Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
The Efficacy of Home-Based Resistance Exercise and Game-Based Exercise Training on Microrna-21-5P Expression and Non-Alcoholic Fatty Liver Biomarkers in Children With Type 1 Diabetes Publisher



Mk Yasir Mohammed KAREEM ; V Minasian VAZGEN ; S Hovsepian SILVA ; M Hashemipour MAHIN
Authors

Source: Advanced Biomedical Research Published:2025


Abstract

Background: At present, increasing evidence has reported circulating microRNAs (miRNAs) as potential clinical biomarkers for specific diseases and administration of pharmaceutical agents. The main aim of this study was to compare the effect of two selected home-based resistance exercise (HBRE) and game-based exercise training (GBET) groups on microRNA21-5p expression and biomarkers related to non-alcoholic fatty liver in children with type 1 diabetes (T1D). Materials and Methods: Twenty children with T1D aged 10-15 years were randomly assigned to one of two groups (HBRE: n = 10; GBET: n = 10). The exercise training lasted for 8 weeks with three sessions per week. The liver enzyme profile, hemoglobin A1c (HbA1c), glucose, microRNA-21-5p, insulin, and Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) levels were measured before and after the interventions in both groups. In addition, the cardiopulmonary fitness and body fat percentage (BF%) of the participants were also evaluated. Results: After exercise interventions, miR-21-5p increased significantly for both intervention groups (HBRE: 8.9% vs. GBET: 6.7%; P = 0.001). The levels of alanine transaminase (ALT) (HBRE: 60.71% vs. GBET: 49.15%) and aspartate aminotransferase (AST) enzymes (HBRE: 54.02% vs. GBET: 34.02%), the glucose (HBRE: 15.03% vs. GBET: 16.26%), and the HbA1c (HBRE: -10.44% vs. GBET: -6.52%) were decreased significantly (P ≤ 0.05). The cardiorespiratory endurance of subjects increased (HBRE: 2.85% vs. GBET: 3.75%), but there were no differences between groups (P ≥ 0.05). Conclusions: Both HBRE and GBET protocols were effective to improve cardiorespiratory fitness, liver enzyme profile, glycemic control, and miR-21-5p changes that seem to be indicative of the pathological status of T1D children. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Effects of Two Different School-Based Training on Serum Mir15b Expression and Lipid Profile of Adolescents With Obesity, International Journal of Preventive Medicine (2022)
2. Changes in Liver Enzymes and Metabolic Profile in Adolescents With Fatty Liver Following Exercise Interventions, Pediatric Gastroenterology, Hepatology and Nutrition (2020)
3. Modulations of Obesity-Related Micrornas After Exercise Intervention: A Systematic Review and Bioinformatics Analysis, Molecular Biology Reports (2021)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (4)
Nafiseh Esmaeil (2)
Other Related Docs
4. Dysregulated Mir-103 and Mir-143 Expression in Peripheral Blood Mononuclear Cells From Induced Prediabetes and Type 2 Diabetes Rats, Gene (2015)
5. Pivotal Role of Microrna-33 in Metabolic Syndrome: A Systematic Review, ARYA Atherosclerosis (2013)
6. Association of Dietary Insulin Index and Dietary Insulin Load With Metabolic Health Status in Iranian Overweight and Obese Adolescents, Frontiers in Nutrition (2022)
7. Factors Associated With Insulin Resistance and Non-Alcoholic Fatty Liver Disease Among Youths, Atherosclerosis (2009)
8. Evaluation of Mir-103 Expression in Peripheral Blood Mononuclear Cells of Type 2 Diabetic and Prediabetic Rats, Journal of Isfahan Medical School (2014)
9. Can a Trial of Motivational Lifestyle Counseling Be Effective for Controlling Childhood Obesity and the Associated Cardiometabolic Risk Factors?, Pediatrics and Neonatology (2012)
10. Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on Tlr4, Nf-Κb and Irf3 Expression in Young Overweight and Obese Girls, Public Health Genomics (2020)
11. Evaluation of the Effects of Dietary Energy Density on Anthropometric and Glycemic Indices and Lipid Profile in Women With Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2012)
12. The Effect of Grapes/Grape Products on Glycemic Response: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2021)
13. Changes of Plasma Angiogenic Factors During Chronic Resistance Exercise in Type I Diabetic Rats, Pakistan Journal of Medical Sciences (2012)
14. Meta-Inflammatory State and Insulin Resistance Can Improve After 10 Weeks of Combined All-Extremity High-Intensity Interval Training in Sedentary Overweight/Obese Females: A Quasi-Experimental Study, Journal of Diabetes and Metabolic Disorders (2020)
15. Association of Triglyceride Glucose-Body Mass Index (Tyg-Bmi) With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis, PLOS ONE (2025)
16. Effect of Combination Exercise Training on Metabolic Syndrome Parameters in Postmenopausal Women With Breast Cancer, Journal of Cancer Research and Therapeutics (2012)
17. Chocolate Milk for Recovery From Exercise: A Systematic Review and Meta-Analysis of Controlled Clinical Trials, European Journal of Clinical Nutrition (2019)
18. Evaluating the Efficacy of Irisin Injection in Mimicking the Molecular Responses Induced by Endurance Exercise in Mouse Liver Tissue, International Journal of Preventive Medicine (2024)
19. Evaluation of Microrna Expression Pattern (Mir-28, Mir-181A, Mir-34A, and Mir-31) in Patients With Covid-19 Admitted to Icu and Diabetic Covid-19 Patients, Intervirology (2023)
20. Investigation of the Relationship Between Mir-33A, Mir-122, Erythrocyte Membrane Fatty Acids Profile, and Serum Lipids With Components of Metabolic Syndrome in Type 2 Diabetic Patients, Research in Pharmaceutical Sciences (2022)