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Evaluation of Pcl/Chitosan Electrospun Nanofibers for Liver Tissue Engineering Publisher



Semnani D1 ; Naghashzargar E1 ; Hadjianfar M1 ; Dehghan Manshadi F1 ; Mohammadi S2 ; Karbasi S3 ; Effaty F4
Authors
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Authors Affiliations
  1. 1. Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
  2. 2. National Cell Bank, Pasteur Institute of Iran, Tehran, Iran
  3. 3. School of Advance Technology in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Chemistry and Biotechnology, Concordia University, Montreal, Canada

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2017


Abstract

In this investigation, a nanofibrous scaffold was fabricated through electrospinning of polycaprolactone (PCL) and chitosan (CS) using a novel collector to make better orientation and pore size for cell infiltration. PCL/CS nanofibers with 90-rpm collector speed and 40° angle between collector wires of the new collector have fewer diameters with better pore, size and nanofibers orientation. Mechanical properties, roughness parameters, topology, structure, hydrophilicity, and cell growing were considered for liver tissue engineering. The cell culture was done using epithelial liver mouse cells. The developed electrospun PCL/CS scaffold using novel collector would be an excellent matrix for biomedical applications especially liver tissue engineering. © 2017, Copyright © Taylor & Francis Group, LLC.
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