Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians

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Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians Publisher Pubmed

Javanmard SH¹ ; Keyhanian K¹ ; Loghmani P¹ ; Abbas Samety A¹ ; Haghdoost F² ; Rafiei L¹ ; Talaei M³ ; Asgari S^{3, 4} ; Jazi MH^{4, 5} ; Sarrafzadegan N^{3, 5}

Source: Molecular Biology Reports Published:2012

Abstract

Heme oxygenase-1 (HO-1) which is a ratelimiting enzyme in heme degradation processes shows a dinucleotide GT repeat in the promoter that alters the level of gene transcription. This study is aimed to assess the association of HO-1 gene promoter polymorphism and metabolic syndrome (MetS). A hundred and fifty two individuals, who were followed in Isfahan Cohort Study since 2001, were enrolled in this study. They consisted of 78 MetS patients and 74 controls without MetS. Blood samples were obtained from all participants and after extracting the genomic DNA, promoter sequence was determined by PCR-based genotyping. The serum levels of iron, ferritin and bilirubin were also measured in all subjects. The proportion of short and long allele frequency did not significantly differ in patients with metabolic syndrome compared to control group. In conclusion, the results showed that there is no significant difference between two groups in (GT)n repeat of HO-1 gene promoter. These findings suggest the insignificant role of genetic risk factors compared to environmental risk factors in the development of MetS.© Springer Science+Business Media B.V. 2011.

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Style	Citing Format
MLA	Javanmard SH, et al.. "Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians." Molecular Biology Reports, vol. 39, no. 3, 2012, pp. 3355-3360.
APA	Javanmard SH, Keyhanian K, Loghmani P, Abbas Samety A, Haghdoost F, Rafiei L, Talaei M, Asgari S, Jazi MH, Sarrafzadegan N (2012). Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians. Molecular Biology Reports, 39(3), 3355-3360.
Chicago	Javanmard SH, Keyhanian K, Loghmani P, Abbas Samety A, Haghdoost F, Rafiei L, Talaei M, Asgari S, Jazi MH, Sarrafzadegan N. "Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians." Molecular Biology Reports 39, no. 3 (2012): 3355-3360.
Harvard	Javanmard SH et al. (2012) 'Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians', Molecular Biology Reports, 39(3), pp. 3355-3360.
Vancouver	Javanmard SH, Keyhanian K, Loghmani P, Abbas Samety A, Haghdoost F, Rafiei L, et al.. Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians. Molecular Biology Reports. 2012;39(3):3355-3360.
BibTex	@article{ author = {Javanmard SH and Keyhanian K and Loghmani P and Abbas Samety A and Haghdoost F and Rafiei L and Talaei M and Asgari S and Jazi MH and Sarrafzadegan N}, title = {Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians}, journal = {Molecular Biology Reports}, volume = {39}, number = {3}, pages = {3355-3360}, year = {2012} }
RIS	TY - JOUR AU - Javanmard SH AU - Keyhanian K AU - Loghmani P AU - Abbas Samety A AU - Haghdoost F AU - Rafiei L AU - Talaei M AU - Asgari S AU - Jazi MH AU - Sarrafzadegan N TI - Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians JO - Molecular Biology Reports VL - 39 IS - 3 SP - 3355 EP - 3360 PY - 2012 ER -

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