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Multiple Sclerosis and Personality Traits: Associations With Depression and Anxiety Publisher Pubmed



Vaheb S1 ; Mokary Y2 ; Yazdan Panah M2 ; Shaygannejad A1 ; Afsharisafavi A3 ; Ghasemi M1, 4 ; Shaygannejad V1, 4 ; Moases Ghaffary E1 ; Mirmosayyeb O1
Authors
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Authors Affiliations
  1. 1. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Students Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
  3. 3. Department of Biostatistics and Epidemiology, Faculty of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
  4. 4. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: European Journal of Medical Research Published:2024


Abstract

Background: Depression and anxiety are commonly observed in people with multiple sclerosis (pwMS). There is a growing body of literature supporting the hypothesis that personality traits can influence the mood disorders. This study aimed to investigate the personality traits and their relationships with depression and anxiety among pwMS. Methods: 234 pwMS were involved in this cross-sectional study. Personality traits, depression, and anxiety were assessed using the NEO Five-Factor Inventory (NEO-FFI) and Hospital Anxiety and Depression Scale (HADS), respectively. Pearson's correlation coefficient and generalized linear model were employed to evaluate the relationships between demographic and clinical characteristics, NEO-FFI, and HADS subscales. Results: In pwMS, longer disease duration was significantly associated with lower level of conscientiousness (β = − 0.23, p = 0.008) and agreeableness (β = − 0.2, p = 0.01). Moreover, higher expanded disability status scale (EDSS) of pwMS had a significant relationship with higher level of neuroticism (β = 0.89, p = 0.01). Increased level of neuroticism was significantly correlated with lower level of extraversion (r = − 0.28, p < 0.001), openness (r = − 0.37, p < 0.001), agreeableness (r = − 0.31, p < 0.001), and conscientiousness (r = − 0.45, p < 0.001). PwMS with higher level of conscientiousness showed more extraversion (r = 0.23, p < 0.001), openness (r = 0.61, p < 0.001), and agreeableness (r = 0.41, p < 0.001). Elevated level of neuroticism was significantly associated with higher level of anxiety (β = 0.47, p < 0.001) and depression (β = 0.11, p < 0.001) among pwMS. Conclusion: The co-occurrence of depression and anxiety is probably associated with neuroticism among pwMS. Additionally, the impact of personality traits extends to influencing key disease aspects such as physical disability and disease duration in MS. © The Author(s) 2024.
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