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Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial Publisher Pubmed



Modaresi MR1 ; Faghihinia J2 ; Kelishadi R2 ; Reisi M1 ; Mirlohi S1 ; Pajhang F3 ; Sadeghian M4
Authors
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Authors Affiliations
  1. 1. Department of Pediatric Pulmonology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pediatrics, Shariati Hospital of Isfahan, Isfahan, Iran
  4. 4. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran

Source: Indian Journal of Pediatrics Published:2015


Abstract

Objective: To assess the efficacy of nebulized magnesium sulfate as a bronchodilator in infants hospitalized with acute bronchiolitis. Methods: This three-center double masked randomized clinical trial comprised 120 children with moderate to severe bronchiolitis. They were randomly assigned into two groups: the first group was treated with nebulized magnesium sulfate (40 mg/kg) and nebulized epinephrine (0.1 ml/kg) and the second group (control) was treated with nebulized epinephrine (0.1 ml/kg). The primary outcome was the length of hospital stay. The use of oxygen, temperature, oxygen saturation (SPO 2 ), pulse rate (PR), respiratory rate (RR) and respiratory distress assessment instrument (RDAI) score were measured in the beginning of the study and during hospitalization. Results: The mean (SD) age of 120 infants was 5.1(±2.6) mo and 60% were boys. The length of hospital stay was not different between the two groups (P > 0.01). Use of oxygen supplementation, SPO 2 and vital signs were similar in the two groups. Improvement in RDAI score was significantly better in infants treated with nebulized magnesium sulfate than in the other group (P 0.01). Conclusions: Thus, in infants with acute bronchiolitis, the effect of nebulized magnesium sulfate is comparable to nebulized epinephrine. However nebulized magnesium sulfate can improve the clinical score so it may have additive effect to reduce symptoms during hospitalization. © 2015, Dr. K C Chaudhuri Foundation.
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