Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Prophylactic Aminophylline for Prevention of Apnea at Higher-Risk Preterm Neonates Publisher



Armanian AM1 ; Badiee Z1 ; Afghari R2 ; Salehimehr N3 ; Hassanzade A4 ; Sheikhzadeh S5 ; Tehrani MS5 ; Rezvan G5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Al-Mahdi University, Isfahan, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. NICU Ward, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Red Crescent Medical Journal Published:2014


Abstract

Background: A few studies have been carried on preventive drugs for apnea of preterm neonates. Objectives: This study aimed to assess the safety and prophylactic effects of aminophylline on the incidence of apnea in premature neonates. Patients and Methods: This study was a randomized clinical trial (RCT) research. The prophylactic effect of aminophylline on apnea was investigated in premature babies in our NICU (IRAN-Isfahan). In the study group (A), 5 mg/kg aminophylline was initially administered as a loading dose. Then, every 8 hours, 1.5 mg/kg was given as maintenance dose for the next 10 days. In the control group (C), no aminophylline was used during the first ten days of life. Results: Fifty-two neonates were randomized for the study and all of them completed it. Primary outcomes were clearly different between the two groups. Only 2 infants (7.7%) who had been placed in aminophylline group developed apnea, as compared to 16 infants (61.5%) in the control group (P < 0.001). Three and four neonates (11.5%, 15.4%) in the aminophylline group developed bradycardia and cyanosis respectively, as compared to 16 infants (61.5%) who did not receive aminophylline (P < 0.001). Median time of need to NCPAP (Nasal Continuous Positive Airway Pressure) was 1 (0-4) days and 2.5 (0.5-6.5) days in group A and C, respectively (P = 0.03). No side effects were reported in neonates (P > 0.999). Median time of hospitalization was shorter in aminophylline group (P = 0.04). Conclusions: This study supports the preventative effects of aminophylline on apnea in extreme premature infants. In other words, the more premature an infant, the greater the preventative effect of aminophylline on the incidence of apnea and bradycardia. © 2014, Iranian Red Crescent Medical Journal.
Related Docs
View other Related Docs
1. Caffeine Administration to Prevent Apnea in Very Premature Infants, Pediatrics and Neonatology (2016)
2. Reducing the Incidence of Chronic Lung Disease in Very Premature Infants With Aminophylline, International Journal of Preventive Medicine (2014)
3. Effect of Prophylactic Caffeine on Noninvasive Respiratory Support in Preterm Neonates Weighing 1250-2000 G: A Randomized Controlled Trial, Archives of Iranian Medicine (2022)
4. Comparison of Respiratory Complications of Propofol and Isoflurane Among Six-Months to Two-Years-Old Infants Undergoing Inguinal Herniorrhaphy Under General Anesthesia With Laryngeal Mask Airway, Journal of Isfahan Medical School (2017)
5. Effects of Positioning on Complications of Preterm Infants With Respiratory Distress Syndrome Treated With Nasal Continuous Positive Airway Pressure: A Randomized Clinical Trial, Iranian Journal of Neonatology (2023)
6. Nasal High-Frequency Oscillatory Ventilation (Nhfov) Versus Nasal Continuous Positive Airway Pressure (Ncpap) As an Initial Therapy for Respiratory Distress Syndrome (Rds) in Preterm and Near-Term Infants, BMJ Paediatrics Open (2019)
7. Effects of Aminophyllinein Preventing Renal Failure in Premature Neonates With Asphyxia in Isfahan-Iran., JPMA. The Journal of the Pakistan Medical Association (2012)
8. Low-Dose Intravenous Acetaminophen Versus Oral Ibuprofen for the Closure of Patent Ductus Arteriosus in Premature Neonates, Journal of Research in Medical Sciences (2019)
Experts (# of related papers)
View all Related Experts
Amir-Mohammad Armanian (9)
Zohreh Badiee (7)
Other Related Docs
9. A Comparison of the Effect of Nasal Bi‑Level Positive Airway Pressure and Sigh‑Positive Airway Pressure on the Treatment of the Preterm Newborns Weighing Less Than 1500 G Affiliated With Respiratory Distress Syndrome, International Journal of Preventive Medicine (2016)
10. Comparison of 25- Hydroxy Vitamin D Levels in Premature Infants With and Without Respiratory Distress, Iranian Journal of Neonatology (2020)
11. Protective Dressings, Injury, and Device Failure in Preterm Infants Receiving Nasal Continuous Positive Airway Pressure: A Randomized Controlled Trial, Advances in Skin and Wound Care (2021)
12. The Duration of Hospitalization and Readmission Rate of Low Birth Weight Infants in a Tertiary Referral Hospital in Isfahan, Iran, Iranian Journal of Neonatology (2015)
13. Early Administration of Surfactant Via a Thin Intratracheal Catheter in Preterm Infants With Respiratory Distress Syndrome: Feasibility and Outcome, Journal of Research in Pharmacy Practice (2015)
14. Evaluation of the Effects of Surfactant Replacement Therapy in Neonatal Respiratory Distress Syndrome, Chinese Journal of Contemporary Pediatrics (2009)
15. Sudden Complete Versus Gradual Weaning From Nasal Continuous Positive Airway Pressure in Preterm Neonates: A Randomized Controlled Trial, Iranian Journal of Neonatology (2019)
16. Intratracheal Administration of Budesonide-Instilled Surfactant for Prevention of Bronchopulmonary Dysplasia: A Randomized Controlled Clinical Trial, Iranian Journal of Neonatology (2023)
17. Heated Humidified High Flow Nasal Cannula (Hhhfnc) Is Not an Effective Method for Initial Treatment of Respiratory Distress Syndrome (Rds) Versus Nasal Intermittent Mandatory Ventilation (Nimv) and Nasal Continuous Positive Airway Pressure (Ncpap), Journal of Research in Medical Sciences (2019)
18. High Flow Nasal Cannula As a Method for Rapid Weaning From Nasal Continuous Positive Airway Pressure, International Journal of Preventive Medicine (2015)
19. Initial Treatment of Respiratory Distress Syndrome With Nasal Intermittent Mandatory Ventilation Versus Nasal Continuous Positive Airway Pressure: A Randomized Controlled Trial, International Journal of Preventive Medicine (2014)
20. Aromatherapy With Rosa Damascenes in Apnea, Bradycardia and Spo2 of Preterm Infants; a Randomized Clinical Trial, International Journal of Pediatrics (2016)
21. The Effect of Inhaled Budesonide on the Prevention of Chronic Lung Disease in Premature Neonates With Respiratory Distress Syndrome, International Journal of Preventive Medicine (2018)
22. High-Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome, Journal of Isfahan Medical School (2011)
23. Effects of the Time Interval Between Antenatal Corticosteroid Exposure and Delivery on Neonatal Outcome of Premature Infants, Journal of Isfahan Medical School (2013)
24. Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial, Indian Journal of Pediatrics (2015)
25. Risk Factors of Pneumothorax in Preterm Infants, Journal of Isfahan Medical School (2013)
26. Comparison of Epinephrine to Salbutamol in Acute Bronchiolitis, Iranian Journal of Pediatrics (2012)
27. Noninvasive Positive Pressure Ventilation or Conventional Mechanical Ventilation for Neonatal Continuous Positive Airway Pressure Failure, International Journal of Preventive Medicine (2014)