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An in Vitro and in Vivo Study of Pcl/Chitosan Electrospun Mat on Polyurethane/Propolis Foam As a Bilayer Wound Dressing Publisher Pubmed



Shie Karizmeh M1 ; Poursamar SA1 ; Kefayat A2 ; Farahbakhsh Z3 ; Rafienia M4
Authors
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Authors Affiliations
  1. 1. Biomaterials, Nanotechnology, and Tissue Engineering Group, Advanced Medical Technology Department, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Department of Oncology, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  3. 3. Department of Biology, Nourdanesh Institute of Higher Education, Meymeh, Isfahan, Iran
  4. 4. Biosensor Research Center (BRC), Isfahan University of Medical Sciences (IUMS), Isfahan, Iran

Source: Biomaterials Advances Published:2022


Abstract

In the current study, we fabricated a bilayer wound dressing consisting of an electrospun poly-ε-caprolactone/chitosan (PCL/CS) fibrous mat as the sublayer and a polyurethane (PU) foam coated with ethanolic extract of propolis (EEP) as the top layer. By blending the solutions of PCL and CS, we fabricated an electrospun mat consisting of bead-free and uniform nanofibers with enhanced hydrophilicity, swelling ratio, and degradation properties. To further enhance the mechanical and antibacterial properties, we electrospun the PCL/CS solution on a PU foam coated with EEP to fabricate the PCL/CS-PU/EEP bilayer wound dressing. Furthermore, the PCL/CS-PU/EEP bilayer wound dressing demonstrated enhanced cell compatibility and healing properties through in vitro and in vivo studies. Therefore, the PCL/CS-PU/EEP bilayer wound dressing offers great potential to be used as a wound dressing because of its suitable mechanical properties, swelling profile, antibacterial activity, biocompatibility, and wound healing properties. © 2022 Elsevier B.V.
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