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Prevalence, Pattern, and Correlates of Polypharmacy Among Iranian Type Ii Diabetic Patients: Results From Pars Cohort Study Publisher Pubmed



Azadi M1, 2 ; Kamalipour A3 ; Vardanjani HM1, 4 ; Poustchi H5 ; Taherifard E6 ; Sharifi MH4 ; Salehi A1 ; Mohammadi Z7
Authors
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Authors Affiliations
  1. 1. MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Pediatrics Resident of Shahid Beheshti Hospital, Kashan University of Medical Sciences, Esfahan, Iran
  3. 3. Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego, CA, United States
  4. 4. Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Science, Tehran, Iran
  6. 6. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Science, Tehran, Iran

Source: Archives of Iranian Medicine Published:2021


Abstract

Background: Polypharmacy can negatively affect the life of type 2 diabetes (T2DM) patients. There is little evidence on the associated factors of, and patterns of polypharmacy among T2DM patients in developing regions. The aim of this study is to determine the population-based prevalence of polypharmacy, its associated factors, and pattern in southern Iran. Methods: We used baseline data from the Pars Cohort Study (PCS). Age-standardized prevalence of polypharmacy and its 95% confidence interval (CI) were estimated. Association of polypharmacy with demographic and socio-economic factors, anthropometric measures, serum biomarkers, physical activity, cigarette and tobacco smoking, and multimorbidity was assessed by applying multivariable Poisson modeling. Prevalence ratio (PR) and its CI were estimated. The Anatomical Therapeutic Chemical (ATC) classification system was used for drug classification. Results: Totally, 874 previously diagnosed T2DM patients with a mean age of 56.3±9.2 participated in the study. The estimated age-standardized prevalence for men and women was 17.2% (CI: 12.0-22.0) and 34.1% (CI: 33.2-39.4), respectively. The prevalence of hypertension, hyperlipidemia and cardiovascular disorders among the study population was 39%, 58% and 20%, respectively. Having more than four comorbidities (PR, 3.90; CI, 2.39-6.34), central obesity (PR, 2.66; CI, 1.03-6.84), and female gender (PR, 1.49; CI, 1.14-1.97) were associated with polypharmacy. Also, 56.0% of patients and 23.0% of elder patients (>59 years old) reported using anti-diabetic agents. Conclusion: Polypharmacy was low among T2DM patients. More than 75% of the elder population were not on anti-diabetic medications. Polypharmacy was higher among patients with multiple comorbidities, central obesity, lower physical activity, lower socio-economic status, younger age at diagnosis, and longer duration of T2DM. © 2021 Academy of Medical Sciences of I.R. Iran. All rights reserved.
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