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Effect of Chlordiazepoxide and Oxazepam on the Success Rate of Mandibular Nerve Block Anesthesia: A Randomized Double Blind Control Trial



Nazari H1 ; Nazari H1 ; Sharifi R3 ; Daneshvar M4 ; Akbari A4
Authors
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Authors Affiliations
  1. 1. Department of Oral and Maxillofacial Surgery, School of Dentistry, Kermanshah University of Medial Sciences, Kermanshah, Iran
  2. 2. Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medial Sciences, Isfahan, Iran
  3. 3. Department of Endodontic, School of Dentistry, Kermanshah University of Medial Sciences, Kermanshah, Iran
  4. 4. Students Research Committee, School of Dentistry, Kermanshah University of Medial Sciences, Kermanshah, Iran

Source: Advances in Environmental Biology Published:2014

Abstract

Introduction: The success rate of inferior alveolar nerve block (IANB) has always been discussed. The present study was aimed to investigate the effect of chlordiazepoxide and oxazepam on the success rate of mandibular block anesthesia. Materials and Methods: In this randomized double blind clinical trial study, 75 healthy adults with no consumption of medications affecting pain perception were investigated. The participants were randomly assigned into three groups, 25 participants in each group. The patients in chlordiazepoxide and oxazepam groups received 10 mg chlordiazepoxide and 10 mg oxazepam orally two hours before the nerve block, respectively. The patients in control group received placebo. Then, the inferior alveolar nerve block was performed using a cartridge containing lidocaine 2% and epinephrine 1/80,000. The success rate of IANB in 5, 15 and 30-minute periods after performing the nerve block in the second premolar and first molar in reaction to the stimuli resulting from an electric pulp tester was considered as the block success, and the pain level during the needle insertion into the soft tissue was measured by a visual analoge scale (VAS). Data were analyzed by SPSS 16 software using ANOVA, chi-square and Fisher's exact tests. Results: The chlordiazepoxide and diazepam groups indicated a significantly higher success rate than the control group (P<0.05). However, there was no significant difference between chlordiazepoxide and diazepam groups in terms of the block success rate (P>0.05). The pain level during the needle insertion into the soft tissue was significantly lower in chlordiazepoxide and diazepam groups in comparison with control group (P<0.05). Moreover, no significant difference was observed between chlordiazepoxide and diazepam groups regarding the pain level during the needle insertion into the soft tissue (P>0.05). Conclusion: Oral administration of chlordiazepoxide and diazepam can significantly increase the success rate of inferior alveolar verve block for the first 15 minutes and can reduce the pain during needle insertion. © 2014 AENSI Publisher All rights reserved.
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