Nanomedicine Enabled Prosthodontic Rehabilitation: Synergistic Roles of Dental Implants and Periodontal Surgery in Oral Tissue Engineering Publisher

Summary: Can nanomedicine reshape dental prosthetics? A review highlights regenerative potential, but safety, manufacturing and clinical consistency still need stronger evidence. #Dentistry #Nanomedicine

Jafari Z ; Tabatabaei H ; Damanpak N ; Jabbedari M H ; Namazikhah M ; Pourseyedi A ; Jobzari R G
Source: Nanomedicine Research Journal Published:2026

Abstract

Prosthodontic rehabilitation aims to restore oral function and aesthetics; however, long-term clinical success is often compromised by inadequate biomaterial integration, mechanical limitations of conventional prostheses, and the complex regenerative demands of oral tissues. Recent advances in nanomedicine and tissue engineering offer transformative strategies to overcome these challenges by enhancing biomaterial performance, promoting targeted therapeutic delivery, and facilitating biologically driven tissue regeneration. This review explores the synergistic integration of nanotechnology with dental implants and periodontal surgical strategies in the context of oral tissue engineering. Key developments in nano-engineered implant surfaces, bioactive and antibacterial coatings, nanostructured scaffolds, and controlled drug-delivery systems are discussed with emphasis on their roles in improving osseointegration, soft-tissue attachment, and periodontal regeneration. The review also highlights the incorporation of stem cells and growth-factor delivery through nanomaterials to mimic the native oral microenvironment and accelerate healing processes. In addition, current translational barriers including nanomaterial toxicity, manufacturing complexity, regulatory uncertainty, and variability in clinical outcomes are critically evaluated. By synthesizing recent biological, engineering, and clinical evidence, this review underscores the potential of nanomedicine-enabled prosthodontic rehabilitation to shift restorative dentistry toward precision-based, regenerative therapies. Continued interdisciplinary collaboration and standardized safety frameworks are essential to advance these technologies from experimental models to routine clinical practice and to realize their full potential in improving patient outcomes. © 2026 Tehran University of Medical Sciences. All rights reserved.