial for Postoperative Pain Evaluation Publisher Pubmed



Alizargar J1 ; Etemadi Sh M2 ; Kaviani N3 ; Wu SFV4 ; Jafarzadeh K5 ; Ranjbarian P6 ; Hsieh NC7
Authors
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Authors Affiliations
  1. 1. Research Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, Taipei City, 112, Taiwan
  2. 2. Department of Oral and Maxillofacial Surgery, Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Oral and Maxillofacial Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. College of Nursing, School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City, 112, Taiwan
  5. 5. Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Endodontics, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
  7. 7. Department of Information Management, National Taipei University of Nursing and Health Sciences, Taipei City, 112, Taiwan

Source: Pain Research and Management Published:2021


Abstract

Objectives. Administration of medications such as dexmedetomidine as a topical anesthetic has been suggested in the pain control in dentistry. This double-blind randomized control trial study evaluated postoperative pain and associated factors following impacted third molar extraction surgery. Lidocaine alone was taken as the control and lidocaine plus dexmedetomidine as the intervention. Materials and Methods. Forty patients undergoing mandibular third molar extraction entered the study and were randomly allocated to the control and interventional groups. 0.15 ml of dexmedetomidine was added to each lidocaine cartridge and the drug concentration was adjusted to 15 μg for the intervention group while only lidocaine was used in the control group. A visual analog scale was used to measure and record pain levels at the end of the surgery and 6, 12, and 24 hours after the surgery and number of painkillers taken by the patients after the surgery was also recorded. Results. Pain scores of the intervention group decreased significantly during the surgery and also 6, 12, and 24 hours after the surgery compared to the control group. The pain score was correlated significantly with our intervention during the surgery and also 6 and 12 hours after that (all P value<0.05). There was a nonsignificant reduction in the number of painkillers taken by the patients at 6, 12, and 24 hours after surgery (all P value>0.05). Conclusion. In patients undergoing molar surgery, administration of a combination of dexmedetomidine and lidocaine is beneficial for the pain control. Clinical Relevance. Compared to the injection of lidocaine alone, combination of dexmedetomidine and lidocaine can be used for a better pain control in molar surgeries. © 2021 Javad Alizargar et al.
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